Results 11 to 20 of about 1,710,125 (310)

Investigation of molecular regulation mechanism under the pathophysiology of subarachnoid hemorrhage

Open Life Sciences, 2021
This study aimed to investigate the molecular mechanism under the pathophysiology of subarachnoid hemorrhage (SAH) and identify the potential biomarkers for predicting the risk of SAH.
Weng Yifei
doaj   +1 more source

BRD4 promotes heterotopic ossification through upregulation of LncRNA MANCR

Bone & Joint Research, 2021
Aims: Acquired heterotopic ossification (HO) is a debilitating disease characterized by abnormal extraskeletal bone formation within soft-tissues after injury. The exact pathogenesis of HO remains unknown.
Lei Liu, ZiHao Li, Siwen Chen, Haowen Cui, Xiang Li, Guo Dai, Fangling Zhong, Wenjun Hao, Kuibo Zhang, Hui Liu   +9 more
doaj   +1 more source

Expanding the Staphylococcus aureus SarA Regulon to Small RNAs

mSystems, 2021
SarA, a transcriptional regulator of Staphylococcus aureus, is a major global regulatory system that coordinates the expression of target genes involved in its pathogenicity.
Charlotte Oriol, Liviu Cengher, Adhar C. Manna, Tony Mauro, Marie-Laure Pinel-Marie, Brice Felden, Ambrose Cheung, Astrid Rouillon   +7 more
doaj   +3 more sources

Integrating genome-wide association study with regulatory SNP annotations identified novel candidate genes for osteoporosis

Bone & Joint Research, 2023
Aims: Osteoporosis (OP) is a metabolic bone disease, characterized by a decrease in bone mineral density (BMD). However, the research of regulatory variants has been limited for BMD.
Yumeng Jia, Xin Qi, Mei Ma, Shiqiang Cheng, Bolun Cheng, Chujun Liang, Xiong Guo, Feng Zhang   +7 more
doaj   +1 more source

Galleria mellonella as a Suitable Model of Bacterial Infection: Past, Present and Future

Frontiers in Cellular and Infection Microbiology, 2021
The increasing interest for Galleria mellonella larvae as an infection model is evidenced by the number of papers reporting its use, which increases exponentially since the early 2010s.
Guillaume Ménard, Astrid Rouillon, Vincent Cattoir, Pierre-Yves Donnio   +3 more
doaj   +1 more source

Nanocircular RNAs for RNA interference [PDF]

Nucleic Acids Symposium Series, 2008
We designed and synthesized dumbbell-shaped nanocircular RNAs for RNA interference applications, which consist of a stem and two loops(1). RNA dumbbells are specifically recognized and cleaved by the human Dicer enzyme, and are thus transformed into double-stranded RNA in cells, although this RNA is resistant to degradation in serum.
Hiroshi, Abe, Naoko, Abe, Mitsuru, Harada, Satoshi, Tsuneda, Yoshihiro, Ito   +4 more
openaire   +2 more sources

METTL16 in human diseases: What should we do next?

Open Medicine, 2023
METTL16 is a class-I methyltransferase that is responsible for depositing a vertebrate-conserved S-adenosylmethionine site. Since 2017, there has been a growing body of research focused on METTL16, particularly in the field of structural studies. However,
Zhang Hui, Yin Mengqi, Huang Hua, Zhao Gongfang, Lu Mingliang   +4 more
doaj   +1 more source

RNA helicases in RNA decay [PDF]

Biochemical Society Transactions, 2018
RNA molecules have the tendency to fold into complex structures or to associate with complementary RNAs that exoribonucleases have difficulties processing or degrading. Therefore, degradosomes in bacteria and organelles as well as exosomes in eukaryotes have teamed-up with RNA helicases.
Khemici, Vanessa, Linder, Patrick
openaire   +5 more sources

PIWI-interacting RNAs: small RNAs with big functions

Nature Reviews Genetics, 2018
Ozata Dm, Phillip D Zamore, Donal O'Carroll   +2 more
exaly   +2 more sources

Correction: Nonin-Lecomte et al. Bacterial Type I Toxins: Folding and Membrane Interactions. Toxins 2021, 13, 490

Toxins, 2021
The authors wish to make the following corrections to their paper [...]
Sylvie Nonin-Lecomte, Laurence Fermon, Brice Felden, Marie-Laure Pinel-Marie   +3 more
doaj   +1 more source