Results 41 to 50 of about 20,593,893 (291)
P finder: genomic and metagenomic annotation of RNase P RNA gene (rnpB)
BMC Genomics, 2020 Background The rnpB gene encodes for an essential catalytic RNA (RNase P). Like other essential RNAs, RNase P’s sequence is highly variable. However, unlike other essential RNAs (i.e.
J. Christopher Ellis
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Architecture and Function of the Human Endonucleases RNase P and RNase MRP [PDF]
IUBMB Life, 2000 AbstractIn the past decade, important advances have been made in our knowledge of the composition of human RNase MRP and RNase P complexes. Both ribonucleoprotein particles function as endonucleases and contain RNA components that are structurally related.
Eenennaam, H. van +3 more
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Insights into the structure and activity of prototype foamy virus RNase H
Retrovirology, 2012 Background RNase H is an endonuclease that hydrolyzes the RNA strand in RNA/DNA hybrids. Retroviral reverse transcriptases harbor a C-terminal RNase H domain whose activity is essential for viral replication.
Leo Berit +4 more
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Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP
Nature Communications, 2020 Ribozyme-based RNase MRP is an essential eukaryotic enzyme involved in the maturation of rRNA and is evolutionarily related to RNase P. Here, the authors present the 3.0 Å cryo-EM structure of the S.
Anna Perederina +6 more
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Influence of Conformation of M. tuberculosis RNase P Protein Subunit on Its Function. [PDF]
PLoS ONE, 2016 RNase P is an essential enzyme that processes 5' end leader sequence of pre-tRNA to generate mature tRNA. The bacterial RNase Ps contain a RNA subunit and one protein subunit, where the RNA subunit contains the catalytic activity.
Alla Singh +3 more
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Evolution and thermodynamics of the slow unfolding of hyperstable monomeric proteins
BMC Evolutionary Biology, 2010 Background The unfolding speed of some hyperthermophilic proteins is dramatically lower than that of their mesostable homologs. Ribonuclease HII from the hyperthermophilic archaeon Thermococcus kodakaraensis (Tk-RNase HII) is stabilized by its remarkably
Koga Yuichi +8 more
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Human serum RNase-L level is inversely associated with metabolic syndrome and age
Cardiovascular Diabetology, 2017 Background Ribonuclease-L (RNase-L) was known to be a ubiquitous enzyme involved in several cellular functions, especially innate immunity. It was recently shown to participate in adipogenesis in rodents.
Yi-Ting Wang +6 more
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Mouse ribonuclease III. cDNA structure, expression analysis, and chromosomal location
BMC Genomics, 2002 Background Members of the ribonuclease III superfamily of double-stranded(ds)-RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells. A human RNase III orthologue has been implicated in
Nicholson Rhonda H +2 more
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RNase P — a ‘Scarlet Pimpernel’ [PDF]
Molecular Microbiology, 1995 RNase P is responsible for the maturation of the 5′‐termini of tRNA molecules in all cells studied to date. This ribonucleoprotein has to recognize and identify its cleavage site on a large number of different precursors. This review covers what is currently known about the function of the catalytic subunit of Escherichia coli RNase P, M1 RNA, and the ...
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Identity of the RNase MRP– and RNase P–associated Th/To autoantigen [PDF]
Arthritis & Rheumatism, 2002 AbstractObjectiveTo characterize the molecular identity of the Th/To autoantigen, which is targeted by autoantibodies in scleroderma and which is associated with the human RNase MRP and RNase P ribonucleoprotein complexes.MethodsProteins immunoprecipitated by anti‐Th/To+ patient antisera from biotinylated total HeLa cell extracts were analyzed by ...
Eenennaam, H. van +5 more
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