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Self-Replicating RNA Viruses for RNA Therapeutics [PDF]

Molecules, 2018
Self-replicating single-stranded RNA viruses such as alphaviruses, flaviviruses, measles viruses, and rhabdoviruses provide efficient delivery and high-level expression of therapeutic genes due to their high capacity of RNA replication.
Kenneth Lundstrom
doaj   +3 more sources

RNA Structures and Their Role in Selective Genome Packaging

Viruses, 2021
To generate infectious viral particles, viruses must specifically select their genomic RNA from milieu that contains a complex mixture of cellular or non-genomic viral RNAs.
Liqing Ye, Uddhav B. Ambi, Marco Olguin-Nava, Anne-Sophie Gribling-Burrer, Shazeb Ahmad, Patrick Bohn, Melanie M. Weber, Redmond P. Smyth   +7 more
doaj   +1 more source

Interactions of the Insect-Specific Palm Creek Virus with Zika and Chikungunya Viruses in Aedes Mosquitoes

Microorganisms, 2021
Palm Creek virus (PCV) is an insect-specific flavivirus that can interfere with the replication of mosquito-borne flaviviruses in Culex mosquitoes, thereby potentially reducing disease transmission.
Cassandra Koh, Annabelle Henrion-Lacritick, Lionel Frangeul, Maria-Carla Saleh   +3 more
doaj   +1 more source

Hidden Viral Sequences in Public Sequencing Data and Warning for Future Emerging Diseases

mBio, 2021
RNA viruses cause numerous emerging diseases, mostly due to transmission from mammalian and avian reservoirs. Large-scale surveillance of RNA viral infections in these animals is a fundamental step for controlling viral infectious diseases.
Junna Kawasaki, Shohei Kojima, Keizo Tomonaga, Masayuki Horie   +3 more
doaj   +1 more source

Evidence For Long-Lasting Transgenerational Antiviral Immunity in Insects

Cell Reports, 2020
Summary: Transgenerational immune priming (TGIP) allows memory-like immune responses to be transmitted from parents to offspring in many invertebrates.
Juan A. Mondotte, Valérie Gausson, Lionel Frangeul, Yasutsugu Suzuki, Marie Vazeille, Vanesa Mongelli, Hervé Blanc, Anna-Bella Failloux, Maria-Carla Saleh   +8 more
doaj   +1 more source

The Railmap of Type I Interferon Induction: Subcellular Network Plan and How Viruses Can Change Tracks

Cells, 2022
The innate immune response constitutes the cell’s first line of defense against viruses and culminates in the expression of type I interferon (IFN) and IFN-stimulated genes, inducing an antiviral state in infected and neighboring cells.
Laura Weber, Gabrielle Vieyres
doaj   +1 more source

Vaccines against RNA Viruses [PDF]

Vaccines, 2020
RNA viruses cause animal, human, and zoonotic diseases that affect millions of individuals, as is being exemplified by the devastating ongoing epidemic of the recently identified SARS-Cov-2 [...]
openaire   +4 more sources

Reverse Genetics and Artificial Replication Systems of Borna Disease Virus 1

Viruses, 2022
Borna disease virus 1 (BoDV-1) is a neurotropic RNA virus belonging to the family Bornaviridae within the order Mononegavirales. Whereas BoDV-1 causes neurological and behavioral disorders, called Borna disease (BD), in a wide range of mammals, its ...
Takehiro Kanda, Keizo Tomonaga
doaj   +1 more source

Intranasal murine pneumonia virus-vectored SARS-CoV-2 vaccine induces mucosal and serum antibodies in macaques

iScience, 2023
Summary: Next-generation SARS-CoV-2 vaccines are needed that induce systemic and mucosal immunity. Murine pneumonia virus (MPV), a murine homolog of respiratory syncytial virus, is attenuated by host-range restriction in nonhuman primates and has a ...
Jaclyn A. Kaiser, Xueqiao Liu, Cindy Luongo, Yumiko Matsuoka, Celia Santos, Lijuan Yang, Richard Herbert, Ashley Castens, David W. Dorward, Reed F. Johnson, Hong-Su Park, Sharmin Afroz, Shirin Munir, Cyril Le Nouën, Ursula J. Buchholz   +14 more
doaj   +1 more source

Differential Small RNA Responses against Co-Infecting Insect-Specific Viruses in Aedes albopictus Mosquitoes

Viruses, 2020
The mosquito antiviral response has mainly been studied in the context of arthropod-borne virus (arbovirus) infection in female mosquitoes. However, in nature, both female and male mosquitoes are frequently infected with insect-specific viruses (ISVs ...
Lionel Frangeul, Hervé Blanc, Maria-Carla Saleh, Yasutsugu Suzuki   +3 more
doaj   +1 more source