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RNAi in Plasmodium

Current Pharmaceutical Design, 2014
RNA interference (RNAi) has quickly proven to be an immensely useful tool for studying gene function and validation of potential drug targets in almost all organisms that possess the required set of proteins of the interference pathway. In protozoan parasites like Plasmodium, Toxoplasma, Entamoeba, Giardia, Trypanosoma, and Leishmania, this set of ...
Mueller, Ann-Kristin   +2 more
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Engineering lymphocytes with RNAi

Advanced Drug Delivery Reviews, 2019
Lymphocytes are the gatekeepers of the body's immune system and are involved in pathogenesis if their surveillance is stalled by inhibitory molecules or when they act as mediators for viral entry. Engineering lymphocytes in order to restore their functions is an unmet need in immunological disorders, cancer and in lymphotropic viral infections ...
Ramishetti, Srinivas, Peer, Dan
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Conditional RNAi in mice

Methods, 2011
RNA interference (RNAi)-mediated gene knockdown has developed into a routine method to assess gene function in cultured mammalian cells in a fast and easy manner. For the use of RNAi in mice, short hairpin (sh) RNAs expressed stably from the genome are a fast alternative to conventional knockout approaches.
Aljoscha, Kleinhammer   +3 more
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