Results 121 to 130 of about 3,158,683 (345)

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

FEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source

Endogenous Bornavirus-like Elements in Bats: Evolutionary Insights from the Conserved Riboviral L-Gene in Microbats and Its Antisense Transcription in Myotis daubentonii

Viruses
Bats are ecologically diverse vertebrates characterized by their ability to host a wide range of viruses without apparent illness and the presence of numerous endogenous viral elements (EVEs).
Muriel Ritsch, Tom Eulenfeld, Kevin Lamkiewicz, Andreas Schoen, Friedemann Weber, Martin Hölzer, Manja Marz   +6 more
doaj   +1 more source

Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses

Nature Communications, 2016
Stimulator of interferon genes (STING) is known be involved in control of DNA viruses but has an unexplored role in control of RNA viruses. During infection with DNA viruses STING is activated downstream of cGAMP synthase (cGAS) to induce type I ...
C. Holm, Stine H. Rahbek, H. Gad, R. Bak, M. Jakobsen, Zhaozaho Jiang, A. L. Hansen, S. Jensen, Chenglong Sun, M. Thomsen, Anders Laustsen, Camilla G Nielsen, K. Severinsen, Yingluo Xiong, Dara L Burdette, V. Hornung, R. Lebbink, M. Duch, K. Fitzgerald, S. Bahrami, J. G. Mikkelsen, R. Hartmann, S. Paludan   +22 more
semanticscholar   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

HPV oncogenes expressed from only one of multiple integrated HPV DNA copies drive clonal cell expansion in cervical cancer

mBio
The integration of HPV DNA into human chromosomes plays a pivotal role in the onset of papillomavirus-related cancers. HPV DNA integration often occurs by linearizing the viral DNA in the E1/E2 region, resulting in the loss of a critical viral early ...
Lulu Yu, Vladimir Majerciak, Alexei Lobanov, Sameer Mirza, Vimla Band, Haibin Liu, Maggie Cam, Stephen H. Hughes, Douglas R. Lowy, Zhi-Ming Zheng   +9 more
doaj   +1 more source

THE BIOSYNTHESIS OF TOBACCO MOSAIC VIRUS RNA: RELATIONSHIPS TO THE BIOSYNTHESIS OF VIRUS-SPECIFIC RIBONUCLEASE-RESISTANT RNA [PDF]

, 1967
John C. Woolum, Georgia Shearer, Barry Commoner   +2 more
openalex   +1 more source

Fungal negative-stranded RNA virus that is related to bornaviruses and nyaviruses

Proceedings of the National Academy of Sciences of the United States of America, 2014
Significance Mycoviruses are viruses that infect fungi and replicate in fungi. Previously, no mycoviruses had been discovered with negative-stranded (−)ssRNA genomes.
Lijiang Liu, Jiatao Xie, Jiasen Cheng, Yanping Fu, Guoqing Li, Xianhong Yi, D. Jiāng   +6 more
semanticscholar   +1 more source

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, EarlyView.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source

Sanitary-Hygienic and Microbiological Monitoring over the Water Supply Sources and Surface Water Reservoirs during Natural Disaster in the Amur-River Territory

Проблемы особо опасных инфекций, 2014
Emergency situation in summer 2013 due to flooding of extensive areas of the Russian Amur-River territories (including residential areas with different level of development of public services and amenities, agricultural land, sites of cattle grazing and ...
S. V. Balakhonov, S. A. Kosilko, O. P. Kurganova, V. A. Yanovich, V. A. Ott, T. Yu. Nekhryuk, P. V. Kopylov, Yu. A. Garbuz, L. M. Mikhailov, A. K. Noskov, E. S. Kulikalova, N. G. Gefan, V. A. Vishnyakov, N. B. Breneva, G. B. Mukhturgin, A. V. Sevost’Yanova, A. P. Beloshitskaya, A. O. Kotova, E. B. Dobrynina   +18 more
doaj   +1 more source

ON THE BIOSYNTHESIS AND STRUCTURE OF DOUBLE-STRANDED RNA IN VACCINIA VIRUS-INFECTED CELLS [PDF]

, 1969
Peter Duesberg, Clarence Colby
openalex   +1 more source