Results 21 to 30 of about 1,710,125 (310)
Bacterial Type I Toxins: Folding and Membrane Interactions
Toxins, 2021 Bacterial type I toxin-antitoxin systems are two-component genetic modules that encode a stable toxic protein whose ectopic overexpression can lead to growth arrest or cell death, and an unstable RNA antitoxin that inhibits toxin translation during ...
Sylvie Nonin-Lecomte +3 more
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Frequency of RNA–RNA interaction in a model of the RNA World [PDF]
RNA, 2006 The RNA World model for prebiotic evolution posits the selection of catalytic/template RNAs from random populations. The mechanisms by which these random populations could be generated de novo are unclear. Non-enzymatic and RNA-catalyzed nucleic acid polymerizations are poorly processive, which means that the resulting short-chain RNA population could ...
John C, Striggles +2 more
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Functional classification and experimental dissection of long noncoding RNAs
Cell, 2018 Over the last decade, it has been increasingly demonstrated that the genomes of many species are pervasively transcribed, resulting in the production of numerous long noncoding RNAs (lncRNAs).
F. Kopp, J. Mendell
semanticscholar +1 more source
Microorganisms, 2021 Growing evidence indicates that small noncoding RNAs (sRNAs) play important regulatory roles during bacterial infection. In Salmonella Typhimurium, several sRNAs are strongly up-regulated within macrophages, but little is known about their role during ...
Diego Peñaloza +7 more
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Genome Research, 2012 The human genome contains many thousands of long noncoding RNAs (lncRNAs). While several studies have demonstrated compelling biological and disease roles for individual examples, analytical and experimental approaches to investigate these genes have ...
T. Derrien +26 more
semanticscholar +1 more source
Circular RNAs: Characterization, cellular roles, and applications.
Cell, 2022 Most circular RNAs are produced from the back-splicing of exons of precursor mRNAs. Recent technological advances have in part overcome problems with their circular conformation and sequence overlap with linear cognate mRNAs, allowing a better ...
Chu-Xiao Liu, Ling-Ling Chen
semanticscholar +1 more source
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.
Cell, 1993 lin-4 is essential for the normal temporal control of diverse postembryonic developmental events in C. elegans. lin-4 acts by negatively regulating the level of LIN-14 protein, creating a temporal decrease in LIN-14 protein starting in the first larval ...
Rosalind C. Lee +2 more
semanticscholar +1 more source
Single-photon microscopy to study biomolecular condensates
Nature Communications, 2023 Biomolecular condensates serve as membrane-less compartments within cells, concentrating proteins and nucleic acids to facilitate precise spatial and temporal orchestration of various biological processes.
Eleonora Perego +10 more
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RNA-Catalyzed RNA Ligation on an External RNA Template [PDF]
Chemistry & Biology, 2002 Variants of the hc ligase ribozyme, which catalyzes ligation of the 3' end of an RNA substrate to the 5' end of the ribozyme, were utilized to evolve a ribozyme that catalyzes ligation reactions on an external RNA template. The evolved ribozyme catalyzes the joining of an oligonucleotide 3'-hydroxyl to the 5'-triphosphate of an RNA hairpin molecule ...
McGinness, Kathleen E, Joyce, Gerald F
openaire +2 more sources
Frontiers in Cellular and Infection Microbiology, 2021 Small regulatory RNAs (sRNAs) are key players in bacterial regulatory networks. Monitoring their expression inside living colonized or infected organisms is essential for identifying sRNA functions, but few studies have looked at sRNA expression during ...
Guillaume Ménard +5 more
doaj +1 more source