Structural and functional investigation of the human snRNP assembly factor AAR2 in complex with the RNase H-like domain of PRPF8. [PDF]
Acta Crystallogr D Struct Biol, 2022 Preussner M +6 more
europepmc +1 more source
Structural studies of nucleic acids and proteins involved in nucleic acid recognition [PDF]
, 2010 This PhD thesis focuses on the structural analysis of the protein-nucleic acid recognition. In particular the research work has been focalized on two different kinds of proteins and their nucleotide ligands.
Russo Krauss, Irene
core
Advanced Science, EarlyView.We developed an ultrasound‐controlled biomimetic nanoplatform, mRNA/V@M NPs, to co‐deliver CD74 mRNA and V‐9302 for fibrotic TNBC therapy. CD74 mRNA reprograms myCAFs into antigen‐presenting apCAF cells through the CD74‐MHC II pathway, while V‐9302 induces ICD and activates MHC I‐CD8+ T cell immunity.
Chen Ai +9 more
wiley +1 more source
RNase H is an exo- and endoribonuclease with asymmetric directionality, depending on the binding mode to the structural variants of RNA:DNA hybrids. [PDF]
Nucleic Acids Res, 2022 Lee H +6 more
europepmc +1 more source
Carboxyl-terminus of RNase H Contributes to Hepatitis B Virus Genome Replication
, 2015 Multi-functional polymerase of hepatitis B virus (HBV) participates in pregenomic RNA (pgRNA) encapsidation and DNA synthesis, and acts as a primer for minus-strand DNA initiation.
Jung, Jaesung +2 more
core +1 more source
Advanced Science, EarlyView.The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang +12 more
wiley +1 more source
Correction: Ultrasensitive fluorescent aptasensor for CRP detection based on the RNase H assisted DNA recycling signal amplification strategy. [PDF]
RSC Adv, 2022 Liu Z +9 more
europepmc +1 more source
Advanced Science, EarlyView.In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen +5 more
wiley +1 more source
Endogenous reverse transcriptase and RNase H-mediated antiviral mechanism in embryonic stem cells. [PDF]
Cell Res, 2021 Wu J +17 more
europepmc +1 more source
A Panel of Circulating Exosomal sncRNAs Associated With Lung Cancer Risk up to 10 Years in Advance
Advanced Science, EarlyView.Lung cancer is often diagnosed too late, and current screening overlooks many people at risk. In a long‐term study of smokers, a panel of small non‐coding RNAs carried in blood exosomes signals elevated lung cancer risk up to ten years before diagnosis, pointing toward a blood‐based tool for earlier risk detection.
Zhuokun Feng +12 more
wiley +1 more source