Results 31 to 40 of about 5,087 (257)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Performance and Effectiveness of the Passive-Compliant Citrus-Picking Manipulator

Applied Sciences
The application of citrus-picking robotic hands in orchard environments is constrained by the diversity in fruit size and shape, as well as the need to control fruit damage during harvesting.
Daode Zhang, Haibing Yang, Zhiyong Yang, Wei Zhang   +3 more
doaj   +1 more source

Design and Prototyping of an Interchangeable and Underactuated Tool for Automatic Harvesting

Robotics, 2022
In the field of precision agriculture, the automation of sampling and harvesting operations plays a central role to expand the possible application scenarios.
Giuseppe Quaglia, Luigi Tagliavini, Giovanni Colucci, Ardit Vorfi, Andrea Botta, Lorenzo Baglieri   +5 more
doaj   +1 more source

Robotic Complex for Harvesting Apple Crops

Robotics, 2022
The article deals with the concept of building an automated system for the harvesting of apple crops. This system is a robotic complex mounted on a tractor cart, including an industrial robot and a packaging system with a container for fruit collection. The robot is equipped with a vacuum gripper and a vision system.
Oleg Krakhmalev, Sergey Gataullin, Eldar Boltachev, Sergey Korchagin, Ivan Blagoveshchensky, Kang Liang   +5 more
openaire   +2 more sources

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Development of a General-Purpose AI-Powered Robotic Platform for Strawberry Harvesting

Agriculture
The integration of emerging technologies such as robotics and artificial intelligence (AI) has the potential to transform agricultural harvesting by improving efficiency, reducing waste, lowering labor dependency, and enhancing produce quality.
Muhammad Tufail, Jamshed Iqbal, Rafiq Ahmad   +2 more
doaj   +1 more source

Agricultural Autonomous Robotic Platform Motion Control

Сельскохозяйственные машины и технологии, 2023
A model of the movement of a robotic platform adapted to the conditions of an industrial orchard is proposed. (Research purpose) Development of a motion control system for an autonomous robotic wheeled platform based on inertial and satellite navigation ...
D. O. Khort, A. I. Kutyrev, I. G. Smirnov, G. V. Moiseev, V. I. Soloviev   +4 more
doaj   +1 more source