A genome-wide genetic screen identifies a novel kDNA replication protein in trypanosomes. [PDF]
Miskinyte M +9 more
europepmc +1 more source
A lipid‐sensitive food choice behavior influences aging outcomes from a longevity‐promoting diet
C. elegans are exposed to a variety of bacteria in their natural environment and must be able to distinguish between beneficial and detrimental food sources. We show that C. elegans exposed to the bacterium from their natural habitat, Methylobacterium, disrupts lipid homeostasis, causing worms to avoid this bacterial species and choose the laboratory ...
Nicole L. Stuhr +4 more
wiley +1 more source
Phosphatidylinositol transfer protein-1 integrates insulin/IGF-1 and TOR signaling to negatively regulate lifespan and healthspan in Caenorhabditis elegans. [PDF]
Lin YH +10 more
europepmc +1 more source
Aedes aegypti females were significantly repelled by both volatile DEET and citronella oil in comparison to control (ethanol‐exposed) mosquitoes. Global gene expression changes were largest in the mosquito mouthparts, with notable downregulation of the three subunits comprising the mosquito CO2 receptor (Gr1, 2 and 3).
Ivan Drahun +3 more
wiley +1 more source
Knockdown of Gasdermin D protects hippocampal neurons by regulating both pyroptosis and ferroptosis in a rat model of status epilepticus. [PDF]
Feng F, Wang H, Tian Y, Luo R, Cai Q.
europepmc +1 more source
Malaria mosquito antimicrobial defence requires immunity and detoxification gene regulation by Lola
Malaria mosquito antimicrobial defence requires upregulation of lola. Attenuation of lola in the midgut of Anopheles albimanus mosquitoes inhibits the upregulation of immunity genes induced by challenge. Putative target genes of the Lola transcription factor were revealed by lola attenuation, including Cecropin‐C, Draper, PPAF2, Clip‐domain serine ...
Heidi Espadas‐Álvarez +1 more
wiley +1 more source
SIN-3 coregulator maintains adaptive capacity to different diets in Caenorhabditis elegans through vitamin B12. [PDF]
Palladino F, Bedet C.
europepmc +1 more source
RNAi-Mediated Silencing of vATPase Subunit E Impairs Larval Development in <i>Plutella xylostella</i>, and Virtual Screening Identifies a Potential Inhibitor. [PDF]
Yu X +12 more
europepmc +1 more source
Tumor suppressor function of SHMT in a Drosophila Ras<sup>V12</sup>Dlg<sup>RNAi</sup> model: DNA damage and synergistic gene-nutrient interaction with PLP. [PDF]
Angioli C +7 more
europepmc +1 more source

