Results 131 to 140 of about 298 (200)

Coarse-Grained Molecular Dynamics and Enhanced Sampling Disprove RNA World Hypothesis, Supporting Synergistic Matter World Model(Estimated Calculation Simulation)

The RNA World Hypothesis (RWH) posits that RNA alone initiated life, serving as both genetic material and catalyst. However, RNA’s chemical instability and limited catalytic efficiency challenge this view. The Matter World Hypothesis (MWH) proposes that life emerged from synergistic interactions among RNA, DNA, peptides, lipids, and catalysts in ...
openaire   +1 more source

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

Advanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam, Seon Yeong Chae, Young Woo Kwon, Hye Jin Heo, Hye Rin Lee, Ji Hyeok Lee, Dong‐Wook Han, Yun Hak Kim, Suck Won Hong   +8 more
wiley   +1 more source

Validating the Matter World Hypothesis: Experimental Evidence for the Inevitable Coexistence and Selection of RNA and DNA Under Prebiotic Conditions

The Matter World Hypothesis posits that prebiotic evolution is governed by physical and chemical constraints, leading to the inevitable coexistence of RNA and DNA prior to biological selection. While theoretically articulated, this hypothesis is strongly supported by experimental synthesis and degradation studies that demonstrate the simultaneous ...
openaire   +2 more sources

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source

RNA Self-Replication in Protocells: Synergistic Catalysis and Evolutionary Dynamics under the Matter World Hypothesis(Estimated Calculation Simulation)

The Matter World Hypothesis (MWH) posits that life emerged through the synergistic interplay of Matter Desire, Environment, Time, and Natural Selection, transforming prebiotic matter into complex systems. Building on prior simulations of protocell stability, division, and energy transduction (Hashemi, 2025a-d), this study investigates RNA self ...
openaire   +2 more sources

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Advanced Functional Materials, EarlyView.
Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang   +16 more
wiley   +1 more source

Hydrogels Augmented With Artificial Sweeteners can Inhibit Multidrug‐Resistant Acinetobacter baumannii Growth and Biofilm Formation While Demonstrating Safety in Pre‐Clinical Pilot Human Trials

Advanced Healthcare Materials, EarlyView.
Using PVA–borax hydrogels as carriers for off‐the‐shelf artificial sweeteners to fight multidrug‐resistant A. baumannii. These soft, biocompatible hydrogels rapidly reduce bacterial viability within multidrug‐resistant A. baumannii biofilms by more than 99% within one hour and sustain antimicrobial activity over time, while demonstrating safety in both
Jie Han, Mohamed Soliman, Bin Zhang, Dominika Krawiel, Ronan R. McCarthy   +4 more
wiley   +1 more source

Dissipative Particle Dynamics and Molecular Dynamics Simulations Refute RNA World Hypothesis, Supporting Synergistic Matter World Model(Estimated Calculation Simulation)

The RNA World Hypothesis (RWH) posits that RNA alone initiated life, serving as both genetic material and catalyst. However, RNA’s chemical instability and limited catalytic efficiency challenge this view. The Matter World Hypothesis (MWH) proposes that life emerged from synergistic interactions among RNA, DNA, peptides, lipids, and catalysts in ...
openaire   +2 more sources

Molecular Dynamics Simulations with Advanced Ribosome-Peptide Interactions and Oxidative Damage Refute RNA World Hypothesis, Supporting Synergistic Matter World Model(Estimated Calculation Simulation)

The RNA World Hypothesis (RWH) posits that RNA alone initiated life as both genetic material and catalyst. However, its chemical instability, poor catalytic efficiency, and high mutation rates challenge this view. The Matter World Hypothesis (MWH) proposes that life emerged from synergistic interactions among RNA, DNA, peptides, lipids, and catalysts ...
openaire   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source