Results 101 to 110 of about 291,851 (290)

Origin & influence of autocatalytic reaction networks at the advent of the RNA world

RNA Biology
Research on the origin of life investigates the transition from abiotic chemistry to the emergence of biology, with the ‘RNA world hypothesis’ as the leading theory. RNA’s dual role in storage and catalysis suggests its importance in this narrative.
Stephen A. Zorc, Raktim N. Roy
doaj   +1 more source

Watson-Crick pairing, the Heisenberg group and Milnor invariants

, 2008
We study the secondary structure of RNA determined by Watson-Crick pairing without pseudo-knots using Milnor invariants of links. We focus on the first non-trivial invariant, which we call the Heisenberg invariant.
Gadgil, Siddhartha
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

On the origin of life in the Zinc world. 2. Validation of the hypothesis on the photosynthesizing zinc sulfide edifices as cradles of life on Earth

Biology Direct, 2009
Background The accompanying article (A.Y. Mulkidjanian, Biology Direct 4:26) puts forward a detailed hypothesis on the role of zinc sulfide (ZnS) in the origin of life on Earth.
Mulkidjanian Armen Y, Galperin Michael Y
doaj   +1 more source

Artificial and Natural Genetic Information Processing [PDF]

, 2017
Conventional methods of genetic engineering and more recent genome editing techniques focus on identifying genetic target sequences for manipulation.
Witzany, Guenther
core  

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

RNA Back and Forth: Looking through Ribozyme and Viroid Motifs

Viruses, 2019
Current cellular facts allow us to follow the link from chemical to biochemical metabolites, from the ancient to the modern world. In this context, the “RNA world„ hypothesis proposes that early in the evolution of life, the ribozyme was ...
Marie-Christine Maurel, Fabrice Leclerc, Jacques Vergne, Giuseppe Zaccai   +3 more
doaj   +1 more source

Red Queen Coevolution on Fitness Landscapes

, 2013
Species do not merely evolve, they also coevolve with other organisms. Coevolution is a major force driving interacting species to continuously evolve ex- ploring their fitness landscapes. Coevolution involves the coupling of species fit- ness landscapes,
A. Hastings, A. Hoffman, A. Ilachinsky, A. Kerr, A.A. Berryman, A.F. Agrawal, A.F. Agrawal, B. Drossel, C. Darwin, C.M. Lively, D.J. Mode, D.K. Clarke, D.M. Raup, D.M. Raup, E. Decaestecker, F. Dercole, F. Jacob, F. Jacob, G. Lafforgue, G. Nicolis, H. Freund, H. Haken, H.H. Flor, J. Jaenike, J. Quer, J. Sardanyés, J. Sardanyés, J. Sardanyés, J. Sardanyés, J. Sardanyés, J. Sardanyés, J. Sardanyés, J. Seger, J.A.G.M. Visser de, J.B.S. Haldane, J.M. Montoya, J.N. Thompson, J.N. Thompson, J.N. Thompson, J.N. Thompson, J.S. McCaskill, J.S. Weltz, K. Kaneko, K.C. King, K.Y. Yip, L. Valen Van, L. Valen Van, L. Valen Van, L.T. Morran, M. Eigen, M. Pascual, M. Tegmark, M.A. Parker, M.E.J. Newman, M.J. Benton, N.C. Stenseth, P. Bak, P.D. Roopnarine, P.R. Ehrlich, R. Ferrière, R.K. Grosberg, R.M. May, R.S. Howard, R.V. Solé, R.V. Solé, R.V. Solé, R.V. Solé, R.V. Solé, R.V. Solé, R.V. Solé, R.V. Solé, R.V. Solé, R.V. Solé, R.V. Solé, S. Wright, S. Wright, S.A. Kauffman, S.A. Kauffman, S.C. Manrubia, S.F. Elena, S.J. Gould, T. Dobzhansky, T. Ikegami, T.J. Case, U. Dieckmann, W.D. Hamilton, W.D. Hamilton, W.H. Li, Z.Q. Chen   +88 more
core   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Evolvability tradeoffs in emergent digital replicators

, 2016
The role of historical contingency in the origin of life is one of the great unknowns in modern science. Only one example of life exists--one that proceeded from a single self-replicating organism (or a set of replicating hyper-cycles) to the vast ...
Adami, Christoph, Hintze, Arend, LaBar, Thomas   +2 more
core   +1 more source