Results 131 to 140 of about 3,202,245 (403)

Persistent hepatitis C virus infection in vitro: coevolution of virus and host. [PDF]

, 2006
The virological and cellular consequences of persistent hepatitis C virus (HCV) infection have been elusive due to the absence of the requisite experimental systems.
Cheng, Guofeng, Chisari, Francis V, Chung, Josan, Gastaminza, Pablo, Isogawa, Masanori, McKeating, Jane A, Stamataki, Zania, Zhong, Jin   +7 more
core   +3 more sources

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Seasonal Genetic Drift of Human Influenza A Virus Quasispecies Revealed by Deep Sequencing

Frontiers in Microbiology, 2018
After a pandemic wave in 2009 following their introduction in the human population, the H1N1pdm09 viruses replaced the previously circulating, pre-pandemic H1N1 virus and, along with H3N2 viruses, are now responsible for the seasonal influenza type A ...
Cyril Barbezange, Cyril Barbezange, Cyril Barbezange, Cyril Barbezange, Louis Jones, Louis Jones, Louis Jones, Louis Jones, Hervé Blanc, Hervé Blanc, Ofer Isakov, Gershon Celniker, Vincent Enouf, Vincent Enouf, Vincent Enouf, Noam Shomron, Marco Vignuzzi, Marco Vignuzzi, Sylvie van der Werf, Sylvie van der Werf, Sylvie van der Werf   +20 more
doaj   +1 more source

Pathogenic Mechanism of a Highly Virulent Infectious Hematopoietic Necrosis Virus in Head Kidney of Rainbow Trout (Oncorhynchus mykiss) Analyzed by RNA-Seq Transcriptome Profiling [PDF]

, 2022
Jin-Woo Kim, Miyoung Cho, Jong-Won Lim, Hyeseong Choi, Suhee Hong   +4 more
openalex   +1 more source

Epidemiological characteristics of human-infective RNA viruses

Scientific Data, 2017
RNA viruses are a major threat to human health. Here, based on extensive literature searches carried out over a period of 18 years, we provide a catalogue of all 214 known human-infective RNA virus species.
M. Woolhouse, Liam Brierley
semanticscholar   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Attenuation of RNA viruses by redirecting their evolution in sequence space

Nature Microbiology, 2017
RNA viruses pose serious threats to human health. Their success relies on their capacity to generate genetic variability and, consequently, on their adaptive potential.
G. Moratorio, Rasmus Henningsson, C. Barbezange, Lucía Carrau, A. V. Bordería, H. Blanc, S. Beaucourt, Enzo Z. Poirier, T. Vallet, J. Boussier, Bryan C. Mounce, Magnus Fontes, M. Vignuzzi   +12 more
semanticscholar   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Multimodal SARS-CoV-2 interactome sketches the virus-host spatial organization

Communications Biology
An accurate spatial representation of protein-protein interaction networks is needed to achieve a realistic and biologically relevant representation of interactomes.
Guillaume Dugied, Estelle MN Laurent, Mikaël Attia, Jean-Pascal Gimeno, Kamel Bachiri, Payman Samavarchi-Tehrani, Flora Donati, Yannis Rahou, Sandie Munier, Faustine Amara, Mélanie Dos Santos, Nicolas Soler, Stevenn Volant, Natalia Pietrosemoli, Anne-Claude Gingras, Georgios A. Pavlopoulos, Sylvie van der Werf, Pascal Falter-Braun, Patrick Aloy, Yves Jacob, Anastassia Komarova, Yorgos Sofianatos, Etienne Coyaud, Caroline Demeret   +23 more
doaj   +1 more source

The Zika outbreak of the 21st century. [PDF]

, 2016
The Zika virus outbreak has captivated the attention of the global audience and information has spread rapidly and wildly through the internet and other media channels.
Ansari, Aftab, Chang, Christopher, Gershwin, M Eric, Ortiz, Kristina   +3 more
core   +1 more source