Results 81 to 90 of about 21,290,096 (239)

Role of Translesion Synthesis (TLS) polymerases in rNMPs incorporation during DNA replication

, 2014
Ribonuclease H (RNase H) are evolutionary conserved enzymes that cleave the RNA moiety in RNA:DNA hybrid molecules. It has been found that replicative DNA polymerases can incorporate rNTPs in place of dNTPs during DNA replication with an unexpected high ...
A. Meroni, P. Plevani, S. Sertic, F. Lazzaro, Sara Pizzi, M. Muzi Falconi, Thomas A. Kunkel, D. Delmastro, Peter M. J. Burger   +8 more
core   +2 more sources

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

The X-ray structure of the non-covalent dimeric form of S16G,A19P,Q28L,R31C,S32C mutant of RNase A re-opens the question of structure-cytotoxic activity relationship in dimeric RNases

, 2010
Pancreatic ribonucleases, thanks to their ability to degrade RNA, represent potential antitumor therapeutics. It has been suggested that RNases have to reach the cytosol and to avoid the binding of the ribonuclease inhibitor (RI) in order to exert ...
MAZZARELLA, LELIO, SICA, FILOMENA, MERLINO, ANTONELLO, PICONE, DELIA, RUSSO KRAUSS, IRENE, ERCOLE, CARMINE   +5 more
core  

Hfq Globally Binds and Destabilizes sRNAs and mRNAs in Yersinia pestis

mSystems, 2019
Hfq is a ubiquitous Sm-like RNA-binding protein in bacteria involved in physiological fitness and pathogenesis, while its in vivo binding nature remains elusive. Here we reported genome-wide Hfq-bound RNAs in Yersinia pestis, a causative agent of plague,
Yanping Han, Dong Chen, Yanfeng Yan, Xiaofang Gao, Zizhong Liu, Yaqiang Xue, Yi Zhang, Ruifu Yang   +7 more
doaj   +1 more source

A Pentaradial and Bilateral Combined Photoreception System in the Sea Cucumber is Mediated by a Blue Light‐Sensitive R‐Opsin

Advanced Science, EarlyView.
The sea cucumber Holothuria leucospilota detects blue and adjacent wavelengths of light via an r‐opsin with a maximum absorption at 459 nm. In the oral tentacles, papillae, and tube feet, distinct light‐sensing structures with specialized morphologies are formed, constituting a unique pentaradial and bilateral combined photoreception system.
Jiasheng Huang, Chunhua Ren, Zhou Qin, Yimeng Cui, Bingbing Zhang, Peng Luo, Xuan Wang, Yaoqi Xie, Xin Zhang, Aifen Yan, Yang Zhang, Dingding Fan, Yang Liu, Wenjie Pan, Xiao Jiang, Lihong Yuan, Haipeng Qin, David M. Irwin, Chaoqun Hu, Yang Liu, Ting Chen   +20 more
wiley   +1 more source

Cleavage of RatA, txpA, and the RatA/txpA hybrid by RNase III and RNase Y.

, 2012
(A) Cleavage of 5′ labeled txpA (0.5 pmol) alone or hybridized to a two-fold excess of unlabeled RatA by RNase III (3 ng) and RNase Y (2 µg) for the times indicated. A size standard is shown in lane M and an RNase T1 digestion of 5′ labeled txpA is shown
Ciarán Condon (10253), Sylvain Durand (67030), Laetitia Gilet (107095)   +2 more
core   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Degradation of the sigW-rsiW mRNA depends on RNase Y and RNase J1, while its transcription is dependent on RNase III.

, 2012
(A) Structure and predicted degradation pathway of the sigW-rsiW transcript. ORFs are shown as large white arrows, transcripts as thin black arrows. Scissors indicate cleavage by RNase Y, ‘Pacman’ symbols represent 5′-3′ degradation by RNase J1.
Pierre Nicolas (1549), Philippe Bessières (1550), Ciarán Condon (10253), Sylvain Durand (67030), Laetitia Gilet (107095)   +4 more
core   +1 more source

Hfq binding changes the structure of Escherichia coli small noncoding RNAs OxyS and RprA, which are involved in the riboregulation of rpoS [PDF]

, 2013
: OxyS and RprA are two small noncoding RNAs (sRNAs) that modulate the expression of rpoS, encoding an alternative sigma factor that activates transcription of multiple Escherichia coli stress-response genes.
Taylor, James E., Callaghan, Anastasia J., Helen A. Vincent, Phillips, Jack O., Cary, Peter, Vincent, H., Peter D. Cary, Sobott, F., Jack O. Phillips, Frank Sobott, Vincent, Helen A., Henderson, Charlotte A., Stone, Carlanne, Alessandra Casamento, Henderson, Charlotte, Carlanne M. Stone, Anastasia J. Callaghan, Darren M. Gowers, Cary, Peter D., Charlotte A. Henderson, James E.N. Taylor, Casamento, A., Callaghan, Anastasia, Phillips, Jack, Gowers, Darren, Casamento, Alessandra, Stone, Carlanne M., Sobott, Frank, Gowers, Darren M.   +28 more
core   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source