Results 51 to 60 of about 118,581 (310)

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition. [PDF]

, 2017
Acquired drug resistance prevents cancer therapies from achieving stable and complete responses. Emerging evidence implicates a key role for non-mutational drug resistance mechanisms underlying the survival of residual cancer 'persister' cells.
Berens, Michael E, Bole, Dhruv, Dhruv, Harshil D, Eaton, John K, Galeas, Jacqueline, Hangauer, Matthew J, Matov, Alexandre, McCormick, Frank, McManus, Michael T, Ryan, Matthew J, Schreiber, Stuart L, Viswanathan, Vasanthi S   +11 more
core   +1 more source

A high coverage reference transcriptome assembly of pea (Pisum sativum L.) mycorrhizal roots

Вавиловский журнал генетики и селекции, 2020
Arbuscular mycorrhiza (AM) is an ancient mutualistic symbiosis formed by 80–90 % of land plant species with the obligatorily biotrophic fungi that belong to the phylum Glomeromycota.
A. M. Afonin, I. V. Leppyanen, O. A. Kulaeva, O. Y. Shtark, I. A. Tikhonovich, E. A. Dolgikh, V. A. Zhukov   +6 more
doaj   +1 more source

Upregulation of the microRNA cluster at the Dlk1-Dio3 locus in lung adenocarcinoma. [PDF]

, 2015
Mice in which lung epithelial cells can be induced to express an oncogenic Kras(G12D) develop lung adenocarcinomas in a manner analogous to humans. A myriad of genetic changes accompany lung adenocarcinomas, many of which are poorly understood.
Caswell, DR, Chu, K, Chuang, C-H, Kay, MA, Kim, HK, Roy-Chaudhuri, B, Sayles, LC, Sweet-Cordero, EA, Valdmanis, PN, Winslow, MM, Zhang, Y, Zheng, Y   +11 more
core   +2 more sources

Comparison of visualization tools for single-cell RNAseq data [PDF]

NAR Genomics and Bioinformatics, 2020
Abstract In the last decade, single cell RNAseq (scRNAseq) datasets have grown in size from a single cell to millions of cells. Due to its high dimensionality, it is not always feasible to visualize scRNAseq data and share it in a scientific report or an article publication format. Recently, many interactive analysis and visualization
Batuhan Cakir, Martin Prete, Ni Huang, Stijn van Dongen, Pinar Pir, Vladimir Yu Kiselev   +5 more
openaire   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Achievements and prospects of applying high-throughput sequencing techniques to potato genetics and breeding

Вавиловский журнал генетики и селекции, 2017
In recent years, marker-assisted selection (MAS) has been intensively used to increase potato breeding efficiency. Large-scale studies of the potato genome and genes exploiting next-generation sequence (NGS) approaches are required for broad application ...
I. V. Bykova, N. A. Shmakov, D. A. Afonnikov, A. V. Kochetov, E. K. Khlestkina   +4 more
doaj   +1 more source

Changing Technologies of RNA Sequencing and Their Applications in Clinical Oncology

Frontiers in Oncology, 2020
RNA sequencing (RNAseq) is one of the most commonly used techniques in life sciences, and has been widely used in cancer research, drug development, and cancer diagnosis and prognosis.
Ye Wang, Michael Mashock, Zhuang Tong, Xiaofeng Mu, Xiaofeng Mu, Hong Chen, Xin Zhou, Hong Zhang, Gexin Zhao, Bin Liu, Xinmin Li   +10 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

MSI expresso: a software for determining MSI status and detecting MSI-related transcription events from RNA sequencing data

Frontiers in Genetics
Summary: Microsatellite instability (MSI) is becoming increasingly important in oncology as it has been reported across more than two dozen of solid cancer types.
Emmanuel Tubacher, Alexandre How-Kit, Mourad Sahbatou, Alex Duval, Victor Renault, Jean-François Deleuze, Jean-François Deleuze   +6 more
doaj   +1 more source

In silico Analysis of Publicly Available Transcriptomics Data Identifies Putative Prognostic and Therapeutic Molecular Targets for Papillary Thyroid Carcinoma

International Journal of General Medicine, 2022
Asma Almansoori,1,* Poorna Manasa Bhamidimarri,1,* Riyad Bendardaf,2,3 Rifat Hamoudi1,2,4 1Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates; 2College of Medicine, University of Sharjah, Sharjah, United ...
Almansoori A, Bhamidimarri PM, Bendardaf R, Hamoudi R   +3 more
doaj