Results 61 to 70 of about 1,596,868 (270)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Venture Capital and Private Equity Diversification: A Var and DCC Garch Approach

Корпоративные финансы
The terms “venture capital” and “private equity” are used in a loosely interchangeable manner when capital is invested in innovative technology-driven ideas or nascent-stage/unlisted companies.
Manu Sharma
doaj   +1 more source

Velocity Estimation for Space Infrared Dim Targets Based on Multi-Satellite Observation and Robust Locally Weighted Regression

Remote Sensing, 2023
Velocity estimation of space moving targets is a key part of space situational awareness. However, most of the existing methods do not consider the satellite observation process, and the performance mainly depends on the preset target motion state, which
Shenghao Zhang, Peng Rao, Hao Zhang, Xin Chen   +3 more
doaj   +1 more source

Robust Linear Regression Analysis - A Greedy Approach

, 2015
The task of robust linear estimation in the presence of outliers is of particular importance in signal processing, statistics and machine learning. Although the problem has been stated a few decades ago and solved using classical (considered nowadays ...
Bouboulis, Pantelis, Papageorgiou, George, Themelis, Kostantinos, Theodoridis, Sergios   +3 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Robust bayesian inference in empirical regression models [PDF]

, 1991
Broadening the stochastic assumptions on the error terms of regression models was prompted by the analysis of linear multivariate t models in Zellner (1976).
Osiewalski, Jacek, Steel, Mark F.J.
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Contrasting Ecological Effects of Farmland and Alfalfa Grassland Across Different Planting Scales in the North China Plain

Agronomy
Purpose: Comparing farmland and alfalfa grassland systems under different planting scales in influencing grain yield and environmental security is crucial to achieving sustainable food development. This study aims to evaluate the environmental impacts of
Xiaoyu Zhu, Yutong Li, Zhongkuan Liu, Changliang Shao, Lulu Wang, Xiaoping Xin   +5 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Bridging Prosperity: Unravelling the Interplay of Public Borrowing, Gross Capital Formation, and Economic Growth In The Nepalese Economy

Financial Internet Quarterly
This study investigates the impact of public borrowing and total capital formation on Nepal’s economic growth. The analysis relies on secondary data from publications from the Nepal Rastra Bank and economic surveys conducted in Nepal.
Dahal Arjun Kumar, Bhattarai Ganesh, Budhathoki Prem Bahadur, Adhikari Gyan Mani   +3 more
doaj   +1 more source