Results 261 to 270 of about 292,607 (304)

Polymeric Protocell Dynamics in Abiotic Conditions: Refuting the RNA World Hypothesis(Estimated Calculating Simulation)

The RNA World Hypothesis (RWH) posits that polymeric RNA, exemplified by catalytic ribozymes like the ribosome’s peptidyl transferase, served as the origin of life, with DNA emerging as a product of RNA-directed processes. This study challenges RWH by demonstrating the instability of both free and polymeric RNA under abiotic conditions and the ...
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Cancer risk among World Trade Center rescue and recovery workers: A review

Ca-A Cancer Journal for Clinicians, 2022
Paolo Boffetta, Charles B Hall, Andrew C Todd   +2 more
exaly  

Coarse-Grained Molecular Dynamics and Enhanced Sampling Disprove RNA World Hypothesis, Supporting Synergistic Matter World Model(Estimated Calculation Simulation)

The RNA World Hypothesis (RWH) posits that RNA alone initiated life, serving as both genetic material and catalyst. However, RNA’s chemical instability and limited catalytic efficiency challenge this view. The Matter World Hypothesis (MWH) proposes that life emerged from synergistic interactions among RNA, DNA, peptides, lipids, and catalysts in ...
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Dissipative Particle Dynamics and Molecular Dynamics Simulations Refute RNA World Hypothesis, Supporting Synergistic Matter World Model(Estimated Calculation Simulation)

The RNA World Hypothesis (RWH) posits that RNA alone initiated life, serving as both genetic material and catalyst. However, RNA’s chemical instability and limited catalytic efficiency challenge this view. The Matter World Hypothesis (MWH) proposes that life emerged from synergistic interactions among RNA, DNA, peptides, lipids, and catalysts in ...
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Microsecond-to-Millisecond Simulations and Kinetic Modeling Refute RNA World Hypothesis, Supporting Synergistic Matter World Model(Estimated Calculation Simulation)

The RNA World Hypothesis (RWH) posits that RNA alone initiated life, acting as both genetic material and catalyst. However, RNA’s chemical instability and limited catalytic efficiency challenge this view. The Matter World Hypothesis (MWH) proposes that life emerged from synergistic interactions among RNA, DNA, peptides, lipids, and catalysts in diverse
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Older adult participation in cancer clinical trials: A systematic review of barriers and interventions

Ca-A Cancer Journal for Clinicians, 2021
Mina S Sedrak, Rachel A Freedman, Aminah Jatoi   +2 more
exaly  

Statistical Evaluation of a Ribosome-Only Protocell in Prebiotic Environments: Implications for the RNA World Hypothesis

The RNA World hypothesis posits that RNA-based systems, such as ribosomes, could sustain early life without additional molecular support. We test this by simulating a protocell composed solely of a modern ribosome (large and small subunits, ~4,500 nt rRNA, excluding mRNA, tRNA, proteins, or other elements) in hydrothermal vents (80 ± 15°C, pH 6.0 ± 0.5,
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Circulating tumor DNA in advanced solid tumors: Clinical relevance and future directions

Ca-A Cancer Journal for Clinicians, 2021
Michael L Cheng, Glenn J Hanna, Heather A Parsons   +2 more
exaly  

A systematic review of rehabilitation and exercise recommendations in oncology guidelines

Ca-A Cancer Journal for Clinicians, 2021
Nicole L Stout, Daniel Santa Mina, Kathleen Doyle Lyons   +2 more
exaly  

Abiotic Co-Production of RNA and DNA in Model Protocells: Challenging the RNA World Hypothesis with Meisner et al.'s Methodology

The RNA World Hypothesis (RWH) posits that RNA, with its genetic and catalytic capabilities, was the primordial self-replicating molecule, with DNA emerging as an RNA-derived product. Meisner et al. (2019) [1] supported RWH by demonstrating nonenzymatic RNA synthesis in model protocells, achieving ribonucleotide yields of ~2–5% under prebiotic ...
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