Results 91 to 100 of about 836,536 (329)
Rapid bedside inactivation of Ebola virus for safe nucleic acid tests [PDF]
, 2016 Rapid bedside inactivation of Ebola virus would be a solution for the safety of medical and technical staff, risk containment, sample transport and high-throughput or rapid diagnostic testing during an outbreak.
Bragstad, Karoline +9 more
core +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Chiral polymerisation and the RNA world [PDF]
, 2005 The purpose of this paper is to review two mathematical models: one for the formation of homochiral polymers from an originally chirally symmetric system; and the other, to show how, in an RNA-world scenario, RNA can simultaneously act both as ...
Coveney, Peter V., Wattis, Jonathan A.D.
core
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
The RNA World: Piecing together the historical development of a hypothesis
Mètode Science Studies Journal: Annual Review, 2016 The concept of an RNA world is a hypothesis firmly rooted in empirical data and is part of a long and complex scientific perspective that goes back more than fifty years to the discovery of the central role RNA and ribonucleotides play in protein ...
Antonio Lazcano
doaj +1 more source
Co-operation between Polymerases and Nucleotide Synthetases in the RNA World. [PDF]
PLoS Computational Biology, 2016 It is believed that life passed through an RNA World stage in which replication was sustained by catalytic RNAs (ribozymes). The two most obvious types of ribozymes are a polymerase, which uses a neighbouring strand as a template to make a complementary ...
Ye Eun Kim, Paul G Higgs
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Origins of Life, RNA world or alternative RNA world
Cell & Developmental Biology, 2012 Why and how our living-bodies, such as human beings, have originated from a barely non-life planet into the highly-intelligent life existing Earth, and have been interested and pursued by large population of readers and investigators. Based on evolution of Darwin’s arguments, some detailed evolutionary theories and steps have been renewed and discussed
Da Yong Lu, Ting Ren Lu
openaire +1 more source
Re-creating the RNA world [PDF]
Current Biology, 1995 Results from in vitro selection experiments can be used to construct and test models for the evolution of the RNA world. Surprisingly, the success of selected RNAs at binding ligands and catalyzing reactions may make it difficult to determine precisely the lineage of molecular fossils, molecules that are believed to have survived from the RNA world to ...
Hirao, Ichiro, Ellington, Andrew D.
openaire +2 more sources
NBLDA: Negative Binomial Linear Discriminant Analysis for RNA-Seq Data
, 2015 RNA-sequencing (RNA-Seq) has become a powerful technology to characterize gene expression profiles because it is more accurate and comprehensive than microarrays. Although statistical methods that have been developed for microarray data can be applied to
Dong, Kai +3 more
core +1 more source