Results 101 to 110 of about 2,879,139 (364)

Are RNA Viruses Candidate Agents for the Next Global Pandemic? A Review

ILAR journal, 2017
Pathogenic RNA viruses are potentially the most important group involved in zoonotic disease transmission, and they represent a challenge for global disease control.
R. Carrasco‐Hernández, R. Jácome, Y. López Vidal, S. Ponce de León   +3 more
semanticscholar   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Multimodal SARS-CoV-2 interactome sketches the virus-host spatial organization

Communications Biology
An accurate spatial representation of protein-protein interaction networks is needed to achieve a realistic and biologically relevant representation of interactomes.
Guillaume Dugied, Estelle MN Laurent, Mikaël Attia, Jean-Pascal Gimeno, Kamel Bachiri, Payman Samavarchi-Tehrani, Flora Donati, Yannis Rahou, Sandie Munier, Faustine Amara, Mélanie Dos Santos, Nicolas Soler, Stevenn Volant, Natalia Pietrosemoli, Anne-Claude Gingras, Georgios A. Pavlopoulos, Sylvie van der Werf, Pascal Falter-Braun, Patrick Aloy, Yves Jacob, Anastassia Komarova, Yorgos Sofianatos, Etienne Coyaud, Caroline Demeret   +23 more
doaj   +1 more source

Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses

Nature Communications, 2016
Stimulator of interferon genes (STING) is known be involved in control of DNA viruses but has an unexplored role in control of RNA viruses. During infection with DNA viruses STING is activated downstream of cGAMP synthase (cGAS) to induce type I ...
C. Holm, Stine H. Rahbek, H. Gad, R. Bak, M. Jakobsen, Zhaozaho Jiang, A. L. Hansen, S. Jensen, Chenglong Sun, M. Thomsen, Anders Laustsen, Camilla G Nielsen, K. Severinsen, Yingluo Xiong, Dara L Burdette, V. Hornung, R. Lebbink, M. Duch, K. Fitzgerald, S. Bahrami, J. G. Mikkelsen, R. Hartmann, S. Paludan   +22 more
semanticscholar   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome

Nature Communications
The current model is that the influenza virus polymerase (FluPol) binds either to host RNA polymerase II (RNAP II) or to the acidic nuclear phosphoprotein 32 (ANP32), which drives its conformation and activity towards transcription or replication of the ...
Tim Krischuns, Benoît Arragain, Catherine Isel, Sylvain Paisant, Matthias Budt, Thorsten Wolff, Stephen Cusack, Nadia Naffakh   +7 more
doaj   +1 more source

Nasopharyngeal and serological anti SARS-CoV-2 IgG/IgA responses in COVID-19 patients

Journal of Clinical Virology Plus, 2021
Background: The systemic antibody responses to SARS-CoV-2 in COVID-19 patients has been extensively studied. However, less is known about the mucosal responses in the upper airways, the site of initial SARS-CoV-2 replication.
Bernadette Crescenzo-Chaigne, Sylvie Behillil, Vincent Enouf, Nicolas Escriou, Stephane Petres, Marie Noelle Ungeheuer, Jade Ghosn, Sarah Tubiana, Lila Bouadma, Sylvie van der Werf, Caroline Demeret   +10 more
doaj  

Epidemiological characteristics of human-infective RNA viruses

Scientific Data, 2017
RNA viruses are a major threat to human health. Here, based on extensive literature searches carried out over a period of 18 years, we provide a catalogue of all 214 known human-infective RNA virus species.
M. Woolhouse, Liam Brierley
semanticscholar   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Introduction to DNA Viruses

, 2017
RNA viruses replicate their genomes using virally encoded RNA-dependent RNA polymerase (RdRp). The RNA genome is the template for synthesis of additional RNA strands. During replication of RNA viruses, there are at least three types of RNA that must be synthesized: the genome, a copy of the genome (copy genome), and mRNAs.
openaire   +2 more sources