Results 51 to 60 of about 24,468 (303)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Proactive safety assessment of urban through-roads based on GPS data
Archives of TransportRoad safety is a worldwide issue, while urban roads account for a high share of serious road injuries, especially involving vulnerable road users, such as pedestrians or cyclists.
Jiri Ambros +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Centrifuge Model Test on Stratum Deformation Rule of Loess Road Tunnel Based on Double-hole Effect
工程科学与技术, 2013 :In order to understand the stratum deformation rule of loess road tunnel under the influence of double-hole effect more comprehensively,four groups of model tests were carried out systematically with the centrifuge model test device, based on the ...
来弘鹏, 杨万精, 谢永利
doaj
Traffic Calming Measures: An Evaluation of the Effect on Driving Speed
Promet (Zagreb), 2017 Road accidents are one of the leading causes of death in the world, particularly among young people. Excessive speed is one of the main risk factors in road traffic safety, increasing accident probability and affecting accident severity.
Audrius Vaitkus +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Effect of Sensor Spacing on Performance Measure Calculations
, 2006 State and local departments of transportation (DOTs) increasingly deploy road detectors, such as inductive loops, to monitor congestion on their road networks.
Rich Margiotta +3 more
core +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source