Results 1 to 10 of about 3,202,245 (403)

Self-Replicating RNA Viruses for RNA Therapeutics [PDF]

Molecules, 2018
Self-replicating single-stranded RNA viruses such as alphaviruses, flaviviruses, measles viruses, and rhabdoviruses provide efficient delivery and high-level expression of therapeutic genes due to their high capacity of RNA replication.
Kenneth Lundstrom
doaj   +4 more sources

VirSorter2: a multi-classifier, expert-guided approach to detect diverse DNA and RNA viruses

Microbiome, 2021
Viruses are a significant player in many biosphere and human ecosystems, but most signals remain “hidden” in metagenomic/metatranscriptomic sequence datasets due to the lack of universal gene markers, database representatives, and insufficiently advanced
Jiarong Guo, B. Bolduc, A. Zayed, A. Varsani, Guillermo Domínguez-Huerta, Tom O. Delmont, Akbar Adjie Pratama, M. C. Gazitúa, D. Vik, M. Sullivan, S. Roux   +10 more
semanticscholar   +1 more source

RNA Structures and Their Role in Selective Genome Packaging

Viruses, 2021
To generate infectious viral particles, viruses must specifically select their genomic RNA from milieu that contains a complex mixture of cellular or non-genomic viral RNAs.
Liqing Ye, Uddhav B. Ambi, Marco Olguin-Nava, Anne-Sophie Gribling-Burrer, Shazeb Ahmad, Patrick Bohn, Melanie M. Weber, Redmond P. Smyth   +7 more
doaj   +1 more source

Hybrids of RNA viruses and viroid-like elements replicate in fungi

Nature Communications, 2023
Earth’s life may have originated as self-replicating RNA, and it has been argued that RNA viruses and viroid-like elements are remnants of such pre-cellular RNA world. RNA viruses are defined by linear RNA genomes encoding an RNA-dependent RNA polymerase
M. Forgia, B. Navarro, Stefania Daghino, Amelia Cervera, A. Gisel, S. Perotto, D. Aghayeva, M. Akinyuwa, E. Gobbi, I. Zheludev, Robert C. Edgar, R. Chikhi, M. Turina, A. Babaian, F. di Serio, M. de la Peña   +15 more
semanticscholar   +1 more source

Interactions of the Insect-Specific Palm Creek Virus with Zika and Chikungunya Viruses in Aedes Mosquitoes

Microorganisms, 2021
Palm Creek virus (PCV) is an insect-specific flavivirus that can interfere with the replication of mosquito-borne flaviviruses in Culex mosquitoes, thereby potentially reducing disease transmission.
Cassandra Koh, Annabelle Henrion-Lacritick, Lionel Frangeul, Maria-Carla Saleh   +3 more
doaj   +1 more source

Diversity and ecological footprint of Global Ocean RNA viruses

Science, 2022
DNA viruses are increasingly recognized as influencing marine microbes and microbe-mediated biogeochemical cycling. However, little is known about global marine RNA virus diversity, ecology, and ecosystem roles.
Guillermo Domínguez-Huerta, A. Zayed, J. Wainaina, Jiarong Guo, F. Tian, Akbar Adjie Pratama, B. Bolduc, Mohamed Mohssen, Olivier Zablocki, É. Pelletier, E. Delage, A. Alberti, J. Aury, Q. Carradec, C. da Silva, K. Labadie, J. Poulain, C. Bowler, D. Eveillard, L. Guidi, E. Karsenti, J. Kuhn, H. Ogata, P. Wincker, Alexander I. Culley, Samuel Chaffron, M. Sullivan   +26 more
semanticscholar   +1 more source

An isoform of Dicer protects mammalian stem cells against multiple RNA viruses

Science, 2021
An antiviral Dicer defends stem cells Stem cells have a pivotal role in maintaining tissue architecture, integrity, and renewal. Poirier et al.
Enzo Z. Poirier, M. D. Buck, P. Chakravarty, J. Carvalho, Bruno Frederico, A. Cardoso, L. Healy, Rachel Ulferts, R. Beale, C. Reis e Sousa   +9 more
semanticscholar   +1 more source

Structural insights into RNA polymerases of negative-sense RNA viruses

Nature Reviews Microbiology, 2021
RNA viruses include many important human and animal pathogens, such as the influenza viruses, respiratory syncytial virus, Ebola virus, measles virus and rabies virus.
A. J. T. te Velthuis, J. Grimes, E. Fodor   +2 more
semanticscholar   +1 more source

Cryptic and abundant marine viruses at the evolutionary origins of Earth’s RNA virome

Science, 2022
Whereas DNA viruses are known to be abundant, diverse, and commonly key ecosystem players, RNA viruses are insufficiently studied outside disease settings. In this study, we analyzed ≈28 terabases of Global Ocean RNA sequences to expand Earth’s RNA virus
A. Zayed, J. Wainaina, Guillermo Domínguez-Huerta, É. Pelletier, Jiarong Guo, Mohamed Mohssen, F. Tian, Akbar Adjie Pratama, B. Bolduc, Olivier Zablocki, Dylan Cronin, L. Solden, E. Delage, A. Alberti, J. Aury, Q. Carradec, C. da Silva, K. Labadie, J. Poulain, H. Ruscheweyh, Guillem Salazar, E. Shatoff, R. Bundschuh, K. Fredrick, L. Kubatko, Samuel Chaffron, Alexander I. Culley, S. Sunagawa, J. Kuhn, P. Wincker, M. Sullivan, S. Acinas, M. Babin, P. Bork, E. Boss, C. Bowler, G. Cochrane, C. de Vargas, G. Gorsky, L. Guidi, N. Grimsley, P. Hingamp, D. Iudicone, O. Jaillon, S. Kandels, L. Karp‐Boss, E. Karsenti, F. Not, H. Ogata, N. Poulton, S. Pesant, C. Sardet, S. Speich, L. Stemmann, M. Sullivan, Shinichi Sungawa, P. Wincker   +56 more
semanticscholar   +1 more source

Moisture modulates soil reservoirs of active DNA and RNA viruses

Communications Biology, 2021
Soil is known to harbor viruses, but the majority are uncharacterized and their responses to environmental changes are unknown. Here, we used a multi-omics approach (metagenomics, metatranscriptomics and metaproteomics) to detect active DNA viruses and ...
Ruonan Wu, M. Davison, Yuqian Gao, C. Nicora, J. Mcdermott, Kristin E. Burnum-Johnson, K. Hofmockel, J. Jansson   +7 more
semanticscholar   +1 more source