Results 71 to 80 of about 21,290,096 (239)

Nano Borophene as a Programmable 2D Scaffold for Organized DNA Assembly and Long‐Range Energy Transfer

Advanced Functional Materials, EarlyView.
Borophene is introduced as a programmable 2D bio‐interface that organizes DNA through dual boron–sulfur and nucleobase interactions. This molecular architecture enables efficient long‐range nanosurface energy transfer, establishing new design principles for functional nano–bio interfaces and amplification‐free optical biosensing.
Teresa Aditya, Pranay Saha, John M. Sansalone, Shraddha Krishnakumar, Matthew Molinaro, André J. van der Vlies, Nada Maher, Adrienne Griffiths, Zakhro Zakirova, Ketan Dighe, Narayana R. Aluru, Dipanjan Pan   +11 more
wiley   +1 more source

Deciphering the function of Com_YlbF domain-containing proteins in Staphylococcus aureus

Journal of Bacteriology
The Com_YlbF domain-containing proteins inhibit sporulation, competition, and biofilm formation by affecting the activity of ribonuclease RNase-Y in Bacillus subtilis.
Zayda-Lorena Corredor-Rozo, Ricaurte Marquez-Ortiz, Myriam L. Velandia-Romero, Deisy Abril, Johana Madroñero, Luisa F. Prada, Natasha Vanegas-Gomez, Begoña García, Maite Echeverz, María-Angelica Calderón-Peláez, Jacqueline Chaparro‑Olaya, Liliana Morales, Carlos Nieto‑Clavijo, Javier Escobar-Perez   +13 more
doaj   +1 more source

Dynamic Loading Regulates Meniscus‐Like Matrix Production in Human Mesenchymal Stromal Cell‐Seeded PET Scaffolds

Advanced Healthcare Materials, EarlyView.
Dynamic compression enhances mesenchymal stromal cell proliferation in nonwoven PET scaffolds under chondrogenic differentiation conditions and triggers mechanosensitive transcriptional programs associated with extracellular matrix remodeling. These findings highlight the potential of mechanically stimulated PET scaffolds as a promising platform for ...
Graciosa Quelhas Teixeira, Luisa de Roy, Anna‐Lotta Feldmeier, Mubashir Ahmad, Sofia Pilão, Maria Ahrens, Anita Ignatius, Carsten Linti, Andreas Martin Seitz   +8 more
wiley   +1 more source

Human immunodeficiency virus reverse transcriptase-associated RNase H activity [PDF]

, 1989
Biochemical characteristics of the RNase H activity associated with immunoaffinity purified human immunodeficiency virus (HIV) reverse transcriptase (RT) were examined.
STARNES, M., CHENG, Y
core   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Near‐Infrared Light‐Activated Polydopamine Nanoparticles Conjugated With Transferrin Peptides for Enhanced Brain Accumulation

Advanced Healthcare Materials, EarlyView.
This study demonstrates that Tf‐PDA NPs combine a receptor‐mediated targeting with mild photothermal activation to enhance nanoparticle accumulation in the brain. NIR‐activated Tf‐PDA NPs increase BBB permeability to NPs in vitro and in vivo without inducing cytotoxicity or adverse immune responses.
Rafaela Ferrão, Susana Simões, Paulo Rodrigues‐Santos, Vitor Francisco, Akhilesh Rai, Lino Ferreira   +5 more
wiley   +1 more source

Human RNase 7: a new cationic ribonuclease of the

, 2002
Here we report on the expression and function of RNase 7, one of the ®nal RNase A superfamily ribo-nucleases identi®ed in the human genome sequence. The human RNase 7 gene is expressed in various somatic tissues including the liver, kidney, skeletal ...
Helene F. Rosenberg, Rnase A Superfamily, Jianzhi Zhang, Kimberly D. Dyer   +3 more
core  

A functional RNase P protein subunit of bacterial origin in some eukaryotes [PDF]

, 2011
RNase P catalyzes 5′-maturation of tRNAs. While bacterial RNase P comprises an RNA catalyst and a protein cofactor, the eukaryotic (nuclear) variant contains an RNA and up to ten proteins, all unrelated to the bacterial protein.
Lai, Stella M., Mohannath, Gireesha, Venkat Gopalan, Pilar Bernal-Bayard, Gireesha Mohannath, Lai, Lien B., Bernal Bayard, Pilar, Vioque Peña, Agustín, Stella M. Lai, Gopalan, Venkat, Lien B. Lai, Agustín Vioque   +11 more
core   +1 more source

OTIMIZAÇÃO DA TÉCNICA DA PCR PARA A DETECÇÃO DO POLIMORFISMO CYP3A4*1B E FREQUÊNCIA ALÉLICA ENTRE 60 MORADORES DE SÃO LUÍS/MA

Cadernos de Pesquisa, 2013
Os objetivos deste trabalho foram adequar a técnica de PCR para o polimorfismo CYP3A4*1B, reduzir as amplificações inespecíficas observadas e verificar a frequência alélica do polimorfismo na população de São Luís/MA. A reação de PCR foi padronizada para
Bruna Aparecida Penha, Israel Higino de Sousa, Wandson Rodrigues Sousa, Jomar Diogo Nunes, Marcelo dos Santos, Sally Cristina Moutinho Monteiro   +5 more
doaj   +1 more source

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source