Results 41 to 50 of about 495,103 (267)

Comparisons of miRNA profiles of exosomes derived from human iPSCs, ADSCs, and BMSCs and effects on chondrocyte function

Bone & Joint Research
Aims: This study aimed to identify and compare the microRNA (miRNA) profiles of exosomes derived from human induced pluripotent stem cells (iPSCs), bone marrow mesenchymal stem cells (BMSCs), and adipose tissue-derived stem cells (ADSCs) (hiPSC-Exos ...
Ling-Hua Chang, Shu-Chun Chuang, Shun-Cheng Wu, Yin-Chih Fu, Jhen-Wei Chen, Che-Wei Wu, Yi-Shan Lin, Cyong-Yue Liu, Yu-Hsuan Chung, Je-Ken Chang, Chung-Hwan Chen, Mei-Ling Ho   +11 more
doaj   +1 more source

Non-Coding RNAs and SARS-Related Coronaviruses

Viruses, 2020
The emergence of SARS-CoV-2 in 2019 has caused a major health and economic crisis around the globe. Gaining knowledge about its attributes and interactions with human host cells is crucial.
Hanna Henzinger, Dominik A. Barth, Christiane Klec, Martin Pichler   +3 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

RNA modification of an RNA modifier prevents self-RNA sensing

PLOS Biology, 2021
A new study in PLOS Biology finds that interferon (IFN)-induced adenosine deaminase acting on RNA 1 (ADAR1) mRNA is N6-methyladenosine (m6A) modified to promote its translation, enabling ADAR1 to modify self-double-stranded RNAs (dsRNAs) generated during the IFN response and preventing activation of the melanoma differentiation-associated protein 5 ...
Daltry L. Snider, Stacy M. Horner
openaire   +4 more sources

Diagnostic biomarkers for non-traumatic osteonecrosis of the femoral head: a systematic review and pathophysiological cascade network

Bone & Joint Research
Aims: Many studies have focused on identifying specific biomarkers for the early diagnosis of non-traumatic osteonecrosis of the femoral head (NONFH).
Yawei Dong, Jigao Sun, Shuwen Li, Jiawen Zhang, Yan Yan, Taixian Li, Yan Jia   +6 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Matrin3 regulates mitotic spindle dynamics by controlling alternative splicing of CDC14B

Cell Reports, 2023
Summary: Matrin3 is an RNA-binding protein that regulates diverse RNA-related processes, including mRNA splicing. Although Matrin3 has been intensively studied in neurodegenerative diseases, its function in cancer remains unclear. Here, we report Matrin3-
Bruna R. Muys, Roshan L. Shrestha, Dimitrios G. Anastasakis, Lorinc Pongor, Xiao Ling Li, Ioannis Grammatikakis, Ahsan Polash, Raj Chari, Myriam Gorospe, Curtis C. Harris, Mirit I. Aladjem, Munira A. Basrai, Markus Hafner, Ashish Lal   +13 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA [PDF]

Nature, 2009
Constitutive expression of telomerase in human cells prevents the onset of senescence and crisis by maintaining telomere homeostasis. However, accumulating evidence suggests that the human telomerase reverse transcriptase catalytic subunit (TERT) contributes to cell physiology independently of its ability to elongate telomeres.
Maida, Yoshiko, Yasukawa, Mami, Furuuchi, Miho, Lassmann, Timo, Possemato, Richard, Okamoto, Naoko, Kasim, Vivi, Hayashizaki, Yoshihide, Hahn, William C., Masutomi, Kenkichi   +9 more
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source