Results 21 to 30 of about 290,253 (274)
RNases H: Multiple roles in maintaining genome integrity
DNA Repair, 2019 Susana M. Cerritelli, Robert J. Crouch
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Nature Communications, 2023 In the gastric pathogen Helicobacter pylori, post-transcriptional regulation relies strongly on the activity of the essential ribonuclease RNase J. Here, we elucidated the crystal and cryo-EM structures of RNase J and determined that it assembles into ...
Alejandro Tejada-Arranz +10 more
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The catalytic mechanism, metal dependence, substrate specificity, and biodiversity of ribonuclease H
Frontiers in Microbiology, 2022 Ribonucleoside monophosphates are inevitably misincorporated into the DNA genome inside cells, and they need to be excised to avoid chromosome instability.
Jing Pang, Qinyu Guo, Zheng Lu
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Molecules, 2020 The persistence of the AIDS epidemic, and the life-long treatment required, indicate the constant need of novel HIV-1 inhibitors. In this scenario the HIV-1 Reverse Transcriptase (RT)-associated ribonuclease H (RNase H) function is a promising drug ...
Angela Corona +5 more
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Insights into the structure and activity of prototype foamy virus RNase H
Retrovirology, 2012 Background RNase H is an endonuclease that hydrolyzes the RNA strand in RNA/DNA hybrids. Retroviral reverse transcriptases harbor a C-terminal RNase H domain whose activity is essential for viral replication.
Leo Berit +4 more
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Evolution of ribonuclease H genes in prokaryotes to avoid inheritance of redundant genes
BMC Evolutionary Biology, 2007 Background A theoretical model of genetic redundancy has proposed that the fates of redundant genes depend on the degree of functional redundancy, and that functionally redundant genes will not be inherited together.
Tomita Masaru +2 more
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Polypurine Tract Formation by Ty1 RNase H [PDF]
Journal of Biological Chemistry, 2001 To better understand the mechanism by which Ty1 RNase H creates the polypurine tract (PPT) primer, we have demonstrated the polymerase-dependent hydrolytic activity of Ty1 reverse transcriptase (RT) during minus-strand synthesis. Using RNase H and polymerase mutants of the recombinant Ty1 RT protein, we show that the two domains of Ty1 RT can act ...
M, Wilhelm +4 more
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Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6. [PDF]
PLoS ONE, 2016 The DNA polymerase and ribonuclease H (RNase H) activities of human immunodeficiency virus type 1 (HIV-1) are needed for the replication of the viral genome and are validated drug targets.
Angela Corona +10 more
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RNase H1 and H2 Are Differentially Regulated to Process RNA-DNA Hybrids
Cell Reports, 2019 Summary: RNA-DNA hybrids are tightly regulated to ensure genome integrity. The RNase H enzymes RNase H1 and H2 contribute to chromosomal stability through the removal of RNA-DNA hybrids.
Arianna Lockhart +7 more
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RNase H eliminates R-loops that disrupt DNA replication but is nonessential for efficient DSB repair. [PDF]
EMBO Rep, 2018 Zhao H, Zhu M, Limbo O, Russell P.
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