Results 31 to 40 of about 511,041 (280)
Targeted mRNA demethylation in Arabidopsis using plant m6A editor
Plant Methods, 2023 Background N6-methyladenosine (m6A) is an important epigenetic modification involved in RNA stability and translation regulation. Manipulating the expression of RNA m6A methyltransferases or demethylases makes it difficult to study the effect of specific
Ruiqiu Fang +3 more
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Cell & Bioscience, 2022 RNA is spliced concomitantly with transcription and the process is organized by RNA splicing factors, transcriptional regulators, and chromatin regulators. RNA is spliced in close proximity to transcription machinery. Hence, some RNA splicing factors may
Koji Kitamura +6 more
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Characterization of RNA hairpin loop stability [PDF]
Nucleic Acids Research, 1988 Fifteen RNA hairpins that share the same stem sequence and have homopolymer loops of A, C and U residues which vary in length from three to nine nucleotides were synthesized and their thermal stabilities determined. Tm varies as a function of loop size but is almost independent of loop composition.
D R, Groebe, O C, Uhlenbeck
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Nuclear Noncoding RNAs and Genome Stability [PDF]
Molecular Cell, 2016 In modern molecular biology, RNA has emerged as a versatile macromolecule capable of mediating an astonishing number of biological functions beyond its role as a transient messenger of genetic information. The recent discovery and functional analyses of new classes of noncoding RNAs (ncRNAs) have revealed their widespread use in many pathways ...
Jasbeer S, Khanduja +4 more
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An evaluation of RNA-seq differential analysis methods.
PLoS ONE, 2022 RNA-seq is a high-throughput sequencing technology widely used for gene transcript discovery and quantification under different biological or biomedical conditions.
Dongmei Li +5 more
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Thermodynamic Features of Structural Motifs Formed by β-L-RNA. [PDF]
PLoS ONE, 2016 This is the first report to provide comprehensive thermodynamic and structural data concerning duplex, hairpin, quadruplex and i-motif structures in β-L-RNA series.
Marta Szabat +5 more
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Variations in the Abortive HIV-1 RNA Hairpin Do Not Impede Viral Sensing and Innate Immune Responses
Pathogens, 2021 The highly conserved trans-acting response element (TAR) present in the RNA genome of human immunodeficiency virus 1 (HIV-1) is a stably folded hairpin structure involved in viral replication.
Melissa Stunnenberg +4 more
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Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
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ALKBH5-mediated m6A demethylation of lncRNA PVT1 plays an oncogenic role in osteosarcoma
Cancer Cell International, 2020 Background Osteosarcoma (OS) is one of the most common malignant bone tumors. Plasmacytoma variant translocation 1 (PVT1) is a well-known oncogenic long noncoding RNA (lncRNA). However, to date, the regulatory mechanism of PVT1 upregulation in OS remains
Shuo Chen, Liwu Zhou, Yang Wang
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Retroviral strategy to stabilize viral RNA [PDF]
Current Opinion in Microbiology, 2014 Unspliced Rous sarcoma virus (RSV) retroviral mRNA undergoes nonsense-mediated RNA decay (NMD) if it has premature termination codons in the gag gene. However, its normal gag termination codon is not subject to NMD despite being 7kb from the 3' poly(A) sequence. An RNA stability element (RSE) has been identified immediately downstream of gag in the RSV
Bao Lin, Quek, Karen, Beemon
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