Results 31 to 40 of about 20,593,893 (291)

A new role for proteins subunits of RNase P: stabilization of the telomerase holoenzyme

Microbial Cell, 2020
RNase P, an RNA-protein complex, is essential for processing tRNAs. Three of the ten protein subunits of Saccharomyces cerevisiae RNase P (and a related complex, RNase MRP) co-purify with yeast telomerase, another RNA-protein complex.
P. Daniela Garcia, Virginia A. Zakian
doaj   +1 more source

The Bacillus subtilis RNase P holoenzyme contains two RNase P RNA and two RNase P protein subunits [PDF]

RNA, 2001
Ribonuclease P (RNase P) catalyzes the 5' maturation of precursor tRNA transcripts and, in bacteria, is composed of a catalytic RNA and a protein. We investigated the oligomerization state and the shape of the RNA alone and the holoenzyme of Bacillus subtilis RNase P in the absence of substrate by synchrotron small-angle X-ray scattering and affinity ...
X W, Fang, X J, Yang, K, Littrell, S, Niranjanakumari, P, Thiyagarajan, C A, Fierke, T R, Sosnick, T, Pan   +7 more
openaire   +2 more sources

Function and assembly of a chromatin-associated RNase P that is required for efficient transcription by RNA polymerase I. [PDF]

PLoS ONE, 2008
Human RNase P has been initially described as a tRNA processing enzyme, consisting of H1 RNA and at least ten distinct protein subunits. Recent findings, however, indicate that this catalytic ribonucleoprotein is also required for transcription of small ...
Robert Reiner, Natalie Krasnov-Yoeli, Yana Dehtiar, Nayef Jarrous   +3 more
doaj   +1 more source

Crystallization and crystallographic analysis of an Arabidopsis nuclear proteinaceous RNase P [PDF]

, 2015
RNase P activity is ubiquitous and involves the 5' maturation of precursor tRNAs. For a long time, it was thought that all RNases P were ribonucleoproteic enzymes.
Giegé, Philippe, Sauter, C. (Claude), Pinker, F. (Franziska), Giegé, P. (Philippe), Pinker, Franziska, Sauter, Claude   +5 more
core   +1 more source

Is alba an RNase P subunit? [PDF]

RNA Biology, 2007
It has been suggested that Alba, a well-established chromatin protein in Archaea, is also a subunit of the archaeal RNase P holoenzyme, based on the observation that the homolog of this protein in humans has been shown to be associated with RNase P activity.
J Chris, Ellis, Jeffrey, Barnes, James W, Brown   +2 more
openaire   +2 more sources

Zebrafish RNase T2 genes and the evolution of secretory ribonucleases in animals

BMC Evolutionary Biology, 2009
Background Members of the Ribonuclease (RNase) T2 family are common models for enzymological studies, and their evolution has been well characterized in plants.
Essner Jeffrey J, Umanskaya Alisa, Wang Ying, Rizhsky Ludmila, Hillwig Melissa S, MacIntosh Gustavo C   +5 more
doaj   +1 more source

The catalytic core of RNase P [PDF]

Nucleic Acids Research, 1996
A deletion mutant of the catalytic RNA component of Escherichia coli RNase P missing residues 87-241 retains the ability to interact with the protein component to form a functional catalyst. The deletion of this phylogenetically conserved region significantly increases the Km, indicating that the deleted structures may be important for binding to the ...
C J, Green, R, Rivera-León, B S, Vold
openaire   +2 more sources

Membrane recognition and dynamics of the RNA Degradosome [PDF]

, 2015
RNase E, which is the central component of the multienzyme RNA degradosome, serves as a scaffold for interaction with other enzymes involved in mRNA degradation including the DEAD-box RNA helicase RhlB.
Luisi, Ben, Syma Khalid (580907), Bouvier, Marie, Turlan, Catherine, Kebalo, J.M., Peyron, Pascale, Leonora Poljak, Peter J Bond, Peter J. Bond (688987), Strahl, H., Poljak, Leonora, Carpousis, A.J., Khalid, Syma, Ben F. Luisi (688991), Turlan, C., Henrik Strahl, Strahl, Henrik, Syma Khalid, Khalid, S., Jean-Marie Kebalo, Pascale Peyron, Henrik Strahl (688985), Catherine Turlan, Bouvier, M., Marie Bouvier, Agamemnon J. Carpousis (12453), Jean-Marie Kebalo (688988), Agamemnon J Carpousis, Pascale Peyron (239058), Leendert Hamoen (688990), Bond, Peter J., Bond, P.J., Ben F Luisi, Catherine Turlan (688986), Bond, Peter, Viollier, Patrick H., Marie Bouvier (260008), Hamoen, L.; id_orcid, Hamoen, Leendert, Luisi, Ben F., Carpousis, Agamemnon J., Peyron, P., Poljak, L., Luisi, B.F., Kebalo, Jean-Marie, Leendert Hamoen, Leonora Poljak (688989), Carpousis, Agamemnon, Hamoen, L.   +48 more
core   +2 more sources

Evolution of ribonuclease H genes in prokaryotes to avoid inheritance of redundant genes

BMC Evolutionary Biology, 2007
Background A theoretical model of genetic redundancy has proposed that the fates of redundant genes depend on the degree of functional redundancy, and that functionally redundant genes will not be inherited together.
Tomita Masaru, Kochiwa Hiromi, Kanai Akio   +2 more
doaj   +1 more source

Genetic diversity of human RNase 8

BMC Genomics, 2012
Background Ribonuclease 8 is a member of the RNase A family of secretory ribonucleases; orthologs of this gene have been found only in primate genomes. RNase 8 is a divergent paralog of RNase 7, which is lysine-enriched, highly conserved, has prominent ...
Chan Calvin C, Moser Jennifer M, Dyer Kimberly D, Percopo Caroline M, Rosenberg Helene F   +4 more
doaj   +1 more source