Results 41 to 50 of about 321,082 (269)
Viruses and the cellular RNA decay machinery. [PDF]
, 2010 The ability to control cellular and viral gene expression, either globally or selectively, is central to a successful viral infection, and it is also crucial for the host to respond and eradicate pathogens.
Gaglia, Marta, Glaunsinger, Britt
core +1 more source
PLoS Biology, 2014 DNA repair mechanisms are essential for preservation of genome integrity. However, it is not clear how DNA are selected and processed at broken ends by exonucleases during repair pathways.
Yu-Yuan Hsiao +4 more
doaj +1 more source
Inhibition of Murine Cytomegalovirus Infection in Animals by RNase P-Associated External Guide Sequences. [PDF]
, 2017 External guide sequence (EGS) RNAs are associated with ribonuclease P (RNase P), a tRNA processing enzyme, and represent promising agents for gene-targeting applications as they can direct RNase-P-mediated cleavage of a target mRNA.
Li, Wei +9 more
core +2 more sources
Bacillus subtilis Mutants with Knockouts of the Genes Encoding Ribonucleases RNase Y and RNase J1 Are Viable, with Major Defects in Cell Morphology, Sporulation, and Competence [PDF]
Journal of Bacteriology, 2013 ABSTRACT The genes encoding the ribonucleases RNase J1 and RNase Y have long been considered essential for Bacillus subtilis cell viability, even before there was concrete knowledge of their function as two of the most important enzymes for RNA turnover in this organism.
Figaro, Sabine +5 more
openaire +2 more sources
Frontiers in Microbiology, 2020 Viral diseases and their damage causing significant loss to economically important crops have increased by several folds during the last decade. All the conventional approaches are not able to eradicate the viral infection.
Antonina Sorokan +10 more
doaj +1 more source
Y-RNA and tRNA Cleavage by RNase L Mediates Terminal dsRNA Response [PDF]
, 2016 AbstractDouble-stranded RNA (dsRNA) is a danger signal that triggers endonucleolytic degradation of RNA inside infected and stressed mammalian cells. This mechanism inhibits growth and ultimately removes problematic cells via apoptosis. To elucidate the molecular functions of this program and understand the connection between RNA cleavage and ...
Donovan, Jesse +3 more
openaire +1 more source
A nitric oxide regulated small RNA controls expression of genes involved in redox homeostasis in Bacillus subtilis. [PDF]
PLoS Genetics, 2015 RsaE is the only known trans-acting small regulatory RNA (sRNA) besides the ubiquitous 6S RNA that is conserved between the human pathogen Staphylococcus aureus and the soil-dwelling Firmicute Bacillus subtilis.
Sylvain Durand +9 more
doaj +1 more source
RNase HI Is Essential for Survival of Mycobacterium smegmatis [PDF]
, 2015 RNases H are involved in the removal of RNA from RNA/DNA hybrids. Type I RNases H are thought to recognize and cleave the RNA/DNA duplex when at least four ribonucleotides are present.
Brzostek, Anna M. +7 more
core +5 more sources
RNA processing in Bacillus subtilis: identification of targets of the essential RNase Y
Molecular Microbiology, 2011 SummaryRNA processing and degradation is initiated by endonucleolytic cleavage of the target RNAs. In many bacteria, this activity is performed by RNase E which is not present in Bacillus subtilis and other Gram‐positive bacteria. Recently, the essential endoribonuclease RNase Y has been discovered in B. subtilis.
Lehnik-Habrink, Martin +5 more
openaire +3 more sources
PLoS Genetics, 2014 RNA decay and maturation have in recent years been recognised as major regulatory mechanisms in bacteria. In contrast to Escherichia coli, the Firmicute (Gram-positive) bacteria often do not encode the well-studied endonuclease RNase E, but instead rely ...
Patrick Linder +2 more
doaj +1 more source