Results 261 to 270 of about 267,874 (284)
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Current Pharmaceutical Design, 2014
RNA interference (RNAi) has quickly proven to be an immensely useful tool for studying gene function and validation of potential drug targets in almost all organisms that possess the required set of proteins of the interference pathway. In protozoan parasites like Plasmodium, Toxoplasma, Entamoeba, Giardia, Trypanosoma, and Leishmania, this set of ...
Mueller, Ann-Kristin +2 more
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RNA interference (RNAi) has quickly proven to be an immensely useful tool for studying gene function and validation of potential drug targets in almost all organisms that possess the required set of proteins of the interference pathway. In protozoan parasites like Plasmodium, Toxoplasma, Entamoeba, Giardia, Trypanosoma, and Leishmania, this set of ...
Mueller, Ann-Kristin +2 more
openaire +2 more sources
Engineering lymphocytes with RNAi
Advanced Drug Delivery Reviews, 2019Lymphocytes are the gatekeepers of the body's immune system and are involved in pathogenesis if their surveillance is stalled by inhibitory molecules or when they act as mediators for viral entry. Engineering lymphocytes in order to restore their functions is an unmet need in immunological disorders, cancer and in lymphotropic viral infections ...
Ramishetti, Srinivas, Peer, Dan
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Current Opinion in Chemical Biology, 2001
In many species, double-stranded RNA can specifically and effectively silence genes. This newly discovered biological phenomenon, called RNA interference (RNAi), has practical implications for functional genomics. As shown by two recent reports, RNAi provides a rapid method to test the function of genes in the nematode Caenorhabditis elegans; most of ...
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In many species, double-stranded RNA can specifically and effectively silence genes. This newly discovered biological phenomenon, called RNA interference (RNAi), has practical implications for functional genomics. As shown by two recent reports, RNAi provides a rapid method to test the function of genes in the nematode Caenorhabditis elegans; most of ...
openaire +2 more sources
Science, 2003
Genes are silenced when tiny regulatory RNAs bind to target messenger RNAs. But it is becoming clear that RNA interference goes beyond these interactions. In their perspective, [Matzke and Matzke][1] discuss recent work ([Schramke and Allshire][2]) that shows that the silencing pathway can induce heterochromatin formation in DNA that is normally ...
Marjori, Matzke, Antonius J M, Matzke
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Genes are silenced when tiny regulatory RNAs bind to target messenger RNAs. But it is becoming clear that RNA interference goes beyond these interactions. In their perspective, [Matzke and Matzke][1] discuss recent work ([Schramke and Allshire][2]) that shows that the silencing pathway can induce heterochromatin formation in DNA that is normally ...
Marjori, Matzke, Antonius J M, Matzke
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2011
Engineered "computing" biological networks are a generalization of endogenous regulatory pathways. They are intended to generate novel biological responses based on preprogrammed processing of multiple molecular signals. We have recently introduced an approach to constructing complex signal processing networks in mammalian cells using RNA interference (
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Engineered "computing" biological networks are a generalization of endogenous regulatory pathways. They are intended to generate novel biological responses based on preprogrammed processing of multiple molecular signals. We have recently introduced an approach to constructing complex signal processing networks in mammalian cells using RNA interference (
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Current Protocols in Bioinformatics, 2004
AbstractRNAi is a novel genetic tool that is poised to revolutionize the study of genetics and gene networks. Use of this tool requires knowledge of the underlying mechanisms and application of this knowledge to the construction of a gene‐silencing library. This unit discusses approaches to rational design of this library and its use in experiments. It
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AbstractRNAi is a novel genetic tool that is poised to revolutionize the study of genetics and gene networks. Use of this tool requires knowledge of the underlying mechanisms and application of this knowledge to the construction of a gene‐silencing library. This unit discusses approaches to rational design of this library and its use in experiments. It
openaire +2 more sources