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Molecular Dynamics Simulations with Multiple ROS Types and Photochemical Effects Refute RNA World Hypothesis, Supporting Synergistic Matter World Model(Estimated Calculation Simulation)

The RNA World Hypothesis (RWH) posits that RNA alone initiated life, serving as both genetic material and catalyst. However, RNA’s susceptibility to reactive oxygen species (ROS) and photochemical damage challenges its viability. The Matter World Hypothesis (MWH) proposes that life emerged from synergistic interactions among RNA, DNA, peptides, lipids,
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Molecular Dynamics Simulations with Advanced Ribosome-Peptide Interactions and Oxidative Damage Refute RNA World Hypothesis, Supporting Synergistic Matter World Model(Estimated Calculation Simulation)

The RNA World Hypothesis (RWH) posits that RNA alone initiated life as both genetic material and catalyst. However, its chemical instability, poor catalytic efficiency, and high mutation rates challenge this view. The Matter World Hypothesis (MWH) proposes that life emerged from synergistic interactions among RNA, DNA, peptides, lipids, and catalysts ...
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Outdoor air pollution and cancer: An overview of the current evidence and public health recommendations

Ca-A Cancer Journal for Clinicians, 2020
Michelle C Turner   +2 more
exaly  

RNA Self-Replication in Protocells: Synergistic Catalysis and Evolutionary Dynamics under the Matter World Hypothesis(Estimated Calculation Simulation)

The Matter World Hypothesis (MWH) posits that life emerged through the synergistic interplay of Matter Desire, Environment, Time, and Natural Selection, transforming prebiotic matter into complex systems. Building on prior simulations of protocell stability, division, and energy transduction (Hashemi, 2025a-d), this study investigates RNA self ...
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2016 US lymphoid malignancy statistics by World Health Organization subtypes

Ca-A Cancer Journal for Clinicians, 2016
Lauren R Teras   +2 more
exaly  

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Ca-A Cancer Journal for Clinicians, 2018
Frank Bray   +2 more
exaly  

Molecular Dynamics Simulations Reveal RNA's Instability and the Necessity of Synergistic Networks in Prebiotic Environments. A Molecular Dynamics Simulation to Refute the RNA World Hypothesis(Estimated Calculation Simulation)

The RNA World Hypothesis (RWH) posits that RNA alone was sufficient to initiate life, acting as both genetic material and catalyst. However, RNA’s chemical instability and limited catalytic efficiency challenge this view. The Matter World Hypothesis (MWH) proposes that life emerged from synergistic interactions among RNA, DNA, peptides, lipids, and ...
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Breast cancer and circadian disruption from electric lighting in the modern world

Ca-A Cancer Journal for Clinicians, 2014
Richard G Stevens   +2 more
exaly  

Agent-Based Modeling of Protocell Evolution with 1000-Nucleotide RNA/DNA: Lineage Divergence and Proto-Translation Emergence under the Matter World Hypothesis

The Matter World Hypothesis (MWH) posits that life emerged through synergistic interactions among RNA, DNA, peptides, lipids, and catalytic extras in prebiotic environments. Traditional Monte Carlo simulations aggregate population-level dynamics, obscuring individual lineage trajectories and emergent phenomena like proto-translation.
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Computational Validation of the Matter World Hypothesis: Statistical Evidence for RNA Elimination and DNA Persistence Under Prebiotic Oxidative Stress(Estimated Calculating Simulation )

The Matter World Hypothesis (MWH) proposes co-evolution of multiple molecular systems in prebiotic environments, challenging the RNA World Hypothesis. Using computational modeling and Monte Carlo statistical validation, we confirm MWH claims from Hashemi (2025) studies.
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