Results 41 to 50 of about 571,579 (318)
RNA as Multitude/RNA as One [PDF]
Chemistry & Biology, 2003 In the configurations formed by RNA and its ions there are structural possibilities not yet realized; some are hinted at in new work on the binding of an amino acid analog.
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Targeted knock-down of miR21 primary transcripts using snoMEN vectors induces apoptosis in human cancer cell lines [PDF]
, 2015 We have previously reported an antisense technology, ‘snoMEN vectors’, for targeted knock-down of protein coding mRNAs using human snoRNAs manipulated to contain short regions of sequence complementarity with the mRNA target. Here we characterise the use
Bensaddek, Dalila +23 more
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Long-Noncoding RNA (lncRNA) in the Regulation of Hypoxia-Inducible Factor (HIF) in Cancer
Non-Coding RNA, 2020 Hypoxia is dangerous for oxygen-dependent cells, therefore, physiological adaption to cellular hypoxic conditions is essential. The transcription factor hypoxia-inducible factor (HIF) is the main regulator of hypoxic metabolic adaption reducing oxygen ...
Dominik A. Barth +5 more
doaj +1 more source
Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA
Journal of Visualized Experiments, 2021 The growing role attributed nowadays to long non-coding RNAs (lncRNA) in physiology and pathophysiology makes it crucial to characterize their interactome by identifying their molecular partners, DNA, proteins and/or RNAs. The latter can interact with lncRNA through networks involving proteins, but they can also be engaged in direct RNA/RNA ...
Jacq, Audrey +6 more
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Role of RNA Interference (RNAi) in the Moss Physcomitrella patens [PDF]
, 2013 RNA interference (RNAi) is a mechanism that regulates genes by either transcriptional (TGS) or posttranscriptional gene silencing (PTGS), required for genome maintenance and proper development of an organism.
Arif, M. +8 more
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BMC MicrobiologyBackground Staphylococcus aureus is a major pathogen responsible for a variety of infections. It expresses a wide range of factors to precisely coordinate gene expression in response to the ever-changing conditions.
Julie Bronsard +5 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke +4 more
wiley +1 more source
Small Nucleolar RNAs: Identification, Structure, and Function
, 2006 The revelation in the last few years of a large number of new noncoding RNAs (ncRNAs) has revolutionized our view of how gene regulation works. This is to a large extent due to the recent advances in computational as well as experimental methodology ...
Söderbom, Fredrik,, Fredrik Söderbom
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RNA modification of an RNA modifier prevents self-RNA sensing
PLOS Biology, 2021 A new study in PLOS Biology finds that interferon (IFN)-induced adenosine deaminase acting on RNA 1 (ADAR1) mRNA is N6-methyladenosine (m6A) modified to promote its translation, enabling ADAR1 to modify self-double-stranded RNAs (dsRNAs) generated during the IFN response and preventing activation of the melanoma differentiation-associated protein 5 ...
Daltry L. Snider, Stacy M. Horner
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FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source