Results 41 to 50 of about 123,780 (265)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

A diffusion model-based image generation framework for underwater object detection

open access: yesCommunications Engineering
Underwater object detection plays a crucial role in applications such as marine ecological monitoring and underwater rescue operations. However, challenges such as limited underwater data availability and low scene diversity hinder detection accuracy. In
Yaoming Zhuang   +8 more
doaj   +1 more source

Topological Map Construction Based on Region Dynamic Growing and Map Representation Method

open access: yesApplied Sciences, 2019
In the human⁻machine interactive scene of the service robot, obstacle information and destination information are both required, and both kinds of information need to be saved and used at the same time.
Fei Wang   +4 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Extending Driving Vision Based on Image Mosaic Technique

open access: yesMATEC Web of Conferences, 2017
Car cameras have been used extensively to assist driving by make driving visible. However, due to the limitation of the Angle of View (AoV), the dead zone still exists, which is a primary origin of car accidents.
Chen Deng   +9 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Collision Avoidance of Multi-UUV Systems Based on Deep Reinforcement Learning in Complex Marine Environments

open access: yesJournal of Marine Science and Engineering
For multiple unmanned underwater vehicles (UUVs) systems, obstacle avoidance during cooperative operation in complex marine environments remains a challenging issue.
Fuyu Cao   +5 more
doaj   +1 more source

Robotic Endoscopy [PDF]

open access: yesVisceral Medicine, 2018
Endoscopes extend the eyes of the physician into the patient's body. They are widely used in gastrointestinal (GI) diagnostics and minimally invasive surgery. Endoscopes can be classified into 3 types: rigid, flexible, and capsule endoscopes. Rigid and flexible endoscopes are traditionally held and manipulated by the physician to visualize the region ...
Zheng, Li, Philip Wai-Yan, Chiu
openaire   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Development of user-customized online teaching technology based on GPT, enhanced by generative AI-based motion recognition

open access: yesScientific Reports
This paper addresses current issues in existing joint tracking and motion recognition algorithms for Human Pose Estimation. It proposes a solution using the Numerical Discriminator Generative Adversarial Network (ND_GAN) to improve the performance of ...
Kyoung-Geun Cho   +9 more
doaj   +1 more source

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