Results 31 to 40 of about 25,923,055 (288)
Insights into the structure and activity of prototype foamy virus RNase H
Retrovirology, 2012 Background RNase H is an endonuclease that hydrolyzes the RNA strand in RNA/DNA hybrids. Retroviral reverse transcriptases harbor a C-terminal RNase H domain whose activity is essential for viral replication.
Leo Berit +4 more
doaj +1 more source
Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP
Nature Communications, 2020 Ribozyme-based RNase MRP is an essential eukaryotic enzyme involved in the maturation of rRNA and is evolutionarily related to RNase P. Here, the authors present the 3.0 Å cryo-EM structure of the S.
Anna Perederina +6 more
doaj +1 more source
Influence of Conformation of M. tuberculosis RNase P Protein Subunit on Its Function. [PDF]
PLoS ONE, 2016 RNase P is an essential enzyme that processes 5' end leader sequence of pre-tRNA to generate mature tRNA. The bacterial RNase Ps contain a RNA subunit and one protein subunit, where the RNA subunit contains the catalytic activity.
Alla Singh +3 more
doaj +1 more source
Evolution and thermodynamics of the slow unfolding of hyperstable monomeric proteins
BMC Evolutionary Biology, 2010 Background The unfolding speed of some hyperthermophilic proteins is dramatically lower than that of their mesostable homologs. Ribonuclease HII from the hyperthermophilic archaeon Thermococcus kodakaraensis (Tk-RNase HII) is stabilized by its remarkably
Koga Yuichi +8 more
doaj +1 more source
Human serum RNase-L level is inversely associated with metabolic syndrome and age
Cardiovascular Diabetology, 2017 Background Ribonuclease-L (RNase-L) was known to be a ubiquitous enzyme involved in several cellular functions, especially innate immunity. It was recently shown to participate in adipogenesis in rodents.
Yi-Ting Wang +6 more
doaj +1 more source
Mouse ribonuclease III. cDNA structure, expression analysis, and chromosomal location
BMC Genomics, 2002 Background Members of the ribonuclease III superfamily of double-stranded(ds)-RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells. A human RNase III orthologue has been implicated in
Nicholson Rhonda H +2 more
doaj +1 more source
Identity of the RNase MRP– and RNase P–associated Th/To autoantigen [PDF]
Arthritis & Rheumatism, 2002 AbstractObjectiveTo characterize the molecular identity of the Th/To autoantigen, which is targeted by autoantibodies in scleroderma and which is associated with the human RNase MRP and RNase P ribonucleoprotein complexes.MethodsProteins immunoprecipitated by anti‐Th/To+ patient antisera from biotinylated total HeLa cell extracts were analyzed by ...
Eenennaam, H. van +5 more
openaire +3 more sources
RNase P-Mediated Sequence-Specific Cleavage of RNA by Engineered External Guide Sequences
Biomolecules, 2015 The RNA cleavage activity of RNase P can be employed to decrease the levels of specific RNAs and to study their function or even to eradicate pathogens. Two different technologies have been developed to use RNase P as a tool for RNA knockdown.
Merel Derksen +2 more
doaj +1 more source
CHIMIA, 2018 Ribonuclease P (RNase P) is a class of enzymes involved in the processing of precursor tRNAs to remove their 5'-leader sequences. Ribonuclease P enzymes are classified into two completely distinct classes, i.e.
Yuri Nozawa +3 more
doaj +1 more source
The deduced amino acid sequence alignment for the S-RNase (PcS34-RNase),
, 2011 S-RNase (PdoS5-RNase), . S-RNase (PaS1-RNase), . S-RNase (PdS11-RNase), and . S-RNase (PtS8-RNase). The asterisks indicate the five amino acid residues that are different between . S-RNase and . S-RNase. Conserved nucleotides are shown on a darkened
Daniel Potter (52965) +5 more
core +1 more source