Results 51 to 60 of about 25,923,055 (288)
Human RNase H1 is associated with protein P32 and is involved in mitochondrial pre-rRNA processing. [PDF]
PLoS ONE, 2013 Mammalian RNase H1 has been implicated in mitochondrial DNA replication and RNA processing and is required for embryonic development. We identified the mitochondrial protein P32 that binds specifically to human RNase H1, but not human RNase H2. P32 binds
Hongjiang Wu +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Modeling the Thermoproteaceae RNase P RNA [PDF]
RNA Biology, 2012 The RNA component of the RNase P complex is found throughout most branches of the tree of life and is principally responsible for removing the 5' leader sequence from pre-tRNA transcripts during tRNA maturation. RNase P RNA has a number of universal core features, however variations in sequence and structure found in homologs across the tree of life ...
Chan, Patricia P. +2 more
openaire +2 more sources
CD spectroscopy of RNase P protein components.
, 2016 A. Far-UV CD spectra of the two protein preparations from 205–250 nm at different temperatures. B. CD profile of RNase P-U protein and RNase P-G protein within the temperature range of 20–80°C. C.
Shah Ubaid-ullah (487293) +3 more
core +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
, 2023 reservedThe worldwide spread of bacterial resistance against conventional antibiotics motivates the development of novel antimicrobial drugs. Bacterial biofilms are highly present in the hospital setting and are responsible for several types of ...
CENERE, GIOVANNI
core
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Structural and functional basis for RNA cleavage by Ire1
BMC Biology, 2011 Background The unfolded protein response (UPR) controls the protein folding capacity of the endoplasmic reticulum (ER). Central to this signaling pathway is the ER-resident bifunctional transmembrane kinase/endoribonuclease Ire1.
Stroud Robert M +7 more
doaj +1 more source
, 2016 A. Indicated concentrations of magnesium and ammonium ions were used to assay the pre-tRNA cleavage by RNase P RNA and RNase P-G protein. The reactions contained 50 nM of RNase P RNA and 100 nM of RNase P-G protein. B.
Shah Ubaid-ullah (487293) +3 more
core +1 more source