Results 141 to 150 of about 195,676 (344)

High-throughput reverse genetics: RNAi screens in Caenorhabditis elegans. [PDF]

, 2001
Cornelia I. Bargmann
openalex   +1 more source

Update on Gene Therapy in the Treatment of Hereditary Hearing Loss

Sensory Neuroscience, EarlyView.
Gene therapy is a promising therapeutic approach for genetic disorders, including three major gene therapy strategies: gene replacement, gene suppression, and gene editing. After transmitting genes to the inner ear through appropriate pathways, repair the cochlea in order to achieve the goal of treating hereditary hearing loss.
Weiwei He, Shanying Han, Xinghong Liu, Xiaotong Huang, Wen Yang, Xinghua Tang, Chuan Dong, Jiangang Fan   +7 more
wiley   +1 more source

Targeting the SOD1‒MMP‐2‒COLXVII axis: A therapeutic strategy for age‐related tissue degeneration

VIEW, EarlyView.
Our work identifies a novel role for MMP‐2 in driving senescence‐associated skin and muscle degeneration through ECM degradation. We demonstrate that inhibiting MMP‐2 activity restores tissue integrity by preserving COLXVII, revealing a new therapeutic pathway for combating oxidative stress‐induced tissue aging. Using both mammalian and nematode models,
Juewon Kim, Shuichi Shibuya, Masahiko Terajima, Yuki Taga, Kazunori Mizuno, Eunji Lee, Seokwon Han, Woo‐Young Seo, Takahiko Shimizu   +8 more
wiley   +1 more source

Identification of a 90-kDa polypeptide which associates with adenovirus VA RNAI and is phosphorylated by the double-stranded RNA-dependent protein kinase

, 1989
Andrew P. Rice, Matthew J. Kostura, Michael B. Mathews   +2 more
openalex   +1 more source

An epigenomic threshold hypothesis for integrating dynamic environmental signals into functional models of developmental polyphenisms

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Interactions between developing embryos and a multitude of environmental factors (e.g. climate, nutrition, social cues, stress and anthropogenic contaminants) underlie adaptive and non‐adaptive developmental plasticity and carry broad implications across ecological ...
Benjamin B. Parrott, Samantha L. Bock
wiley   +1 more source

Genetically Modified Wheat, Wheat Intolerance, and Food Safety Concerns

European Medical Journal Allergy & Immunology, 2018
Wheat intolerance is a common problem for certain individuals. A gluten-free diet is the only option for people with wheat-associated disorders (WAD) to manage their condition.
Atul Munish Chander, Sanjay Kumar Bhadada, Devinder Kumar Dhawan   +2 more
doaj  

Lentiviral-mediated Smad4 RNAi induced anti-proliferation by p16 up-regulation and apoptosis by caspase 3 down-regulation in hepatoma SMMC-7721 cells

, 1994
Ji
openalex   +2 more sources

RNAi Targeting an Animal Virus [PDF]

, 2002
Brett D. Lindenbach, Charles M. Rice
openalex   +1 more source

Exploring the impact of a chemical disinfectant and an antiviral drug for RNA virus management in the Mediterranean fruit fly mass‐rearing

Insect Science, EarlyView.
Abstract The Mediterranean fruit fly is an agricultural pest of a wide variety of fruit crops. An effective method to counteract them in the field is through the application of the sterile insect technique, which requires the mass‐production of sterile males.
Luis Hernández‐Pelegrín, Pablo García‐Castillo, Marta Catalá‐Oltra, Óscar Dembilio, Vera I.D. Ros, Salvador Herrero   +5 more
wiley   +1 more source

Identification and functional analysis of six DNAJ genes from Myzus persicae (Hemiptera: Aphididae) in response to UV-B stress

European Journal of Entomology
Ultraviolet B (UV-B) is a significant environmental factor affecting insect development, survival, and reproduction. DNAJ proteins are molecular chaperones found ubiquitously in insects that are crucial for their adaptation to environmental stresses ...
Long-Chun HE, Jian-Yu MENG, Guy SMAGGHE, Chang-Li YANG, Xue TANG, Chang-Yu ZHANG   +5 more
doaj   +1 more source