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HIV-1 RT-Associated RNase H review

Archives of Pharmaceutical Sciences Ain Shams University, 2018
HIV-RT is an essential enzyme for HIV replication it comprises two associated functions: RNA- and DNA-dependent DNA polymerase (RDDP & DDDP) and ribonuclease H (RNase H).
Madonna M. A. Mitry, Nermin S. Abdou, Rabah A. T. Serya   +2 more
doaj   +2 more sources

RNase H sequence preferences influence antisense oligonucleotide efficiency. [PDF]

Nucleic Acids Res, 2019
RNase H cleaves RNA in RNA-DNA duplexes. It is present in all domains of life as well as in multiple viruses and is essential for mammalian development and for human immunodeficiency virus replication. Here, we developed a sequencing-based method to measure the cleavage of thousands of different RNA-DNA duplexes and thereby comprehensively ...
Kiełpiński ŁJ, Hagedorn PH, Lindow M, Vinther J.   +3 more
europepmc   +8 more sources

Discovery of <i>N</i>-Hydroxypyridinedione-Based Inhibitors of HBV RNase H: Design, Synthesis, and Extended SAR Studies. [PDF]

Int J Mol Sci
Chotzalli D, Pardali V, Walden HM, Perivolaris D, Moianos D, Makri M, Drakopoulos A, Giannakopoulou E, Tajwar R, Woodson ME, Tavis JE, Zoidis G.   +11 more
europepmc   +3 more sources

Activation/Attenuation Model for RNase H [PDF]

Journal of Biological Chemistry, 1998
James L. Keck, Eric R. Goedken, Susan Marqusee   +2 more
openalex   +2 more sources

The “Connection” Between HIV Drug Resistance and RNase H [PDF]

Viruses, 2010
Currently, nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) are two classes of antiretroviral agents that are approved for treatment of HIV-1 infection. Since both NRTIs and NNRTIs target the
Krista A. Delviks-Frankenberry, Vinay K. Pathak, Galina N. Nikolenko   +2 more
doaj   +3 more sources

RNase H and Its Effects on PCR [PDF]

BioTechniques, 2002
Swamy K. Polumuri, Abdul Ruknudin, Dan H. Schulze   +2 more
doaj   +3 more sources

RNase H As Gene Modifier, Driver of Evolution and Antiviral Defense [PDF]

Frontiers in Microbiology, 2017
Retroviral infections are ‘mini-symbiotic’ events supplying recipient cells with sequences for viral replication, including the reverse transcriptase (RT) and ribonuclease H (RNase H).
Karin Moelling, Karin Moelling, Felix Broecker, Giancarlo Russo, Shinichi Sunagawa   +4 more
doaj   +2 more sources

Synthesis, biophysical properties, and RNase H activity of 6'-difluoro[4.3.0]bicyclo-DNA. [PDF]

Beilstein J Org Chem, 2019
Frei S, Katolik AK, Leumann CJ.
europepmc   +3 more sources

RNase H-defective mutants of Escherichia coli [PDF]

Journal of Bacteriology, 1986
Tokio Kogoma
openalex   +4 more sources

Dual RNA-seq in filarial nematodes and Wolbachia endosymbionts using RNase H based ribosomal RNA depletion. [PDF]

Front Microbiol
Cantin LJ, Gregory V, Blum LN, Foster JM.   +3 more
europepmc   +3 more sources