Results 211 to 220 of about 148,184 (260)

Experimental Approach to Moyamoya Angiopathy: Insights into Vascular Cell Crosstalk. [PDF]

open access: yesCells
Gorla G   +13 more
europepmc   +1 more source

RNAi in Plasmodium

Current Pharmaceutical Design, 2014
RNA interference (RNAi) has quickly proven to be an immensely useful tool for studying gene function and validation of potential drug targets in almost all organisms that possess the required set of proteins of the interference pathway. In protozoan parasites like Plasmodium, Toxoplasma, Entamoeba, Giardia, Trypanosoma, and Leishmania, this set of ...
Mueller, Ann-Kristin   +2 more
openaire   +2 more sources

Engineering lymphocytes with RNAi

Advanced Drug Delivery Reviews, 2019
Lymphocytes are the gatekeepers of the body's immune system and are involved in pathogenesis if their surveillance is stalled by inhibitory molecules or when they act as mediators for viral entry. Engineering lymphocytes in order to restore their functions is an unmet need in immunological disorders, cancer and in lymphotropic viral infections ...
Ramishetti, Srinivas, Peer, Dan
openaire   +2 more sources

Conditional RNAi in mice

Methods, 2011
RNA interference (RNAi)-mediated gene knockdown has developed into a routine method to assess gene function in cultured mammalian cells in a fast and easy manner. For the use of RNAi in mice, short hairpin (sh) RNAs expressed stably from the genome are a fast alternative to conventional knockout approaches.
Aljoscha, Kleinhammer   +3 more
openaire   +2 more sources

A Targeted RNAi-of-RNAi Strategy to Overcome Nuclease-Mediated RNAi Suppression and Enhance RNAi Efficacy in Lepidoptera Pest, Cydia Pomonella

Journal of Agricultural and Food Chemistry
The codling moth has developed resistance to chemical insecticides and biological agents, necessitating alternative control strategies. RNA interference (RNAi) offers considerable potential. However, variable efficacy across target genes remains a major barrier in lepidopterans.
Xiaojiang Li   +8 more
openaire   +2 more sources

RNAi: Design and Analysis

Current Protocols in Bioinformatics, 2004
AbstractRNAi is a novel genetic tool that is poised to revolutionize the study of genetics and gene networks. Use of this tool requires knowledge of the underlying mechanisms and application of this knowledge to the construction of a gene‐silencing library. This unit discusses approaches to rational design of this library and its use in experiments. It
openaire   +2 more sources

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