Results 141 to 150 of about 303,152 (296)

Hijacking the Host Clock: A Nematode Effector Antagonizes Soybean Circadian Defense and Translation Control

Advanced Science, EarlyView.
Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang, Yufeng Xu, Yanfei Hu, Lijun Cao, Ru Jiang, Changtian Chen, Rick Masonbrink, Thomas Maier, Yuchen Tu, Yabo Shi, Enhui Liu, Lingan Kong, Chan Guo, Wei Zhao, Peng Shi, Wenzhen Du, Andrew Severin, Thomas Baum, Deliang Peng, Huan Peng, Mian Zhou, Wei Wang   +21 more
wiley   +1 more source

Direct dsRNA preparation by promoter-free RCT and RNase H cleavage using one circular dsDNA template with a mismatched bubble. [PDF]

RNA, 2023
Chen H, Gu Z, Yang L, Liu F, An R, Ge Y, Liang X.   +6 more
europepmc   +1 more source

RNase H confirmed strong binding sites in vRNA8 for microarray probes.

, 2016
RNase H confirmed strong binding sites in vRNA8 for microarray probes.
Elzbieta Kierzek (27228), Marta Soszynska-Jozwiak (816777), Elzbieta Lenartowicz (722714), Julita Kesy (2157010), Douglas H. Turner (27232), Ryszard Kierzek (27233), Paula Michalak (816778), Walter N. Moss (159608), Agnieszka Ruszkowska (2157007)   +8 more
core   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

Boron Clusters as Enhancers of RNase H Activity in the Smart Strategy of Gene Silencing by Antisense Oligonucleotides. [PDF]

Int J Mol Sci, 2022
Kaniowski D, Kulik K, Suwara J, Ebenryter-Olbińska K, Nawrot B.   +4 more
europepmc   +1 more source

Structural basis for dual roles of Aar2p in U5 snRNP assembly

, 2013
Yeast U5 small nuclear ribonucleoprotein particle (snRNP) is assembled via a cytoplasmic precursor that contains the U5-specific Prp8 protein but lacks the U5-specific Brr2 helicase.
Jovin, S.M., Beggs, J., Wahl, M., Cristao, V., Heroven, A., Cristão, V.F., Beggs, J.D., Santos, K., Santos, K.F., Holton, N., Weber, G., Mozaffari-Jovin, S., Heroven, A.C., Wahl, M.C., Lührmann, R.   +14 more
core   +1 more source

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Characterization of Escherichia coli RNase H Discrimination of DNA Phosphorothioate Stereoisomers. [PDF]

Nucleic Acid Ther, 2021
Kiełpiński ŁJ, Funder ED, Schmidt S, Hagedorn PH.   +3 more
europepmc   +1 more source

Carboxyl-terminus of RNase H Contributes to Hepatitis B Virus Genome Replication

, 2015
Multi-functional polymerase of hepatitis B virus (HBV) participates in pregenomic RNA (pgRNA) encapsidation and DNA synthesis, and acts as a primer for minus-strand DNA initiation.
Jung, Jaesung, Kim, Kyongmin, Lee, Hye-Jin   +2 more
core  

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source