Results 181 to 190 of about 195,676 (344)

Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi

open access: yesScience, 2002
Thomas A. Volpe   +5 more
semanticscholar   +1 more source

Ethanol‐induced Nrf2 suppression in the lung is mediated by AP‐1‐driven expression of miR‐144

open access: yesAlcohol, Clinical and Experimental Research, EarlyView.
Previously, we determined that ethanol suppresses Nrf2 and thereby inhibits antioxidant and immune defenses in the lung. Clinically, individuals with AUD are vulnerable to pneumonia and acute lung injury. In this new experimental study, we report that ethanol inhibits Nrf2 in rat lung cells via the induction of miR‐144 in a mechanism dependent on the ...
Viranuj Sueblinvong   +4 more
wiley   +1 more source

CCR5 predicts neurotoxicity in CAR‐T‐cell therapy

open access: yesBritish Journal of Haematology, EarlyView.
Patients undergoing chimeric antigen receptor T (CAR T)‐cell therapy are at risk of developing immune effector cell‐associated neurotoxicity syndrome (ICANS). We observed an upregulation of CCR5 and CCR2 expression in CD4+ T cells among patients who developed ICANS.
Ayal Rozenberg   +12 more
wiley   +1 more source

RNAi: an ever-growing puzzle [PDF]

open access: green, 2003
Ahmet M. Denli, Gregory J. Hannon
openalex   +1 more source

Discovery of natural product derivative triptolidiol as a direct NLRP3 inhibitor by reducing K63‐specific ubiquitination

open access: yesBritish Journal of Pharmacology, EarlyView.
▪ Background and Purpose NLRP3 is up‐regulated in inflammatory and autoimmune diseases. The development of NLRP3 inhibitors is challenged by the identification of compounds with distinct mechanisms of action avoiding side effects and toxicity. Triptolide is a natural product with multiple anti‐inflammatory activities, but a narrow therapeutic window ...
Mo‐Yu Ding   +5 more
wiley   +1 more source

Immuno-metabolic stress responses control longevity from mitochondrial translation inhibition in C. elegans. [PDF]

open access: yesNat Commun
Hu IM   +11 more
europepmc   +1 more source

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