Results 181 to 190 of about 195,676 (344)
Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi
Thomas A. Volpe+5 more
semanticscholar +1 more source
Ethanol‐induced Nrf2 suppression in the lung is mediated by AP‐1‐driven expression of miR‐144
Previously, we determined that ethanol suppresses Nrf2 and thereby inhibits antioxidant and immune defenses in the lung. Clinically, individuals with AUD are vulnerable to pneumonia and acute lung injury. In this new experimental study, we report that ethanol inhibits Nrf2 in rat lung cells via the induction of miR‐144 in a mechanism dependent on the ...
Viranuj Sueblinvong+4 more
wiley +1 more source
CCR5 predicts neurotoxicity in CAR‐T‐cell therapy
Patients undergoing chimeric antigen receptor T (CAR T)‐cell therapy are at risk of developing immune effector cell‐associated neurotoxicity syndrome (ICANS). We observed an upregulation of CCR5 and CCR2 expression in CD4+ T cells among patients who developed ICANS.
Ayal Rozenberg+12 more
wiley +1 more source
▪ Background and Purpose NLRP3 is up‐regulated in inflammatory and autoimmune diseases. The development of NLRP3 inhibitors is challenged by the identification of compounds with distinct mechanisms of action avoiding side effects and toxicity. Triptolide is a natural product with multiple anti‐inflammatory activities, but a narrow therapeutic window ...
Mo‐Yu Ding+5 more
wiley +1 more source
Immuno-metabolic stress responses control longevity from mitochondrial translation inhibition in C. elegans. [PDF]
Hu IM+11 more
europepmc +1 more source
RNAi technology and its use in studying the function of nuclear receptors and coregulators [PDF]
Haijun Zhou+2 more
openalex +1 more source