Results 41 to 50 of about 1,519,887 (304)

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Ultra-lightweight robotic hip exoskeleton with anti-phase torque symmetry for enhanced walking efficiency

Scientific Reports
This paper presents a novel robotic exoskeleton that is exceptionally lightweight and compact, while providing effective gait assistance. To maximize the system’s assistance-to-weight/size ratio, the design focuses on two key aspects of human gait ...
Bokman Lim, Byungjune Choi, Changhyun Roh, Jewoo Lee, Yong-Jae Kim, Younbaek Lee   +5 more
doaj   +1 more source

Pattern Classification Using Quantized Neural Networks for FPGA-Based Low-Power IoT Devices

Sensors, 2022
With the recent growth of the Internet of Things (IoT) and the demand for faster computation, quantized neural networks (QNNs) or QNN-enabled IoT can offer better performance than conventional convolution neural networks (CNNs).
Manas Ranjan Biswal, Tahesin Samira Delwar, Abrar Siddique, Prangyadarsini Behera, Yeji Choi, Jee-Youl Ryu   +5 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Exploration of Mehrabian’s communication model with an android

Scientific Reports
Multimodal emotional expressions play an essential role in real-life communication. Mehrabian and colleagues suggested that facial expressions may have the greatest emotional impact, followed by vocal and verbal expressions.
Wataru Sato, Koh Shimokawa, Takashi Minato   +2 more
doaj   +1 more source

Contact Model of Revolute Joint with Clearance Based on Fractal Theory

Chinese Journal of Mechanical Engineering, 2018
The contact stiffness of a mechanical bonding surface is an important parameter in determining the normal and radial contact force. To improve the calculation accuracy of the contact force model, the surface roughness of the bonding surface and the ...
Shi-Hua Li, Xue-Yan Han, Jun-Qi Wang, Jing Sun, Fu-Juan Li   +4 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

The ACCEPTance of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis

Molecular Oncology, EarlyView.
This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo, Marco Siringo, Alessandro Vici, Ann Zeuner, Orietta Gandini, Paola Gazzaniga, Chiara Nicolazzo   +6 more
wiley   +1 more source

Extending Driving Vision Based on Image Mosaic Technique

MATEC Web of Conferences, 2017
Car cameras have been used extensively to assist driving by make driving visible. However, due to the limitation of the Angle of View (AoV), the dead zone still exists, which is a primary origin of car accidents.
Chen Deng, Zhang Yanduo, Wei Wei, Li Xiaolin, Zhou Huabing, Zhu Rui, Lu Tao, Li Xun, Xu Haijiao, Peng Li   +9 more
doaj   +1 more source

Type Synthesis of Fully Decoupled Three Translational Parallel Mechanism with Closed-Loop Units and High Stiffness

Chinese Journal of Mechanical Engineering, 2023
In order to solve the problem of weak stiffness of the existing fully decoupled parallel mechanism, a new synthesis method of fully decoupled three translational (3T) parallel mechanisms (PMs) with closed-loop units and high stiffness is proposed based ...
Shihua Li, Sen Wang, Haoran Li, Yongjie Wang, Shuang Chen   +4 more
doaj   +1 more source