Results 41 to 50 of about 323,847 (388)
Molecular Therapy, 2011 A recurring theme in the way that many pharmaceutical companies approach new technologies is that they are initially extremely enthusiastic, perhaps excessively so, but then subsequently overreact in the opposite direction, abandoning them when the first bumps in the road come along.
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Structural domains in RNAi [PDF]
FEBS Letters, 2005 Structural and biochemical studies have begun to elucidate the pathway of RNA silencing that leads to the formation of the RISC complex. The outstanding feature of this pathway is the precise recognition and processing of double‐stranded RNA. We present a review of recent structures that illustrate the molecular mechanisms contributing to these two ...
Robert E. Collins, Xiaodong Cheng
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Application of Exogenous dsRNAs-induced RNAi in Agriculture: Challenges and Triumphs
Frontiers in Plant Science, 2020 In recent years, RNA interference (RNAi) machinery has widely been explored by plant biologists for its potential applications in disease management, plant development, and germplasm improvement.
P. Das, S. Sherif
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The NS3 protein of rice hoja blanca virus suppresses RNA silencing in mammalian cells [PDF]
, 2008 The NS3 protein of the tenuivirus rice hoja blanca virus (RHBV) has previously been shown to represent the viral RNA interference (RNAi) suppressor and is active in both plant and insect cells by binding short interfering RNAs (siRNAs) in vitro.
Goldbach, R.W. +3 more
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Antiviral Applications of RNAi [PDF]
, 2006 RNA interference is a natural mechanism by which small interfering (si)RNA operates to specifically and potently down-regulate the expression of a target gene. This down-regulation has been thought to predominantly function at the level of the messenger (m)RNA, post-transcriptional gene silencing (PTGS). Recently, the discovery that siRNAs can function
John J. Rossi, Kevin V. Morris
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MicroRNAs that interfere with RNAi [PDF]
Worm, 2013 A recent study by Massirer et al. in the nematode C. elegans has shown that a family of microRNAs (miRNAs), miR-35-41, regulates the efficiency of RNA interference (RNAi), revealing a new connection between these small RNA pathways. In this commentary, we discuss the potential mechanisms for cross regulation in the miRNA and RNAi pathways and the ...
Katlin B. Massirer, Amy E. Pasquinelli
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Role of RNA Interference (RNAi) in the Moss Physcomitrella patens [PDF]
, 2013 RNA interference (RNAi) is a mechanism that regulates genes by either transcriptional (TGS) or posttranscriptional gene silencing (PTGS), required for genome maintenance and proper development of an organism.
Arif, Muhammad Asif +2 more
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GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics.
Nucleic Acid Therapeutics, 2018 Short-interfering RNA (siRNA)-induced RNAi responses have great potential to treat a wide variety of human diseases from cancer to pandemic viral outbreaks to Parkinson's Disease.
Aaron D. Springer, S. Dowdy
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Argonaute 2 Is Required for Extra-embryonic Endoderm Differentiation of Mouse Embryonic Stem Cells
Stem Cell Reports, 2018 Summary: In mouse, although four Argonaute (AGO) proteins with partly overlapping functions in small-RNA pathways exist, only Ago2 deficiency causes embryonic lethality.
Richard Patryk Ngondo +10 more
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Inhibition of cd46 receptor by rnai enhances cell resistance to bvdv infection [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2020 This study aimed to investigate the inhibition effect of CD46 on the replication of bovine viral diarrhea viruses (BVDV). BVDV causes bovine viral diarrheal mucosal disease, and prevention of BVDV infection is very important for livestock production ...
Ruirui HU +7 more
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