Results 191 to 200 of about 571,579 (318)

Editorial: The Quest for Biomarkers of Biological Age and Longevity Identifies Roles for Small Noncoding RNAs, Including PIWI-Interacting RNAs. [PDF]

Med Sci Monit
Parums DV.
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Synthetic short RNA in cancer. [PDF]

Front Oncol
Tomita T, Minagawa K, Hiratsuka S.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Testicular origin of epigenetic inheritance independent of sperm mitochondrial DNA and epididymal exposure. [PDF]

Proc Natl Acad Sci U S A
Wang Z, Yamauchi Y, Chen S, Zheng H, Ward MA, Yan W.   +5 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Noncoding RNAs as potential biomarkers to predict the outcome in pancreatic cancer

, 2015
Kaizhou Jin,1–3,* Guopei Luo,1–3,* Zhiwen Xiao,1–3 Zuqiang Liu,1–3 Chen Liu,1–3 Shunrong Ji,1–3 Jin Xu,1–3 Liang Liu,1–3 Jiang Long,1–3 Quanxing Ni,1–3 Xianjun Yu1–3 1Department of ...
Ji S, Liu Z, Liu L, Xiao Z, Long J, Luo G, Ni Q, Liu C, Jin K, Xu J, Yu X   +10 more
core  

The RNA exosome: mechanisms of RNA surveillance, regulation, and disease. [PDF]

RNA Biol
Upadhyai P, Quadri N, Chandran D.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

siRNAs, tRNAs, and rRNAs in Osteoarthritis: Biological Functions and Therapeutic Opportunities

Biologics: Targets & Therapy
Mina Wang,1,* Yidan Dai,1,* Xiaobo Ge,1,* Libin Zheng,1,2 Miaoxin Zhai,3 Wenshan Li,1,2 Guannan Liu,1 Xiaoyu Cheng,1 Jiangyan Wei,1 Xin Yang,1 Lu Liu,1 Huilin Liu,1 Jingqing Sun,1 Bin Li,1 Fang Yuan1 1Department of Acupuncture and
Wang M, Dai Y, Ge X, Zheng L, Zhai M, Li W, Liu G, Cheng X, Wei J, Yang X, Liu L, Liu H, Sun J, Li B, Yuan F   +14 more
doaj