Results 121 to 130 of about 436,820 (281)

Dissolving Microneedle for Maintaining the Integrity of HPV Virus‐Like Particles Enabling Durable Sterile Protection Across Various Mucosal Tissues

Advanced Healthcare Materials, EarlyView.
A novel dissolving microneedle platform preserves HPV virus‐like particle (VLP) immunogenicity by maintaining structural integrity, crucial for eliciting potent immune responses. Buccal administration induces robust immune response, high neutralizing antibody titers, and durable sterile protection across oral and vaginal mucosal sites.
Hyemi Kim, Inhyuk Hwang, Juhee Seo, Chaiwon Kim, In‐Jeong Choi, Miran Kang, Min‐Seok Rha, Youngjae Hong, Jooyoung Kim, Seung‐Ki Baek, Jung‐Hwan Park, Hyung‐Ju Cho, Kihyuck Kwak   +12 more
wiley   +1 more source

Endogenous Ribonucleases: Therapeutic Targeting of the Transcriptome Through Oligonucleotide-Triggered RNA Inactivation

Biomolecules
The selective regulation of gene expression at the RNA level represents a rapidly evolving field offering substantial clinical potential. This review examines the molecular mechanisms of intracellular enzymatic systems that utilize single-stranded ...
Daria A. Chiglintseva, Olga A. Patutina, Marina A. Zenkova   +2 more
doaj   +1 more source

Impact of Nanoparticle Stiffness on Endosomal Escape and Signaling Pathways in Cytosolic Delivery

Advanced Healthcare Materials, EarlyView.
Nanoparticle (NP) stiffness affects cellular uptake, but its impact on intracellular distribution remains unclear. This study synthesizes silica nanocapsules with varying stiffness, inspired by viral mechanisms, and applies assays to measure cellular uptake and escape efficiency.
Yali Zhang, Yue Hui, Zichao Guo, Dawei Liu, Yun Liu, Huajian Gao, Chun‐Xia Zhao   +6 more
wiley   +1 more source

Bistability of an In Vitro Synthetic Autoregulatory Switch [PDF]

, 2011
The construction of synthetic biochemical circuits is an essential step for developing quantitative understanding of information processing in natural organisms.
Kim, Jongmin, Subsoontorn, Pakpoom, Winfree, Erik   +2 more
core  

An immunological determinant of RNase P protein is conserved between Escherichia coli and humans. [PDF]

, 1989
Mark J. Mamula, Madeline F. Baer, J. Carl Craft, Sidney Altman   +3 more
openalex   +1 more source

Suppressing t(4;11) Acute Leukemia by Lipopolymer Nanoparticle Delivery of siRNA Targeting KMT2A::AFF1 with Enhanced Extrahepatic Delivery

Advanced Healthcare Materials, EarlyView.
This study introduces a new lipopolymer nanoparticle (LPNP) system that efficiently delivers siRNA to leukemia cells. The LPNPs silence the leukemia fusion gene KMT2A::AFF1, induce apoptosis, and decrease leukemia burden in mice. These results demonstrate the potential of LPNPs as a targeted siRNA therapy for acute lymphoblastic leukemia.
Mohammad Nasrullah, Remant KC, Amarnath Praphakar Rajendran, Saba Abbasi Dezfouli, Cezary Kucharski, Xiaoyan Jiang, Spencer B. Gibson, Joseph Brandwein, Olaf Heidenreich, Hasan Uludağ   +9 more
wiley   +1 more source

Cleavage kinetics of human mitochondrial RNase P and contribution of its non-nuclease subunits. [PDF]

Nucleic Acids Res, 2023
Vilardo E, Toth U, Hazisllari E, Hartmann RK, Rossmanith W.   +4 more
europepmc   +1 more source

Porous Decellularized Nerve Grafts Facilitate Recellularization and Nerve Regeneration in a Rat Model of Critical Long‐Gap Peripheral Nerve Injury

Advanced Healthcare Materials, EarlyView.
A decellularized nerve graft (DNG) is modified to generate a porous DNG (PDNG). The PDNG is used to repair a 30‐mm peripheral nerve injury (PNI) defect, and is compared with isograft, serving as the standard, and DNG, a widely used alternative. The result shows that PDNG facilitated nerve regeneration in long‐gap PNI, evidenced by better‐aligned axonal
Olawale Alimi Alimi, Mitchell Kuss, Wen Xue, Bo Liu, Mena Asha Krishnan, Tianshu Pan, Zhi He, Han‐Jun Wang, Yuguo Lei, Kai Yang, Bin Duan   +10 more
wiley   +1 more source

Recognition of tRNA^His in an RNase P-Free Nanoarchaeum. [PDF]

Microbiol Spectr, 2023
Ivanesthi IR, Rida GRN, Setiawibawa AA, Tseng YK, Muammar A, Wang CC.   +5 more
europepmc   +1 more source

The POP1 gene encodes a protein component common to the RNase MRP and RNase P ribonucleoproteins. [PDF]

, 1994
Zoi Lygerou, Philip Mitchell, E Petfalski, Bertrand Séraphin, David Tollervey   +4 more
openalex   +1 more source