In vitro reconstitution and analysis of eukaryotic RNase P RNPs [PDF]
Nucleic Acids Research, 2018 RNase P is a ubiquitous site-specific endoribonuclease primarily responsible for the maturation of tRNA. Throughout the three domains of life, the canonical form of RNase P is a ribonucleoprotein (RNP) built around a catalytic RNA.
Anna Perederina +2 more
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Human RNase P: overview of a ribonuclease of interrelated molecular networks and gene-targeting systems. [PDF]
RNA, 2023 The seminal discovery of ribonuclease P (RNase P) and its catalytic RNA by Sidney Altman has not only revolutionized our understanding of life, but also opened new fields for scientific exploration and investigation.
Jarrous N, Liu F.
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Structural basis of RNA processing by human mitochondrial RNase P. [PDF]
Nat Struct Mol Biol, 2021 Human mitochondrial transcripts contain messenger and ribosomal RNAs flanked by transfer RNAs (tRNAs), which are excised by mitochondrial RNase (mtRNase) P and Z to liberate all RNA species. In contrast to nuclear or bacterial RNase P, mtRNase P is not a
Bhatta A +3 more
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The Dynamic Network of RNP RNase P Subunits. [PDF]
Int J Mol Sci, 2021 Ribonuclease P (RNase P) is an important ribonucleoprotein (RNP), responsible for the maturation of the 5′ end of precursor tRNAs (pre-tRNAs). In all organisms, the cleavage activity of a single phosphodiester bond adjacent to the first nucleotide of the
Shaukat AN +3 more
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Inactivation of RNase P in Escherichia coli significantly changes post-transcriptional RNA metabolism. [PDF]
Mol Microbiol, 2022 Ribonuclease P (RNase P), which is required for the 5'‐end maturation of tRNAs in every organism, has been shown to play a limited role in other aspects of RNA metabolism in Escherichia coli.
Mohanty BK, Kushner SR.
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The many faces of RNA-based RNase P, an RNA-world relic. [PDF]
Trends Biochem Sci, 2021 Phan HD +3 more
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The conformational space of RNase P RNA in solution. [PDF]
NatureLee YT +9 more
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Coevolution of RNA and protein subunits in RNase P and RNase MRP, two RNA processing enzymes. [PDF]
J Biol ChemZhou B +5 more
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Engineered RNase P Ribozymes Effectively Inhibit the Infection of Murine Cytomegalovirus in Animals [PDF]
Theranostics, 2018 Rationales: Gene-targeting ribozymes represent promising nucleic acid-based gene interference agents for therapeutic application. We previously used an in vitro selection procedure to engineer novel RNase P-based ribozyme variants with enhanced targeting
Wei Li +11 more
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Minimal and RNA-free RNase P in Aquifex aeolicus [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2017 Astrid I. Nickel +7 more
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