Results 61 to 70 of about 495,103 (267)

Mapping RNA–RNA interactome and RNA structure in vivo by MARIO [PDF]

Nature Communications, 2016
Abstract The pervasive transcription of our genome presents a possibility of revealing new genomic functions by investigating RNA interactions. Current methods for mapping RNA–RNA interactions have to rely on an ‘anchor’ protein or RNA and often require molecular perturbations. Here we present the MARIO (
Nguyen, Tri C, Cao, Xiaoyi, Yu, Pengfei, Xiao, Shu, Lu, Jia, Biase, Fernando H, Sridhar, Bharat, Huang, Norman, Zhang, Kang, Zhong, Sheng   +9 more
openaire   +5 more sources

Regulatory RNA Ern0160 controls Enterococcus faecium virulence through direct modulation of expression of LysM domain-containing proteins

BMC Genomics
Background Enterococcus faecium is a commensal of the human gut microbiota that can become an opportunistic pathogen, particularly in immunocompromised individuals.
Loren Dejoies, Valérie Bordeau, Killian Le Neindre, Sophie Reissier, Kevin Arnould, Brice Felden, Svetlana Chabelskaya, François Guérin, Charlotte Michaux, Vincent Cattoir   +9 more
doaj   +1 more source

Transcriptomic analyses and machine-learning methods reveal dysregulated key genes and potential pathogenesis in human osteoarthritic cartilage

Bone & Joint Research
Aims: This study aimed to explore the biological and clinical importance of dysregulated key genes in osteoarthritis (OA) patients at the cartilage level to find potential biomarkers and targets for diagnosing and treating OA. Methods: Six sets of gene
Di Zhao, Ling-feng Zeng, Gui-hong Liang, Ming-hui Luo, Jian-ke Pan, Yao-xing Dou, Fang-zheng Lin, He-tao Huang, Wei-yi Yang, Jun Liu   +9 more
doaj   +1 more source

Pseudogenes, RNAs and new reproducibility norms

eLife, 2020
The partial success of a study to reproduce experiments that linked pseudogenes and cancer proves that understanding RNA networks is more complicated than expected.
George A Calin
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

FGF9 attenuates osteoarthritis progression through the NRF2/GPX3 antioxidant axis

Bone & Joint Research
Aims: Osteoarthritis (OA), a prevalent age-related joint disease affecting over 250 million people globally, currently lacks effective disease-modifying treatments.
Yuan-Shun Lo, Tsung-Ming Chen, Teng-Le Huang, Yu-Chia Liu, Chu-Han Chang, Chia-Yang Chen, Hung-Lun Hsieh, Chun-Hao Tsai, Yi-Xue Yeow, Chia-Jou Wang, Ya-Huey Chen   +10 more
doaj   +1 more source

The deleted in oral cancer (DOC1 aka CDK2AP1) tumor suppressor gene is downregulated in oral squamous cell carcinoma by multiple microRNAs

Cell Death and Disease, 2023
Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1; also known as deleted in oral cancer or DOC1) is a tumor suppressor gene known to play functional roles in both cell cycle regulation and in the epigenetic control of embryonic stem cell ...
Roberto Stabile, Mario Román Cabezas, Mathijs P. Verhagen, Francesco A. Tucci, Thierry P. P. van den Bosch, Maria J. De Herdt, Berdine van der Steen, Alex L. Nigg, Meng Chen, Cristina Ivan, Masayoshi Shimizu, Senada Koljenović, Jose A. Hardillo, C. Peter Verrijzer, Robert J. Baatenburg de Jong, George A. Calin, Riccardo Fodde   +16 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

RNA-RNA and RNA-protein interactions in coronavirus replication and transcription [PDF]

RNA Biology, 2011
Coronavirus (CoV) RNA synthesis includes the replication of the viral genome, and the transcription of sgRNAs by a discontinuous mechanism. Both processes are regulated by RNA sequences such as the 5' and 3' untranslated regions (UTRs), and the transcription regulating sequences (TRSs) of the leader (TRS-L) and those preceding each gene (TRS-Bs). These
Sola, Isabel, Mateos-Gomez, Pedro A., Almazan, Fernando, Zuñiga, Sonia, Enjuanes, Luis   +4 more
openaire   +3 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source