Results 21 to 30 of about 571,579 (318)
Frequency of RNA–RNA interaction in a model of the RNA World [PDF]
RNA, 2006 The RNA World model for prebiotic evolution posits the selection of catalytic/template RNAs from random populations. The mechanisms by which these random populations could be generated de novo are unclear. Non-enzymatic and RNA-catalyzed nucleic acid polymerizations are poorly processive, which means that the resulting short-chain RNA population could ...
John C, Striggles +2 more
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Microorganisms, 2021 Growing evidence indicates that small noncoding RNAs (sRNAs) play important regulatory roles during bacterial infection. In Salmonella Typhimurium, several sRNAs are strongly up-regulated within macrophages, but little is known about their role during ...
Diego Peñaloza +7 more
doaj +1 more source
Cooperativity and Interdependency between RNA Structure and RNA–RNA Interactions [PDF]
Non-Coding RNA, 2021 Complex RNA–RNA interactions are increasingly known to play key roles in numerous biological processes from gene expression control to ribonucleoprotein granule formation. By contrast, the nature of these interactions and characteristics of their interfaces, especially those that involve partially or wholly structured RNAs, remain elusive.
Ilias Skeparnias, Jinwei Zhang
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RNA-Catalyzed RNA Ligation on an External RNA Template [PDF]
Chemistry & Biology, 2002 Variants of the hc ligase ribozyme, which catalyzes ligation of the 3' end of an RNA substrate to the 5' end of the ribozyme, were utilized to evolve a ribozyme that catalyzes ligation reactions on an external RNA template. The evolved ribozyme catalyzes the joining of an oligonucleotide 3'-hydroxyl to the 5'-triphosphate of an RNA hairpin molecule ...
McGinness, Kathleen E, Joyce, Gerald F
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Topology of RNA-RNA Interaction Structures [PDF]
Journal of Computational Biology, 2012 40 pages 15 ...
Jørgen E. Andersen +3 more
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Computational analysis of next generation sequencing data : from transcription start sites in bacteria to human non-coding RNAS [PDF]
, 2014 The advent of next generation sequencing (NGS) technologies has revolutionized the field of molecular biology by providing a wealth of sequence data. “Transcriptomics”, which aims to identify and annotate the complete set of RNA molecules transcribed ...
Jorjani, Hadi
core +1 more source
Single-photon microscopy to study biomolecular condensates
Nature Communications, 2023 Biomolecular condensates serve as membrane-less compartments within cells, concentrating proteins and nucleic acids to facilitate precise spatial and temporal orchestration of various biological processes.
Eleonora Perego +10 more
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CHIMIA, 2019 Advances in the chemical synthesis of RNA have opened new possibilities to address current questions in RNA biology. Access to site-specifically modified oligoribonucleotides is often a pre-requisite for RNA chemical-biology projects. Driven by the enormous research efforts for development of oligonucleotide therapeutics, a wide range of ...
Rothlisberger, Pascal +2 more
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Fast prediction of RNA-RNA interaction [PDF]
Algorithms for Molecular Biology, 2009 Abstract Background Regulatory antisense RNAs are a class of ncRNAs that regulate gene expression by prohibiting the translation of an mRNA by establishing stable interactions with a target sequence. There is great demand for efficient computational methods to predict the specific interaction between an ncRNA and its ...
Salari, Raheleh +2 more
openaire +6 more sources
Frontiers in Cellular and Infection Microbiology, 2021 Small regulatory RNAs (sRNAs) are key players in bacterial regulatory networks. Monitoring their expression inside living colonized or infected organisms is essential for identifying sRNA functions, but few studies have looked at sRNA expression during ...
Guillaume Ménard +5 more
doaj +1 more source