Results 61 to 70 of about 1,043,746 (362)

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Comparative Analysis of RNA Families Reveals Distinct Repertoires for Each Domain of Life [PDF]

PLoS Comput Biol. 2012 8(11):e1002752, 2012
The RNA world hypothesis, that RNA genomes and catalysts preceded DNA genomes and genetically-encoded protein catalysts, has been central to models for the early evolution of life on Earth. A key part of such models is continuity between the earliest stages in the evolution of life and the RNA repertoires of extant lineages.
arxiv   +1 more source

LINC01089 governs the miR-1287-5p/HSPA4 axis to negatively regulate osteogenic differentiation of mesenchymal stem cells

Bone & Joint Research
Aims: The involvement of long non-coding RNA (lncRNA) in bone marrow mesenchymal stem cell (MSC) osteogenic differentiation during osteoporosis (OP) development has attracted much attention. In this study, we aimed to disclose how LINC01089 functions in
Hao Zou, Fei Hu, Xin Wu, Bin Xu, Guifeng Shang, Dong An, Dehao Qin, Xiaolei Zhang, Aofei Yang   +8 more
doaj   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Genome-Wide Profiling of Circular RNAs in the Rapidly Growing Shoots of Moso Bamboo (Phyllostachys edulis). [PDF]

, 2019
Circular RNAs, including circular exonic RNAs (circRNA), circular intronic RNAs (ciRNA) and exon-intron circRNAs (EIciRNAs), are a new type of noncoding RNAs.
Gao, Yubang, Gu, Lianfeng, Hu, Kaiqiang, Kohnen, Markus V, Lin, Chentao, Liu, Xuqing, Wang, Huihui, Wang, Huiyuan, Wang, Yongsheng, Xi, Feihu, Xu, Xi, Zhang, Hangxiao, Zhang, Zeyu, Zhao, Liangzhen   +13 more
core  

T-ALL and thymocytes : a message of noncoding RNAs [PDF]

, 2017
In the last decade, the role for noncoding RNAs in disease was clearly established, starting with microRNAs and later expanded towards long noncoding RNAs.
Durinck, Kaat, Speleman, Franki, Taghon, Tom, Van Vlierberghe, Pieter, Wallaert, Annelynn   +4 more
core   +3 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Mapping RNA–RNA interactome and RNA structure in vivo by MARIO [PDF]

Nature Communications, 2016
AbstractThe pervasive transcription of our genome presents a possibility of revealing new genomic functions by investigating RNA interactions. Current methods for mapping RNA–RNA interactions have to rely on an ‘anchor’ protein or RNA and often require molecular perturbations.
Nguyen, Tri C, Cao, Xiaoyi, Yu, Pengfei, Xiao, Shu, Lu, Jia, Biase, Fernando H, Sridhar, Bharat, Huang, Norman, Zhang, Kang, Zhong, Sheng   +9 more
openaire   +5 more sources

Transfer RNA and Origins of RNA Interference [PDF]

Frontiers in Molecular Biosciences, 2021
Almost 30 years ago the first microRNA (miRNA) was detected (Lee et al., 1993), later put in mechanistical context by the discovery of the RNA interference (RNAi) and RNA-induced silencing complex (RISC). miRNA is the variable RISC element (guide) that recognizes messenger RNA (mRNA) targets in the RNAi process facilitated by Argonaute (Ago) proteins ...
openaire   +5 more sources

Interpretable RNA Foundation Model from Unannotated Data for Highly Accurate RNA Structure and Function Predictions [PDF]

arXiv, 2022
Non-coding RNA structure and function are essential to understanding various biological processes, such as cell signaling, gene expression, and post-transcriptional regulations. These are all among the core problems in the RNA field. With the rapid growth of sequencing technology, we have accumulated a massive amount of unannotated RNA sequences.
arxiv