Results 121 to 130 of about 298 (200)

Characteristics and Outcomes of Male Participants in a Multicenter Longitudinal Australian Study Cohort

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to determine the differences in demographic, serologic, and clinical characteristics between male and female patients with systemic sclerosis (SSc) in an Australian cohort. Methods This was a retrospective observational study using data from the Australian Scleroderma Cohort Study.
Emily Lin, Dylan Hansen, Laura Ross, Gene‐Siew Ngian, Susanna Proudman, Gabor Major, Maryam Tabesh, Mandana Nikpour, Jennifer Walker, Lauren Host, Nava Ferdowsi, Alannah Quinlivan, Wendy Stevens, Joanne Sahhar, Diane Apostolopoulos   +14 more
wiley   +1 more source

Editorial: Insights in RNA: 2025

Frontiers in Genetics
Hassan Dastsooz, Naoyuki Kataoka, Nicoletta Potenza   +2 more
doaj   +1 more source

Abiotic Co-Production of RNA and DNA in Model Protocells: Challenging the RNA World Hypothesis with Meisner et al.'s Methodology

The RNA World Hypothesis (RWH) posits that RNA, with its genetic and catalytic capabilities, was the primordial self-replicating molecule, with DNA emerging as an RNA-derived product. Meisner et al. (2019) [1] supported RWH by demonstrating nonenzymatic RNA synthesis in model protocells, achieving ribonucleotide yields of ~2–5% under prebiotic ...
openaire   +1 more source

Immunosuppressive Drug Use in Limited Systemic Sclerosis: An International Survey

Arthritis Care &Research, EarlyView.
Objective Current guidelines recommend immunosuppressive treatment for diffuse cutaneous systemic sclerosis but are less clear on their use in limited cutaneous systemic sclerosis (lcSSc) in the absence of internal organ complications. We conducted an international survey to understand current immunosuppressive drug prescribing patterns in lcSSc ...
Sabrina Hoa, Yicheng Mu, Marie Hudson, Janet Pope   +3 more
wiley   +1 more source

Coupled Molecular Dynamics and Kinetic Modeling of RNA Replication Refute RNA World Hypothesis, Supporting Synergistic Matter World Model(Estimated Calculation Simulation)

The RNA World Hypothesis (RWH) posits that RNA alone initiated life, serving as both genetic material and catalyst. However, RNA’s chemical instability, poor catalytic efficiency, and high mutation rates challenge its evolvability. The Matter World Hypothesis (MWH) proposes that life emerged from synergistic interactions among RNA, DNA, peptides ...
openaire   +1 more source

Microsecond-to-Millisecond Simulations and Kinetic Modeling Refute RNA World Hypothesis, Supporting Synergistic Matter World Model(Estimated Calculation Simulation)

The RNA World Hypothesis (RWH) posits that RNA alone initiated life, acting as both genetic material and catalyst. However, RNA’s chemical instability and limited catalytic efficiency challenge this view. The Matter World Hypothesis (MWH) proposes that life emerged from synergistic interactions among RNA, DNA, peptides, lipids, and catalysts in diverse
openaire   +1 more source

The Gut–Heart Axis in Systemic Sclerosis: Evidence From a Large Prospective Early Disease Cohort

Arthritis Care &Research, EarlyView.
Objective Cardiac involvement significantly impacts prognosis in systemic sclerosis (SSc), highlighting the need for early risk stratification. Gastrointestinal (GI) symptoms are common and often manifest early. Emerging data suggest a link between GI and cardiac manifestations, possibly through shared mechanisms like dysautonomia.
Francesca R. Di Ciommo, Ashish P. Balar, Aidan K. Strother, Subhash Kulkarni, Michael Hughes, Brian Skaug, Maureen D. Mayes, Shervin Assassi, Ali Y. Ayla, Zsuzsanna H. McMahan   +9 more
wiley   +1 more source

Molecular Dynamics Simulations with Diverse Nucleotides Refute RNA World Hypothesis, Supporting Synergistic Matter World Model(Estimated Calculation Simulation)

The RNA World Hypothesis (RWH) posits that RNA alone initiated life, acting as both genetic material and catalyst. However, RNA’s chemical instability and limited catalytic efficiency challenge this view. The Matter World Hypothesis (MWH) proposes that life emerged from synergistic interactions among RNA, DNA, peptides, lipids, and catalysts in diverse
openaire   +1 more source

Real‐World Safety and Effectiveness of JAK Inhibitors in Systemic Sclerosis: A Propensity‐Matched Study From the EUSTAR Cohort

Arthritis Care &Research, EarlyView.
Objective JAK inhibitors (JAKi) have shown promising effects in early‐phase studies of systemic sclerosis (SSc). We aimed to assess the safety and explore the effectiveness of JAKi compared to conventional immunosuppressants in SSc. Methods A longitudinal retrospective study of the European Scleroderma Trials and Research Group (EUSTAR) cohort was ...
Stefano Di Donato, Marie‐Elise Truchetet, Marco Minerba, Oliver Distler, Juan José Alegre Sancho, Yolanda Braun‐Moscovici, Christina Bergmann, Petros Sfikakis, Jeska K. de Vries‐Bouwstra, Murray Baron, Silvia Bellando‐Randone, Lorenzo Dagna, Christopher P. Denton, Madelon C. Vonk, Vanessa Smith, Ivan Castellvi, Gabriela Riemekasten, Andra Balanescu, Masataka Kuwana, Maria De Santis, Kamal Solanki, Anastas Batalov, Vahan Mukuchyan, Marco Matucci‐Cerinic, Yannick Allanore, Francesco Del Galdo, Michael Hughes, EUSTAR Collaborators   +27 more
wiley   +1 more source

Anorectal Dysfunction in Systemic Sclerosis: Clinical Phenotypes and Functional Patterns

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to characterize specific physiologic defects in anorectal dysfunction in systemic sclerosis (SSc) using anorectal manometry (ARM), evaluate associations with gastrointestinal (GI) and extraintestinal clinical phenotypes, and explore potential serologic markers for risk stratification.
Timothy Kaniecki, Alireza Amindarolzarbi, Tsion Abdi, John Clarke, Michael Hughes, Ami A. Shah, Zsuzsanna H. McMahan   +6 more
wiley   +1 more source