Results 181 to 190 of about 298 (200)
Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer
Advanced Science, EarlyView.The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu +13 more
wiley +1 more source
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The “Strong” RNA World Hypothesis: Fifty Years Old
Astrobiology, 2013This year marks the 50 th anniversary of a proposal by Alex Rich that RNA, as a single biopolymer acting in two capacities, might have supported both genetics and catalysis at the origin of life.
, Marc Neveu, Hyo-Joong Kim
exaly +3 more sources
Active centrum hypothesis: The origin of chiral homogeneity and the RNA-world
BioSystems, 2011I propose a hypothesis on the origin of chiral homogeneity of bio-molecules based on chiral catalysis. The first chiral active centre may have formed on the surface of complexes comprising metal ions, amino acids, other coenzymes and oligomers (short RNAs). The complexes must have been dominated by short RNAs capable of self-reproduction with ligation.
József Garay
exaly +3 more sources
Catalysis and Molecular Selection: The RNA World Hypothesis
Randy Wayne, Thomas G Owensexaly +2 more sources
The RNA World Hypothesis: Past Triumphs, Current Challenges and Future Questions
Savio Farias, Prosdocimi Fexaly +2 more sources
Some Consequences of the RNA World Hypothesis
Origins of life and evolution of the biosphere, 2003It is now generally accepted that our familiar biological world was preceded by an RNA world in which ribosome-catalyzed, nucleic-acid coded protein synthesis played no part. If the RNA world was the first biological world there is little that one can learn from biochemistry about prebiotic chemistry, except that the formation and polymerization of ...
openaire +2 more sources
Origins of Life and Evolution of Biospheres, 2011
The transitions to multicellularity mark the most pivotal and distinctive events in life's history on Earth. Although several transitions to "simple" multicellularity (SM) have been recorded in both bacterial and eukaryotic clades, transitions to complex multicellularity (CM) have only happened a few times in eukaryotes.
Lozada-Chavez, Irma +2 more
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The transitions to multicellularity mark the most pivotal and distinctive events in life's history on Earth. Although several transitions to "simple" multicellularity (SM) have been recorded in both bacterial and eukaryotic clades, transitions to complex multicellularity (CM) have only happened a few times in eukaryotes.
Lozada-Chavez, Irma +2 more
openaire +3 more sources
Journal of Theoretical Biology, 2002
Based on previous considerations published in J. theor. Biol., new analyses of the organization of the genetic system are reported in this paper. We show that theoretical considerations about the order observed in the genetic code table support the idea of a primitive self-aminoacylation process achieved by primordial tRNAs.
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Based on previous considerations published in J. theor. Biol., new analyses of the organization of the genetic system are reported in this paper. We show that theoretical considerations about the order observed in the genetic code table support the idea of a primitive self-aminoacylation process achieved by primordial tRNAs.
openaire +3 more sources
Bulletin of the Chemical Society of Japan, 2000
Abstract A new method for monitoring hydrothermal reactions on the millisecond time scale has been developed using a micro-tube flow reactor. The system was designed based on a high-pressure pump, a sample-loop injector, a narrow-bore size capillary, a cooling bath, back-pressure tubing, and a sampling port.
openaire +1 more source
Abstract A new method for monitoring hydrothermal reactions on the millisecond time scale has been developed using a micro-tube flow reactor. The system was designed based on a high-pressure pump, a sample-loop injector, a narrow-bore size capillary, a cooling bath, back-pressure tubing, and a sampling port.
openaire +1 more source