Results 1 to 10 of about 1,710,125 (310)
Long non-coding RNAs: definitions, functions, challenges and recommendations
Nature Reviews Molecular Cell Biology, 2023 Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes of complex organisms. The term ‘lncRNAs’ encompasses RNA polymerase I (Pol I), Pol II and Pol III transcribed RNAs, and RNAs from processed introns.
Chandrasekhar Kanduri +2 more
exaly +2 more sources
Gene regulation by long non-coding RNAs and its biological functions
Nature Reviews Molecular Cell Biology, 2020 Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs) are widely expressed and have key roles in gene regulation. Recent studies have begun to unravel how the biogenesis of lncRNAs is distinct from that of mRNAs and is ...
Luisa Statello +2 more
exaly +2 more sources
Bone & Joint Research, 2021 Aims: Circular RNAs (circRNAs) are a novel type of non-coding RNA that plays major roles in the development of diverse diseases including osteonecrosis of the femoral head (ONFH). Here, we explored the impact of hsa_circ_0066523 derived from forkhead box
Wei Xin +4 more
doaj +1 more source
Bone & Joint Research, 2023 Aims: To explore the novel molecular mechanisms of histone deacetylase 4 (HDAC4) in chondrocytes via RNA sequencing (RNA-seq) analysis. Methods: Empty adenovirus (EP) and a HDAC4 overexpression adenovirus were transfected into cultured human chondrocytes.
Li Guo +9 more
doaj +1 more source
LncRNA PCBP1-AS1 induces osteoporosis by sponging miR-126-5p/PAK2 axis
Bone & Joint Research, 2023 Aims: Long non-coding RNAs (lncRNAs) act as crucial regulators in osteoporosis (OP). Nonetheless, the effects and potential molecular mechanism of lncRNA PCBP1 Antisense RNA 1 (PCBP1-AS1) on OP remain largely unclear. The aim of this study was to explore
Zhihui Li
doaj +1 more source
Triggering of RNA Interference with RNA–RNA, RNA–DNA, and DNA–RNA Nanoparticles [PDF]
ACS Nano, 2014 Control over cellular delivery of different functionalities and their synchronized activation is a challenging task. We report several RNA and RNA/DNA-based nanoparticles designed to conditionally activate the RNA interference in various human cells.
Afonin, Kirill A. +10 more
openaire +2 more sources
Thermodynamics of RNA–RNA binding [PDF]
Bioinformatics, 2006 Abstract Background: Reliable prediction of RNA–RNA binding energies is crucial, e.g. for the understanding on RNAi, microRNA–mRNA binding and antisense interactions. The thermodynamics of such RNA–RNA interactions can be understood as the sum of two energy contributions: (1) the energy necessary to ‘open’ the binding site and (2) the ...
Ulrike Mückstein +5 more
openaire +4 more sources
RNA Chaperones, RNA Annealers and RNA Helicases [PDF]
RNA Biology, 2007 RNA molecules face difficulties when folding into their native structures. In the cell, proteins can assist RNAs in reaching their functionally active states by binding and stabilizing a specific structure or, in a quite opposite way, by interacting in a non-specific manner. These proteins can either facilitate RNA-RNA interactions in a reaction termed
Rajkowitsch, Lukas +9 more
openaire +3 more sources
Combinatorics of RNA–RNA interaction [PDF]
Journal of Mathematical Biology, 2011 RNA-RNA binding is an important phenomenon observed for many classes of non-coding RNAs and plays a crucial role in a number of regulatory processes. Recently several MFE folding algorithms for predicting the joint structure of two interacting RNA molecules have been proposed.
Li, Thomas J X, Reidys, Christian
openaire +5 more sources
mSystems, 2022 Staphylococcus aureus is a major human and animal pathogen, colonizing diverse ecological niches within its hosts. Predicting whether an isolate will infect a specific host and its subsequent clinical fate remains unknown.
Mohamed Sassi +8 more
doaj +1 more source