Results 41 to 50 of about 21,290,096 (239)
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Decrease in gyrase A protein expression in _E. coli_ cells inhibited by antisense ribozymes [PDF]
, 2008 RNase P complexed with external guide sequence (EGS) represents a novel nucleic-acid-based gene interference approach to modulate gene expression. Nucleic acid-based gene interference technologies represent promising strategies for specific inhibition of
Malathi Raghunathan +1 more
core
RNA Degradation in Staphylococcus aureus: Diversity of Ribonucleases and Their Impact
International Journal of Genomics, 2015 The regulation of RNA decay is now widely recognized as having a central role in bacterial adaption to environmental stress. Here we present an overview on the diversity of ribonucleases (RNases) and their impact at the posttranscriptional level in the ...
Rémy A. Bonnin, Philippe Bouloc
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Clustering of IRE1α depends on sensing ER stress but not on its RNase activity
, 2019 The sensors of the unfolded protein response react to endoplasmic reticulum (ER) stress by transient activation of their enzymatic activities, which initiate various signaling cascades.
Chomistek S. +11 more
core +1 more source
Identification of new genes contributing to the extreme radioresistance of Deinococcus radiodurans using a Tn5-based transposon mutant library. [PDF]
PLoS ONE, 2015 Here, we have developed an extremely efficient in vivo Tn5-based mutagenesis procedure to construct a Deinococcus radiodurans insertion mutant library subsequently screened for sensitivity to genotoxic agents such as γ and UV radiations or mitomycin C ...
Rémi Dulermo +8 more
doaj +1 more source
PLoS Biology, 2023 Bacteria commonly adhere to surfaces where they compete for both space and resources. Despite the importance of surface growth, it remains largely elusive how bacteria evolve on surfaces.
Jordi van Gestel +2 more
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Caractérisation de la RNase E et du dégradosome d'ARN de la bactérie marine adaptée au froid Pseudoalteromonas haloplanktis [PDF]
, 2010 La dégradation des ARNm est l'un des processus biologiques essentiels qui implique chez les bactéries, l'intervention d'un complexe multiprotéique appelé « dégradosome d'ARN ».
Ait-Bara, Soraya
core
The ensemble diversity of non-coding RNA structure is lower than random sequence
Non-coding RNA Research, 2018 In addition to energetically optimal structures, RNAs can fold into near energy suboptimal conformations that may be populated and play functional roles.
Walter N. Moss
doaj +1 more source