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Monitoring Hydrothermal Reactions on the Millisecond Time Scale Using a Micro-Tube Flow Reactor and Kinetics of ATP Hydrolysis for the RNA World Hypothesis

Bulletin of the Chemical Society of Japan, 2000
Abstract A new method for monitoring hydrothermal reactions on the millisecond time scale has been developed using a micro-tube flow reactor. The system was designed based on a high-pressure pump, a sample-loop injector, a narrow-bore size capillary, a cooling bath, back-pressure tubing, and a sampling port.
Kunio Kawamura
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NASA's RNA World Experiments and the Matter World Hypothesis: A Comprehensive Critique

The RNA World Hypothesis (RWH) posits that self-replicating RNA molecules were the primary precursors to life, functioning as both genetic material and catalysts in Earth’s prebiotic environment. Supported by NASA’s Astrobiology Program, RWH experiments have simulated early Earth conditions, such as tidal pools (pH 6-6.5, 25-50°C, 0.5 M NaCl) and ...
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Matter World Hypothesis Origin of Life VI RNA World Hypothesis and 1989 Nobel Prize Chemistry

The Nobel Prize in Chemistry 1989 was awarded jointly to Sidney Altman and Thomas R. Cech "for their discovery of catalytic properties of RNA"
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Archaea and Computational Simulations Refute the RNA World Hypothesis, Strongly Confirm the Matter World Hypothesis

The RNA World Hypothesis (RWH), which posits RNA as the sole primordial molecule driving life’s origin, faces significant challenges due to RNA’s chemical instability, limited catalytic capacity, and inability to form stable protocells. In contrast, the Matter World Hypothesis (MWH) proposes that life emerged from synergistic interactions among RNA ...
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Matter World Hypothesis Origin of Life ( I-IV ) From Matter to Life Challenging the RNA World Hypothesis

The Matter World Hypothesis (MWH), introduced by Reza Hashemi in 2025, offers a compelling alternative. MWH envisions life’s origins as a collaborative effort among RNA, DNA, peptides, lipids, and catalysts (e.g., montmorillonite clay, Zn²⁺ ions) in a dynamic “matter soup.” This synergistic network, operating in diverse prebiotic environments like ...
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RNA-DNA-Protein-Environment Model: A Simulation Study Challenging the RNA World Hypothesis

The RNA World Hypothesis posits that RNA alone initiated life through self-replication and catalysis. However, its fragility under prebiotic conditions—such as UV radiation, temperature fluctuations, and reactive oxygen species—casts doubt on its sufficiency.
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An overview of real‐world data sources for oncology and considerations for research

Ca-A Cancer Journal for Clinicians, 2022
Lynne Penberthy, Donna R Rivera, Jennifer L Lund, Msph   +2 more
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Coupled Molecular Dynamics and Kinetic Modeling of RNA Replication Refute RNA World Hypothesis, Supporting Synergistic Matter World Model(Estimated Calculation Simulation)

The RNA World Hypothesis (RWH) posits that RNA alone initiated life, serving as both genetic material and catalyst. However, RNA’s chemical instability, poor catalytic efficiency, and high mutation rates challenge its evolvability. The Matter World Hypothesis (MWH) proposes that life emerged from synergistic interactions among RNA, DNA, peptides ...
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Statistical Refutation of the RNA World Hypothesis: Extensive Simulations of an RNA-Only Protocell in Prebiotic Environments

The RNA World hypothesis posits that RNA alone could sustain early life as both genetic and catalytic molecule. We challenge this by simulating a minimal 170-nt RNA protocell (70 nt functional + 100 nt rRNA; 30% A, 30% G, 20% C, 15% U, 5% inosine/pseudouridine; ΔΔG -8.5 to -9.5 kcal/mol) in hydrothermal vents (80 ± 15°C, pH 6.0 ± 0.5, oxidative stress ...
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Molecular Dynamics Simulations with Diverse Nucleotides Refute RNA World Hypothesis, Supporting Synergistic Matter World Model(Estimated Calculation Simulation)

The RNA World Hypothesis (RWH) posits that RNA alone initiated life, acting as both genetic material and catalyst. However, RNA’s chemical instability and limited catalytic efficiency challenge this view. The Matter World Hypothesis (MWH) proposes that life emerged from synergistic interactions among RNA, DNA, peptides, lipids, and catalysts in diverse
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