Results 41 to 50 of about 118,581 (310)

An Inversion Disrupting FAM134B Is Associated with Sensory Neuropathy in the Border Collie Dog Breed [PDF]

, 2016
Sensory neuropathy in the Border Collie is a severe neurological disorder caused by the degeneration of sensory and, to a lesser extent, motor nerve cells with clinical signs starting between 2 and 7 months of age.
Beltran, E, De Risio, L, Forman, O P, Gutierrez-Quintana, R, Hitti, R J, Jenkins, C A, Mellersh, C, O'Brien, D P, Pettitt, L, Shelton, G D   +9 more
core   +4 more sources

ngn-1/neurogenin Activates Transcription of Multiple Terminal Selector Transcription Factors in the Caenorhabditis elegans Nervous System

G3: Genes, Genomes, Genetics, 2020
Proper nervous system development is required for an organism’s survival and function. Defects in neurogenesis have been linked to neurodevelopmental disorders such as schizophrenia and autism.
Elyse L. Christensen, Alexandra Beasley, Jessica Radchuk, Zachery E. Mielko, Elicia Preston, Sidney Stuckett, John I. Murray, Martin L. Hudson   +7 more
doaj   +1 more source

Targeted RNA-seq improves efficiency, resolution, and accuracy of allele specific expression for human term placentas

G3: Genes, Genomes, Genetics, 2021
Genomic imprinting is an epigenetic mechanism that results in allele-specific expression (ASE) based on the parent of origin. It is known to play a role in the prenatal and postnatal allocation of maternal resources in mammals.
Weisheng Wu, Jennie L Lovett, Kerby Shedden, Beverly I Strassmann, Claudius Vincenz   +4 more
doaj   +1 more source

Characterization of gene cluster heterogeneity in single-cell transcriptomic data within and across cancer types

Biology Open, 2022
Despite the remarkable progress in probing tumor transcriptomic heterogeneity by single-cell RNA sequencing (sc-RNAseq) data, several gaps exist in prior studies. Tumor heterogeneity is frequently mentioned but not quantified.
Khong-Loon Tiong, Yu-Wei Lin, Chen-Hsiang Yeang   +2 more
doaj   +1 more source

Extracellular vesicles produced in B cells deliver tumor suppressor miR-335 to breast cancer cells disrupting oncogenic programming in vitro and in vivo. [PDF]

, 2018
The successful implementation of miRNA (miR) therapies in humans will ultimately rely on the use of vehicles with improved cellular delivery capability. Here we tested a new system that leverages extracellular vesicles (EVs) laden with a tumor suppressor
Almanza, Gonzalo, Carter, Hannah, Jepsen, Kristen, Rodvold, Jeffrey J, Tsui, Brian, Zanetti, Maurizio   +5 more
core   +2 more sources

Combinatorial Discriminant Analysis Applied to RNAseq Data Reveals a Set of 10 Transcripts as Signatures of Exposure of Cattle to Mycobacterium avium subsp. paratuberculosis

Animals, 2020
Paratuberculosis or Johne’s disease in cattle is a chronic granulomatous gastroenteritis caused by infection with Mycobacterium avium subspecies paratuberculosis (MAP).
Michela Malvisi, Nico Curti, Daniel Remondini, Maria Grazia De Iorio, Fiorentina Palazzo, Gustavo Gandini, Silvia Vitali, Michele Polli, John L. Williams, Giulietta Minozzi   +9 more
doaj   +1 more source

The expanding toolkit of translating ribosome affinity purification [PDF]

, 2017
Translating ribosome affinity purification is a method initially developed for profiling mRNA from genetically defined cell types in complex tissues. It has been applied both to identify target molecules in cell types that are important for controlling a
Dougherty, Joseph D
core   +2 more sources

Large scale comparison of gene expression levels by microarrays and RNAseq using TCGA data. [PDF]

PLoS ONE, 2013
RNAseq and microarray methods are frequently used to measure gene expression level. While similar in purpose, there are fundamental differences between the two technologies.
Yan Guo, Quanhu Sheng, Jiang Li, Fei Ye, David C Samuels, Yu Shyr   +5 more
doaj   +1 more source

Transcriptome-Powered Pluripotent Stem Cell Differentiation for Regenerative Medicine

Cells, 2023
Pluripotent stem cells are endless sources for in vitro engineering human tissues for regenerative medicine. Extensive studies have demonstrated that transcription factors are the key to stem cell lineage commitment and differentiation efficacy.
Derek A. Ogi, Sha Jin
doaj   +1 more source

Interferon lambda protects the female reproductive tract against Zika virus infection [PDF]

, 2019
Zika virus infections can cause devastating congenital birth defects but the underlying interactions with the host immune system are not well understood.
Arora, Nitin, Artyomov, Maxim N., Caine, Elizabeth A., Coyne, Carolyn B., Diamond, Michael S., Moley, Kelle H., Scheaffer, Suzanne M., Zaitsev, Konstantin   +7 more
core   +3 more sources