Results 181 to 190 of about 330,568 (380)

Autophagy Plays a Suppressive Role in Bladder Tumor Formation in an Orthotopic Mouse Model and Bladder Cancer Patient Specimens

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Autophagy plays either a suppressing or promoting role during tumor development. Clarifying the role of autophagy in bladder tumorigenesis both in vitro and in vivo is crucial for developing novel therapeutic strategies through manipulating autophagy activity.
Wan‐Ting Kuo, Chin‐Chen Pan, Yi‐Wen Liu, Nan‐Haw Chow, Hong‐Lin Cheng, Shan‐Ying Wu, Sheng‐Hui Lan, Chih‐Peng Chang, Hsiao‐Sheng Liu   +8 more
wiley   +1 more source

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, EarlyView.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Peer Review #1 of "Addressing the challenges of symbiont-mediated RNAi in aphids (v0.1)"

, 2023
Katherine Elston, Gerald P. Maeda, Julie Perreau, Jeffrey E. Barrick, R Bansal, A Michel, P Baumann, N Moran, L Baumann, L Brutscher, K Daughenbaugh, M Flenniken, S Bustin, M Cao, J Gatehouse, E Fitches, O Christiaens, L Swevers, G Smagghe, S Chung, X Jing, Y Luo, A Douglas, A Coleman, Rhmm Wouters, S Mugford, S Hogenhout, S Dasgupta, L Fernandez, L Kameyama, T Inada, Y Nakamura, A Pappas, D Court, C-A Dedryver, Le Ralec, A Fabre, F, B-Y Ding, J Niu, F Shang, L Yang, T-Y Chang, J-J Wang, K Elston, J Perreau, G Maeda, N Moran, J Barrick, J Fan, Y Zhang, F Francis, D Cheng, J Sun, J Chen, G Febvay, B Delobel, Y Rahb, A Ghodke, R Good, J Golz, D Russell, O Edwards, Robin, A Ghosal, B Upadhyaya, J Fritz, A Heintz-Buschart, M Desai, D Yusuf, D Huang, A Baumuratov, K Wang, D Galas, P Wilmes, S Goodfellow, D Zhang, M-B Wang, R Zhang, M Grantham, J Brisson, H Huvenne, G Smagghe, S Jacques, J Reidy-Crofts, J Sperschneider, L Kamphuis, L Gao, O Edwards, K Singh, P Lariviere, S Leonard, R Horak, J Powell, J Barrick, H Lee, S Leonard, J Powell, J Perutka, P Geng   +99 more
openalex   +2 more sources

493 PH-804, an INTASYL self-delivering RNAi compound that targets TIGIT enhances NK cell cytotoxicity to tumor cells [PDF]

, 2022
Melissa Maxwell, Dingxue Yan, Brianna Rivest, Andrew R. Boone, Shenghua Zhou, Benjamin Cuiffo, James Cardia, Simon P. Fricker   +7 more
openalex   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Protocol for Establishing a Multiplex Image-based Autophagy RNAi Screen in Cell Cultures

, 2017
Jennifer Jung, Christian Behrends
openalex   +1 more source

Regulatory mechanisms of reproduction in locusts and grasshoppers

New Plant Protection, EarlyView.
Regulatory networks composed of numerous coding and noncoding genes play crucial roles in the reproduction of locusts and grasshoppers. This review integrates mechanistic advances in reproductive regulation, highlighting environmentally adaptive pathways and providing prospective targets for eco‐friendly pesticides.
Jing He, Jiliang Wang, Xinran Wang
wiley   +1 more source

Enhancing safety and efficacy of RNAi-based gene therapy for the treatment of chronic hepatitis B

, 2014
Thomas Michler, Stefan Mockenhaupt, Stefanie Große, Dirk Grimm, Ulrike Protzer   +4 more
openalex   +1 more source

RNAi on the Apoptosis TRAIL [PDF]

, 2003
Muneesh Tewari, Marc Vidal
openalex   +1 more source

Juvenile hormone‐mediated accelerated post‐flight recovery of ovarian development in Loxostege sticticalis (Lepidoptera: Crambidae)

New Plant Protection, EarlyView.
Flight in female beet webworms (Loxostege sticticalis) promotes an increase in feeding, thereby enhancing abdominal energy reserves. Following flight, the flight muscles undergo accelerated histolysis, and the energy substances undergoing histolysis are redirected to the ovaries. These two processes collectively promote ovarian development.
Yu Gao, Yunxia Cheng, Wenyi Song, Lei Zhang, Dianjie Xie, Xingfu Jiang   +5 more
wiley   +1 more source