Results 71 to 80 of about 330,568 (380)
Parasite motility is critical for virulence of African trypanosomes. [PDF]
, 2018 African trypanosomes, Trypanosoma brucei spp., are lethal pathogens that cause substantial human suffering and limit economic development in some of the world's most impoverished regions.
Geng, Quanjie +6 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao +20 more
wiley +1 more source
Nature Methods, 2011 A recent study turns the creation of conditional short hairpin RNA transgenic mice into a rapid, flexible and scalable process.
openaire +2 more sources
Management of Pest Insects and Plant Diseases by Non-Transformative RNAi
Frontiers in Plant Science, 2019 Since the discovery of RNA interference (RNAi), scientists have made significant progress towards the development of this unique technology for crop protection.
Deise Cagliari +5 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji +7 more
wiley +1 more source
A Bayesian measurement error model for two-channel cell-based RNAi data with replicates
, 2012 RNA interference (RNAi) is an endogenous cellular process in which small double-stranded RNAs lead to the destruction of mRNAs with complementary nucleoside sequence. With the production of RNAi libraries, large-scale RNAi screening in human cells can be
Chang, I-Shou +8 more
core +1 more source
The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated, processed form of the apical caspase DRONC [PDF]
, 2002 Although loss of the inhibitor of apoptosis (LAP) protein DIAP1 has been shown to result in caspase activation and spontaneous cell death in Drosophila cells and embryos, the point at which DIAP1 normally functions to inhibit caspase activation is ...
Clem, Rollie J. +2 more
core +1 more source
Advanced Healthcare Materials, EarlyView.This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre +3 more
wiley +1 more source
Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells
Molecular & Cellular Oncology, 2019 A genome-wide small-interfering RNA-based screen identified the transcription factor Specificity Protein 3 (SP3) as a critical factor for Second mitochondrial-derived activator of caspase (Smac) mimetic-mediated killing of cancer cells.
Shawn T. Beug +2 more
doaj +1 more source
Biologia Plantarum, 2019 Sri Lankan cassava mosaic virus (SLCMV) is the principal causal agent of cassava mosaic disease in the Indian subcontinent. To gain resistance against the virus, the coat protein (CP) gene, namely the AV1 of SLCMV-Adivaram isolate, was cloned in either ...
A. GOGOI +4 more
doaj +1 more source