A Candidate RNAi Screen Reveals Diverse RNA-Binding Protein Phenotypes in Drosophila Flight Muscle [PDF]
, 2021 Shao-Yen Kao +8 more
openalex +1 more source
Advanced Science, EarlyView.Acquired sensorineural hearing loss is primarily caused by the damage or loss of cochlear hair cells, induced by factors such as noise exposure and ototoxic drugs. The deficiency of apoptosis‐inducing gene Cidea in Cidea KO mice or by delivering CRISPR/SlugCas9‐HF via AAV to edit Cidea effectively alleviated hair cell damage and hearing loss caused by ...
Shasha Zhang +14 more
wiley +1 more source
The Risks of miRNA Therapeutics: In a Drug Target Perspective
Drug Design, Development and Therapy, 2021 Song Zhang, 1, 2 Zhujun Cheng, 3 Yanan Wang, 1 Tianyu Han 1 1Jiangxi Institute of Respiratory Disease, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, People’s Republic of China; 2College of Pharmaceutical Sciences ...
Zhang S, Cheng Z, Wang Y, Han T
doaj
Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10) [PDF]
, 2008 Lawrence C. S. Tam +14 more
openalex +1 more source
Increased RNAi Efficacy in Spodoptera exigua via the Formulation of dsRNA With Guanylated Polymers
Frontiers in Physiology, 2018 Lepidoptera comprise some of the most devastating herbivorous pest insects worldwide. One of the most promising novel pest control strategies is exploiting the RNA interference (RNAi) mechanism to target essential genes for knockdown and incite toxic ...
O. Christiaens +5 more
semanticscholar +1 more source
Osteoclast‐Derived SLIT3 Mediates Osteoarthritis Pain and Degenerative Changes
Advanced Science, EarlyView.In TMJ‐OA, osteoclasts play a significant role in promoting the growth of sensory nerves at the osteochondral interface. In early OA, TRAP+ osteoclast‐derived SLIT3 induces sensory nerve growth into the condylar cartilage. This nerve growth facilitates the development of pain associated with OA.
Weiwei Zhu +13 more
wiley +1 more source
Inhibition of Glycogen Synthase II with RNAi Prevents Liver Injury in Mouse Models of Glycogen Storage Diseases [PDF]
, 2018 Natalie W. Pursell +19 more
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Advanced Science, EarlyView.IR‐induced dysbiosis depletes P. coprophilus and its metabolite 6‐methyluracil, leading to disinhibition of the IDO1‐Kyn‐AHR axis. This results in sustained fibroblast activation and collagen deposition, driving radiation induced intestinal fibrosis. ABSTRACT Therapeutic options for radiation‐induced intestinal fibrosis (RIF) remain limited. This study
Jiaxin Zhang +11 more
wiley +1 more source
A kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiation [PDF]
, 2015 Sami Benzina +9 more
openalex +1 more source
A nuclease specific to lepidopteran insects suppresses RNAi
Journal of Biological Chemistry, 2018 More than 70% of all agricultural pests are insects in the order Lepidoptera, which, unlike other related insect orders, are not very sensitive to RNAi, limiting genetic studies of this insect group.
Ruobing Guan +6 more
semanticscholar +1 more source