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Some Consequences of the RNA World Hypothesis
Origins of life and evolution of the biosphere, 2003 It is now generally accepted that our familiar biological world was preceded by an RNA world in which ribosome-catalyzed, nucleic-acid coded protein synthesis played no part. If the RNA world was the first biological world there is little that one can learn from biochemistry about prebiotic chemistry, except that the formation and polymerization of ...
Leslie E. Orgel
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The “Strong” RNA World Hypothesis: Fifty Years Old
Astrobiology, 2013 This year marks the 50(th) anniversary of a proposal by Alex Rich that RNA, as a single biopolymer acting in two capacities, might have supported both genetics and catalysis at the origin of life. We review here both published and previously unreported experimental data that provide new perspectives on this old proposal.
Marc Neveu +2 more
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RNA World Hypothesis and the Origin of Life: Astrochemistry Perspective
, 2022 openalex +2 more sources
ChemBioChem, 2015 In the spring of the world: Reductive homologation of cyanidic precursors creates the carbon scaffold for multiple classes of biologically relevant compounds. This chemistry underpins a scenario for the formation of a protometabolism on the way to an RNA world.
Greg Springsteen
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Active centrum hypothesis: The origin of chiral homogeneity and the RNA-world
Biosystems, 2010 I propose a hypothesis on the origin of chiral homogeneity of bio-molecules based on chiral catalysis. The first chiral active centre may have formed on the surface of complexes comprising metal ions, amino acids, other coenzymes and oligomers (short RNAs). The complexes must have been dominated by short RNAs capable of self-reproduction with ligation.
József Garay
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The RNA World Hypothesis: Past Triumphs, Current Challenges and Future Questions
Sávio Torres de Farías +1 more
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Catalysis and Molecular Selection: The RNA World Hypothesis
Karl J. Niklas +2 more
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Origins of Life and Evolution of Biospheres, 2011 The transitions to multicellularity mark the most pivotal and distinctive events in life's history on Earth. Although several transitions to "simple" multicellularity (SM) have been recorded in both bacterial and eukaryotic clades, transitions to complex multicellularity (CM) have only happened a few times in eukaryotes.
Irma Lozada-Chávez +2 more
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Journal of Theoretical Biology, 2002 Based on previous considerations published in J. theor. Biol., new analyses of the organization of the genetic system are reported in this paper. We show that theoretical considerations about the order observed in the genetic code table support the idea of a primitive self-aminoacylation process achieved by primordial tRNAs.
J. Lehmann
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