Results 41 to 50 of about 195,676 (344)

RNAi Mechanisms and Applications

BioTechniques, 2008
Within the past two decades we have become increasingly aware of the roles that RNAs play in regulation of gene expression. The RNA world was given a booster shot with the discovery of RNA interference (RNAi), a compendium of mechanisms involving small RNAs (less than 30 bases long) that regulate the expression of genes in a variety of eukaryotic ...
John J. Rossi, Daniel H. Kim
openaire   +3 more sources

Silencing of STAT3 via Peptidomimetic LNP-Mediated Systemic Delivery of RNAi Downregulates PD-L1 and Inhibits Melanoma Growth

Biomolecules, 2020
Cutaneous melanoma is the most aggressive skin cancer with notorious drug resistance. Inhibition of immune checkpoint molecules is one of the most promising approaches for cancer therapy.
Ehexige Ehexige, Mingming Bao, Purevbat Bazarjav, Xiang Yu, Hai Xiao, Shuqin Han, Huricha Baigude   +6 more
doaj   +1 more source

The Roles of DNA Methyltransferases 1 (DNMT1) in Regulating Sexual Dimorphism in the Cotton Mealybug, Phenacoccus solenopsis

Insects, 2020
The cotton mealybug, Phenacoccus solenopsis, is an invasive pest that can cause massive damage to many host plants of agricultural importance. P. solenopsis is highly polyphagous, and shows extreme sexual dimorphism between males and females.
Mohamed A.A. Omar, Meizhen Li, Feiling Liu, Kang He, Muhammad Qasim, Huamei Xiao, Mingxing Jiang, Fei Li   +7 more
doaj   +1 more source

Rekindling RNAi Therapy: Materials Design Requirements for In Vivo siRNA Delivery

Advances in Materials, 2019
With the recent FDA approval of the first siRNA‐derived therapeutic, RNA interference (RNAi)‐mediated gene therapy is undergoing a transition from research to the clinical space.
Byungji Kim, Ji-Ho Park, M. Sailor
semanticscholar   +1 more source

Improving RNAi efficiency for pest control in crop species

BioTechniques, 2020
The application of RNAi promotes the development of novel approaches toward plant protection in a sustainable way. Genetically modified crops expressing dsRNA have been developed as commercial products with great potential in insect pest management ...
Shuo Yan, Binyuan Ren, Bo Zeng, Jie Shen
semanticscholar   +1 more source

Quantitative Proteomics Identifies Metabolic Pathways Affected by Babesia Infection and Blood Feeding in the Sialoproteome of the Vector Rhipicephalus bursa

Vaccines, 2020
The negative impact of ticks and tick-borne diseases on animals and human health is driving research to discover novel targets affecting both vectors and pathogens.
Joana Couto, Margarita Villar, Lourdes Mateos-Hernández, Joana Ferrolho, Gustavo S. Sanches, Ana Sofia Santos, Maria Margarida Santos-Silva, João Nobre, Olga Moreira, Sandra Antunes, José de la Fuente, Ana Domingos   +11 more
doaj   +1 more source

Soaking up RNAi [PDF]

Molecular Cell, 2003
RNA interference (RNAi) describes the ability of double-stranded RNA (dsRNA) to inhibit homologous gene expression at the RNA or DNA level. In a recent paper, Feinberg and Hunter report that a single transmembrane dsRNA transport protein may enable RNAi to spread systemically from one cell to another.
openaire   +3 more sources

RNAi in Budding Yeast [PDF]

Science, 2009
Yeast Joins RNAi Club RNA interference (RNAi) silences gene expression via small interfering (si) RNAs that bind to target sequences. RNAi has been found in almost all eukaryotes examined, with the notable exception of the budding yeast, Saccharomyces cerevisiae , one of the most prominent organisms used ...
Drinnenberg, Ines A., Weinberg, David E., Xie, Kathleen Dongqin, Mower, Jeffrey P., Wolfe, Kenneth H., Bartel, David, Fink, Gerald R   +6 more
openaire   +4 more sources

Functional interplay between ribosomal protein paralogues in the eRpL22 family in Drosophila melanogaster

Fly, 2018
Duplicated ribosomal protein (RP) genes in the Drosophila melanogaster eRpL22 family encode structurally-divergent and differentially-expressed rRNA-binding RPs.
Catherine M. Mageeney, Michael G. Kearse, Brett W. Gershman, Caroline E. Pritchard, Jennifer M. Colquhoun, Vassie C. Ware   +5 more
doaj   +1 more source

Gold Nanoparticles in Conjunction with Nucleic Acids as a Modern Molecular System for Cellular Delivery

Molecules, 2020
Development of nanotechnology has become prominent in many fields, such as medicine, electronics, production of materials, and modern drugs. Nanomaterials and nanoparticles have gained recognition owing to the unique biochemical and physical properties ...
Anna Graczyk, Roza Pawlowska, Dominika Jedrzejczyk, Arkadiusz Chworos   +3 more
doaj   +1 more source