Results 191 to 200 of about 291,851 (290)

Engineered Living Systems With Self‐Organizing Neural Networks: From Anatomy to Behavior and Gene Expression

Advanced Science, EarlyView.
Ectodermal tissue excised from Xenopus embryos self‐organizes into a three‐dimensional mucociliary organoid. Here, we generate a neural variant, termed neurobot, by implanting neural precursor cells. Neurobots develop mature neurons, adopt distinct morphologies, exhibit more complex motility, and respond differentially to neuroactive compounds. Imaging
Haleh Fotowat, Laurie O'Neill, Léo Pio‐Lopez, Megan M. Sperry, Patrick Erickson, Tiffany Lin, Michael Levin   +6 more
wiley   +1 more source

Influence of body composition on the efficacy of nivolumab plus ipilimumab for metastatic clear cell renal cell carcinoma. [PDF]

J Immunother Cancer
Grewal K, Moura Nascimento Santos MJ, Chauhan PK, Yu K, Tannir NM, Mukhida SS, Venkatesh N, Shah AY, Zurita AJ, Johns AC, Campbell MT, Goswami S, Gao J, Jonasch E, McQuade JL, Alhalabi O, Msaouel P, Hahn AW.   +17 more
europepmc   +1 more source

Computational Estimation of 1,000,000 Monte Carlo Runs with 100 Division Events for 50-Nucleotide RNA/DNA and Diverse Peptides in the Matter World Hypothesis

The Matter World Hypothesis (MWH) proposes that life emerged through synergistic interactions among RNA, DNA, peptides, lipids, and minerals (RDPLE⁺) in prebiotic environments (hydrothermal vents, ice veins, wet-dry cycles). Previous simulations (150,000 Monte Carlo steps) demonstrated protocell viability but were limited in evolutionary scope.
openaire   +2 more sources

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Is the emergence of life and of agency expected? [PDF]

Philos Trans R Soc Lond B Biol Sci
Kauffman S, Roli A.
europepmc   +1 more source

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

Double-edged role of N6-methyladenosine reader YTH structural domain family protein 2 in neurological disorders: Molecular mechanisms and translational prospects. [PDF]

World J Exp Med
Liu YM, Liu M, Yuan H, Li B.
europepmc   +1 more source

Agent-Based Modeling of Protocell Evolution with 1000-Nucleotide RNA/DNA: Lineage Divergence and Proto-Translation Emergence under the Matter World Hypothesis

The Matter World Hypothesis (MWH) posits that life emerged through synergistic interactions among RNA, DNA, peptides, lipids, and catalytic extras in prebiotic environments. Traditional Monte Carlo simulations aggregate population-level dynamics, obscuring individual lineage trajectories and emergent phenomena like proto-translation.
openaire   +2 more sources

Temporal and Cell‐Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1

Advanced Science, EarlyView.
Chd1, the Drosophila homologue of mammalian CHD2 ‐ a gene linked to autism, epilepsy, and intellectual disability, is required for synaptic homeostatic plasticity. Chd1 in glia is necessary for the rapid induction of synaptic homeostasis, whereas Chd1 in motoneurons, muscle, and glia is critical for long‐term maintenance.
Danielle T. Morency, Tao Cui, Yimei Cai, Chloe Lok, Rachel E. Nokku, Ruoxian Huang, Grace L. Chu, Yumeng Xie, Saleem W. Abu‐Tayeh, Kaikai He, Chengjie Qiu, Junyi Wang, Paxton M. Paganelli, Ting Wang, Gabrielle Williams, Sreejith Nair, Huadong Pei, Dion K. Dickman, Stefano Vicini, Tingting Wang   +19 more
wiley   +1 more source

Three paradoxical paradigms of measles virus. [PDF]

PLoS Pathog
Clark SE, Sinn PL.
europepmc   +1 more source