Results 1 to 10 of about 571,579 (318)
Bone & Joint Research, 2021 Aims: Circular RNAs (circRNAs) are a novel type of non-coding RNA that plays major roles in the development of diverse diseases including osteonecrosis of the femoral head (ONFH). Here, we explored the impact of hsa_circ_0066523 derived from forkhead box
Wei Xin +4 more
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Bone & Joint Research, 2023 Aims: To explore the novel molecular mechanisms of histone deacetylase 4 (HDAC4) in chondrocytes via RNA sequencing (RNA-seq) analysis. Methods: Empty adenovirus (EP) and a HDAC4 overexpression adenovirus were transfected into cultured human chondrocytes.
Li Guo +9 more
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LncRNA PCBP1-AS1 induces osteoporosis by sponging miR-126-5p/PAK2 axis
Bone & Joint Research, 2023 Aims: Long non-coding RNAs (lncRNAs) act as crucial regulators in osteoporosis (OP). Nonetheless, the effects and potential molecular mechanism of lncRNA PCBP1 Antisense RNA 1 (PCBP1-AS1) on OP remain largely unclear. The aim of this study was to explore
Zhihui Li
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Investigation of molecular regulation mechanism under the pathophysiology of subarachnoid hemorrhage
Open Life Sciences, 2021 This study aimed to investigate the molecular mechanism under the pathophysiology of subarachnoid hemorrhage (SAH) and identify the potential biomarkers for predicting the risk of SAH.
Weng Yifei
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mSystems, 2022 Staphylococcus aureus is a major human and animal pathogen, colonizing diverse ecological niches within its hosts. Predicting whether an isolate will infect a specific host and its subsequent clinical fate remains unknown.
Mohamed Sassi +8 more
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BRD4 promotes heterotopic ossification through upregulation of LncRNA MANCR
Bone & Joint Research, 2021 Aims: Acquired heterotopic ossification (HO) is a debilitating disease characterized by abnormal extraskeletal bone formation within soft-tissues after injury. The exact pathogenesis of HO remains unknown.
Lei Liu +9 more
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Expanding the Staphylococcus aureus SarA Regulon to Small RNAs
mSystems, 2021 SarA, a transcriptional regulator of Staphylococcus aureus, is a major global regulatory system that coordinates the expression of target genes involved in its pathogenicity.
Charlotte Oriol +7 more
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Bone & Joint Research, 2023 Aims: Osteoporosis (OP) is a metabolic bone disease, characterized by a decrease in bone mineral density (BMD). However, the research of regulatory variants has been limited for BMD.
Yumeng Jia +7 more
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Galleria mellonella as a Suitable Model of Bacterial Infection: Past, Present and Future
Frontiers in Cellular and Infection Microbiology, 2021 The increasing interest for Galleria mellonella larvae as an infection model is evidenced by the number of papers reporting its use, which increases exponentially since the early 2010s.
Guillaume Ménard +3 more
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METTL16 in human diseases: What should we do next?
Open Medicine, 2023 METTL16 is a class-I methyltransferase that is responsible for depositing a vertebrate-conserved S-adenosylmethionine site. Since 2017, there has been a growing body of research focused on METTL16, particularly in the field of structural studies. However,
Zhang Hui +4 more
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