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Why are RNA virus mutation rates so damn high?
PLoS Biology, 2018 The high mutation rate of RNA viruses is credited with their evolvability and virulence. This Primer, however, discusses recent evidence that this is, in part, a byproduct of selection for faster genomic replication.
S. Duffy
semanticscholar +1 more source
RNA virus interference via CRISPR/Cas13a system in plants
Genome Biology, 2017 CRISPR/Cas systems confer immunity against invading nucleic acids and phages in bacteria and archaea. CRISPR/Cas13a (known previously as C2c2) is a class 2 type VI-A ribonuclease capable of targeting and cleaving single-stranded RNA (ssRNA) molecules of ...
R. Aman +7 more
semanticscholar +1 more source
Correction to: Circular RNAs and RNase L in PKR activation and virus infection
Cell & Bioscience, 2019 In the publication of this article [1], there are a few errors in the article.
Zhi-Ming Zheng
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Role of Infectious Agents in the Etiology of Kawasaki Disease [PDF]
Pediatric Infectious Disease, 2022 Kawasaki disease (KD) is a multisystemic childhood vasculitis that predominantly affects the coronary arteries. The constellation of clinical features in KD, such as, acute onset of fever, redness of lips and oral mucosa, rash, swelling over palms and ...
Aaqib Banday +2 more
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Circular RNAs and RNase L in PKR activation and virus infection
Cell & Bioscience, 2019 Circular RNAs (circRNAs) from back-splicing have been found in every cell and tissue. By binding to miRNAs and proteins or even by encoding small proteins, circRNAs are now emerging as important regulators in modulating transcription, RNA splicing and ...
Zhi-Ming Zheng
doaj +1 more source
Establishing RNA virus resistance in plants by harnessing CRISPR immune system
Plant Biotechnology Journal, 2018 Summary Recently, CRISPR‐Cas (clustered, regularly interspaced short palindromic repeats–CRISPR‐associated proteins) system has been used to produce plants resistant to DNA virus infections.
Tong Zhang +6 more
semanticscholar +1 more source
CRISPR-Cas13d mediates robust RNA virus interference in plants
Genome Biology, 2019 CRISPR-Cas systems endow bacterial and archaeal species with adaptive immunity mechanisms to fend off invading phages and foreign genetic elements. CRISPR-Cas9 has been harnessed to confer virus interference against DNA viruses in eukaryotes, including ...
Ahmed Mahas, R. Aman, Magdy M. Mahfouz
semanticscholar +1 more source
Riboswitching on RNA virus replication [PDF]
Proceedings of the National Academy of Sciences, 2007 Positive-strand RNA viruses direct different virus-specific processes during their infection of host cells. Fundamental events such as viral RNA genome replication are controlled by viral regulatory RNA elements (REs). Here, we have investigated the possibility of specifically modulating the action of a viral RE using RNA aptamer technology.
K. Andrew White, Sheng Wang
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Lipids and RNA virus replication [PDF]
Current Opinion in Virology, 2014 Most viruses rely heavily on their host machinery to successfully replicate their genome and produce new virus particles. Recently, the interaction of positive-strand RNA viruses with the lipid biosynthetic and transport machinery has been the subject of intense investigation.
Lorena Sanchez-Felipe, Kouacou V. Konan
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RNA Virus Replication Complexes
PLoS Pathogens, 2010 The majority of viruses infecting animals and plants today are RNA viruses [1]. There are double-stranded (ds) RNA viruses with dsRNA genomes, as well as (+) and (−)RNA viruses whose genomes are single-stranded (ss) RNA of either positive or negative polarity. RNA viruses have small genomes that rarely exceed 30 kb in size, and a large portion of their
Qiaozhen Ye, Yizhi Jane Tao
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