Results 221 to 230 of about 147,575 (261)
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Trends in Biotechnology, 2004
Synthetic small interfering RNA (siRNA) has become a valuable tool for investigating gene function in cell culture. This success has led to high expectations for siRNA as a tool for in vivo investigation and as a platform for therapeutic development.
Zain, Paroo, David R, Corey
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Synthetic small interfering RNA (siRNA) has become a valuable tool for investigating gene function in cell culture. This success has led to high expectations for siRNA as a tool for in vivo investigation and as a platform for therapeutic development.
Zain, Paroo, David R, Corey
openaire +2 more sources
Journal of Agricultural and Food Chemistry
The codling moth has developed resistance to chemical insecticides and biological agents, necessitating alternative control strategies. RNA interference (RNAi) offers considerable potential. However, variable efficacy across target genes remains a major barrier in lepidopterans.
Xiaojiang Li +8 more
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The codling moth has developed resistance to chemical insecticides and biological agents, necessitating alternative control strategies. RNA interference (RNAi) offers considerable potential. However, variable efficacy across target genes remains a major barrier in lepidopterans.
Xiaojiang Li +8 more
openaire +2 more sources
2004
By introducing double-stranded RNAs (dsRNAs), it was shown that mRNAs that share sequences are destroyed, and that the translation step is severely downregulated (RNAi). This technique was demonstrated to be a very powerful tool for reverse genetics in Caenorhabditis elegans. However, studies have shown that RNAi can be achieved in living mice. In this
Hidetoshi, Hasuwa, Masaru, Okabe
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By introducing double-stranded RNAs (dsRNAs), it was shown that mRNAs that share sequences are destroyed, and that the translation step is severely downregulated (RNAi). This technique was demonstrated to be a very powerful tool for reverse genetics in Caenorhabditis elegans. However, studies have shown that RNAi can be achieved in living mice. In this
Hidetoshi, Hasuwa, Masaru, Okabe
openaire +2 more sources
Current Protocols in Bioinformatics, 2004
AbstractRNAi is a novel genetic tool that is poised to revolutionize the study of genetics and gene networks. Use of this tool requires knowledge of the underlying mechanisms and application of this knowledge to the construction of a gene‐silencing library. This unit discusses approaches to rational design of this library and its use in experiments. It
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AbstractRNAi is a novel genetic tool that is poised to revolutionize the study of genetics and gene networks. Use of this tool requires knowledge of the underlying mechanisms and application of this knowledge to the construction of a gene‐silencing library. This unit discusses approaches to rational design of this library and its use in experiments. It
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Molecular BioSystems, 2006
Abstract The commercial potential of RNAi is assessed on the basis of successful translation of technology into applications in three areas: (1) drug discovery and research—currently the biggest segment; (2) potential therapeutic applications; and (3) the role of microRNA in molecular diagnostics.
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Abstract The commercial potential of RNAi is assessed on the basis of successful translation of technology into applications in three areas: (1) drug discovery and research—currently the biggest segment; (2) potential therapeutic applications; and (3) the role of microRNA in molecular diagnostics.
openaire +2 more sources