Results 81 to 90 of about 430,076 (284)
Evolutionary conundrum of RNase P: from a catalytic RNA form to a protein only enzyme form [PDF]
, 2019 RNaza P je esencijalna endonukleaza koja katalizira procesiranje 5'-vodećeg slijeda pre-tRNA. Postoje dva tipa RNaze P: RNA-ovisni enzim tj ribonukleoprotein te isključivo proteinska RNaza P (PRORP).
Radman, Katarina
core
In vitro transactivation of Bacillus subtilis RNase P RNA [PDF]
, 2001 Deletion of the ‘signature’ PL5.1 stem-loop structure of a Type II RNase P RNA diminished its catalytic activity. Addition of PL5.1 in trans increased catalytic efficiency (kcat/KM) rather than kcat. Transactivation was due to the binding of a single PL5.
Kim, Hadong +4 more
core +1 more source
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Cryo-electron microscopy structure of an archaeal ribonuclease P holoenzyme
Nature Communications, 2019 Ribonulease P is a conserved ribozyme present in all kingdoms of life that is involved in the 5′ maturation step of tRNAs. Here the authors determine the structure of an archaeal RNase P holoenzyme that reveals how archaeal RNase P recognizes its tRNA ...
Futang Wan +8 more
doaj +1 more source
Reconstitution of Pyrobaculum aerophilum RNase P, a catalytic ribonucleoprotein involved in tRNA maturation [PDF]
, 2011 RNase P, an essential ribonucleoprotein (RNP) complex, is responsible for the processing and removal of 5′ tRNA leaders. While RNase P-catalyzed tRNA maturation is common to the three domains of life, the subunit make-up of this enzyme is quite different.
Smith, Derek
core
Crosslinking studies of the bacterial RNase P holoenzyme and functional characterisation of the novel protein-only RNase P from Arabidopsis thaliana [PDF]
, 2012 Ribonuclease P (RNase P) is the ubiquitous processing enzyme that generates the mature 5'-termini of tRNA molecules. In Bacteria and Archaea the enzyme is a ribonucleoprotein, whereas in some Eukarya the RNAse P is exclusively proteinaceous. This work is
Pavlova, Liudmila Viktorovna
core +1 more source
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source
BMC Genomics, 2010 Background Effective bioinformatics solutions are needed to tackle challenges posed by industrial-scale genome annotation. We present Bcheck, a wrapper tool which predicts RNase P RNA genes by combining the speed of pattern matching and sensitivity of ...
Stadler Peter F +3 more
doaj +1 more source
Molecular Oncology, EarlyView.A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul +11 more
wiley +1 more source
Inhibition of gene expression by RNase P
New Biotechnology, 2010 The ability to interfere with gene expression is of crucial importance to unravel the function of genes and is also a promising therapeutic strategy. Here we discuss methodologies for inhibition of target RNAs based on the cleavage activity of the essential enzyme, Ribonuclease P (RNase P).
Eirik Wasmuth Lundblad, Sidney Altman
openaire +2 more sources