Results 101 to 110 of about 21,290,096 (239)

RNAi in the Rhizarian Phytopathogen Plasmodiophora brassicae: The Causal Agent of Clubroot Disease in Cruciferous Crops

Advanced Science, EarlyView.
This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Xiong Zhang, Yupo Wu, Jiachang Hou, Lixia Gao, Longqi Pan, Cuicui Shen, Chuanji Zhao, Feng Gao, Yi Zhang, Li Ren, Xiaoping Fang, Xiaoling Dun, Shengyi Liu, Lijiang Liu   +13 more
wiley   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

RNAse selection screen for RNAse V1.

, 2014
RNAse selection screen for RNAse V1.
Renata Ochocka (535928), Piotr Madanecki (560221), Susan Nozell (157202), James F. Collawn (551889), Rafal Bartoszewski (535921)   +4 more
core   +1 more source

Actividad Ribonucleasa en el Látex de Calotropis procera (Aiton) W.T. Aiton y Pedilanthus tithymaloides (L.) Poit / Ribonuclease Activity in Latex from Calotropis procera (Aiton) W.T. Aiton and Pedilanthus tithymaloides (L.) Poit

Revista Facultad Nacional de Agronomía Medellín, 2013
Las enzimas ribonucleasas (RNasas) han sido utilizadascon efectividad en el tratamiento de ciertos tipos de cáncer ypueden tener otras propiedades aplicables en biotecnología.
Emma Rueda de Arvelo, Catalina Ramis, Francisco Triana Alonso   +2 more
doaj  

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Aislamiento de péptidos inhibidores de bacterias a partir de bacterias ácido lácticas del tracto digestivo del lechón e identificación mediante prueba proteómica

Scientia Agropecuaria, 2017
En la alimentación porcina se usan antibióticos los cuales son un riesgo latente para la salud animal y pública. Los microorganismos son adquiridos del entorno durante las diferentes etapas de su vida, algunas bacterias que colonizan y logran ser parte ...
Héctor Sánchez, Gloria Ochoa, Carmen Rojas, Tessy Peralta, Alberto Ordinola   +4 more
doaj   +2 more sources

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Removal of the membrane anchor enables RNase Y to suppress the phenotypes of a ΔcshA mutant.

, 2015
(A) In the left panel, over-night cultures of single mutants ΔcshA, ΔY and YΔ2–24 and double mutants ΔYΔcshA and YΔ2–24ΔcshA were diluted, spotted on agar-plates, and incubated at the indicated temperatures and times.
Julien Prados (743297), Vanessa Khemici (814639), Patrick Linder (7345), Peter Redder (528225)   +3 more
core   +1 more source

T6SS4 is heterogeneously expressed in Yersinia pseudotuberculosis and is a target for transcriptional and post-transcriptional regulation.

PLoS Pathogens
The type VI secretion system (T6SS) is a complex secretion system encoded by many Gram-negative bacteria to translocate effector proteins directly into target cells.
Anna Kerwien, Britta Körner, Ines Meyer, Yannick Teschke, Cassandra Sophie Köster, Ileana Paula Salto, Petra Dersch, Anne-Sophie Herbrüggen   +7 more
doaj   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source