Results 41 to 50 of about 1,710,125 (310)

Small non-coding RNAs: Diagnostic and therapeutic news [PDF]

Journal of Medical Biochemistry, 2008
Non-coding RNAs represent a specific type of RNAs that are non translated into proteins. They participate in a number of different regulatory processes concerning the transcriptional and posttranscriptional level.
Kocić Gordana
doaj  

Involvement of Long Non-Coding RNAs (lncRNAs) in Tumor Angiogenesis

Non-Coding RNA, 2020
Long non-coding RNAs (lncRNAs) are defined as non-protein coding transcripts with a minimal length of 200 nucleotides. They are involved in various biological processes such as cell differentiation, apoptosis, as well as in pathophysiological processes ...
Julia Teppan, Dominik A. Barth, Felix Prinz, Katharina Jonas, Martin Pichler, Christiane Klec   +5 more
doaj   +1 more source

Molecular mechanisms of long noncoding RNAs

Molecules and Cells, 2011
Summary Long noncoding RNAs (lncRNAs) are an important class of pervasive genes involved in a variety of biological functions. Here we discuss the emerging archetypes of molecular functions that lncRNAs execute—as signals, decoys, guides, and scaffolds ...
Kevin C. Wang, Howard Y. Chang
semanticscholar   +1 more source

Long-Noncoding RNA (lncRNA) in the Regulation of Hypoxia-Inducible Factor (HIF) in Cancer

Non-Coding RNA, 2020
Hypoxia is dangerous for oxygen-dependent cells, therefore, physiological adaption to cellular hypoxic conditions is essential. The transcription factor hypoxia-inducible factor (HIF) is the main regulator of hypoxic metabolic adaption reducing oxygen ...
Dominik A. Barth, Felix Prinz, Julia Teppan, Katharina Jonas, Christiane Klec, Martin Pichler   +5 more
doaj   +1 more source

Employing single-cell RNA sequencing coupled with an array of bioinformatics approaches to ascertain the shared genetic characteristics between osteoporosis and obesity

Bone & Joint Research
Aims: This study examined the relationship between obesity (OB) and osteoporosis (OP), aiming to identify shared genetic markers and molecular mechanisms to facilitate the development of therapies that target both conditions simultaneously.
Dingzhuo Liu, Fangming Cao, Dian Liu, Hao Li, Lin Tao, Yue Zhu   +5 more
doaj   +1 more source

RNA interference is mediated by 21- and 22-nucleotide RNAs.

Genes & Development, 2001
Double-stranded RNA (dsRNA) induces sequence-specific posttranscriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we demonstrate that 21- and 22-nt RNA fragments are the sequence-
Sayda M. Elbashir, Winfried Lendeckel, T. Tuschl   +2 more
semanticscholar   +1 more source

Biogenesis and Regulatory Roles of Circular RNAs

Annual Review of Cell and Developmental Biology, 2022
Covalently closed, single-stranded circular RNAs can be produced from viral RNA genomes as well as from the processing of cellular housekeeping noncoding RNAs and precursor messenger RNAs.
Li Yang, J. Wilusz, Ling-Ling Chen
semanticscholar   +1 more source

Exploring the interactome of the Staphylococcus aureus sRNA Srn_9342 identified a complex formation with RNAIII leading to the modulation of δ-hemolysin expression

BMC Microbiology
Background Staphylococcus aureus is a major pathogen responsible for a variety of infections. It expresses a wide range of factors to precisely coordinate gene expression in response to the ever-changing conditions.
Julie Bronsard, Chloé Silard, Julie Legros, Noëlla Germain-Amiot, Marc Hallier, Yoann Augagneur   +5 more
doaj   +1 more source

Comparisons of miRNA profiles of exosomes derived from human iPSCs, ADSCs, and BMSCs and effects on chondrocyte function

Bone & Joint Research
Aims: This study aimed to identify and compare the microRNA (miRNA) profiles of exosomes derived from human induced pluripotent stem cells (iPSCs), bone marrow mesenchymal stem cells (BMSCs), and adipose tissue-derived stem cells (ADSCs) (hiPSC-Exos ...
Ling-Hua Chang, Shu-Chun Chuang, Shun-Cheng Wu, Yin-Chih Fu, Jhen-Wei Chen, Che-Wei Wu, Yi-Shan Lin, Cyong-Yue Liu, Yu-Hsuan Chung, Je-Ken Chang, Chung-Hwan Chen, Mei-Ling Ho   +11 more
doaj   +1 more source

Cup‐Like Nuclei Is a Hallmark of DUX4/ERG Acute Lymphoblastic Leukemia and Reveals Cytoplasmic Mitochondria Accumulation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille, Hugo Roux, Odile Fenneteau, Aurélie Caye‐Eude, Alexia Kinoo, Yoann Vial, André Baruchel, Marion Strullu, Elodie Lainey, Hélène Cavé   +9 more
wiley   +1 more source